[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

Jadvar, Hossein; Quan, Vicki; Henderson, Robert W.; Conti, Peter S.

doi:10.1007/s10147-007-0720-8

Cited by 66 publications

(30 citation statements)

References 15 publications

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“…For bladder cancer, [18F]fluorodeoxyglucose (FDG) -PET/CT predicts survival of MIBC patients by detecting occult metastases in clinically localised by detecting occult metastases in clinically localised MIBC 12) . However, measuring the standard uptake value of MIBC at a primary site is difficult due to the intense accumulation of excreted FDG in urine 13,14) . In this respect, DWI -MRI offers more advantages as a means of obtaining quantitative information on primary sites of bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Apparent diffusion coefficient on magnetic resonance imaging (MRI) in bladder cancer: relations with recurrence/progression risk

Kikuchi

Shigihara

Hashimoto

et al. 2017

FJMS

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AIMS :To evaluate the relationship between the apparent diffusion coefficient (ADC) value for bladder cancer and the recurrence/progression risk of post -transurethral resection (TUR). METHODS : Forty -one patients with initial and non -muscle -invasive bladder cancer underwent MRI from 2009 to 2012. Two radiologists measured ADC values. A pathologist calculated the recurrence/progression scores, and risk was classified based on the scores. Pearson's correlation was used to analyze the correlations of ADC value with each score and with each risk group, and the optimal cut -off value was established based on receiver operating characteristic (ROC) curve analysis. Furthermore, the relationship between actual recurrence / progression of cases and ADC values was examined by Unpaird U test. RESULTS : There were significant correlations between ADC value and the recurrence score as well as the progression score (P<0.01, P<0.01, respectively). There were also significant correlations between ADC value and the recurrence risk group as well as progression risk group (P=0.042, P<0.01, respectively). The ADC cut -off value on ROC analysis was 1.365 (sensitivity 100% ; specificity 97.4%) for the low and intermediate recurrence risk groups, 1.024 (sensitivity 47.4% ; specificity 100%) for the intermediate and high recurrence risk groups, 1.252 (sensitivity 83.3% ; specificity 81.3%) for the low and intermediate progression risk groups, and 0.955 (sensitivity 87.5% ; specificity 63.2%) between the intermediate and high progression risk groups. The difference between the ADC values of the recurrence and nonrecurrence group in Unpaired t test was significant (P<0.05). CONCLUSION : ADC on MRI in bladder cancer could potentially be useful, non -invasive measurement for estimating the risks of recurrence and progression.

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Section: Discussionmentioning

confidence: 99%

Apparent diffusion coefficient on magnetic resonance imaging (MRI) in bladder cancer: relations with recurrence/progression risk

Kikuchi

Shigihara

Hashimoto

et al. 2017

FJMS

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“…Several studies described increased accuracy and high specificity rates especially in the detection of lymph nodes or distant metastases to bone and visceral organs with 18 F-FDG-based [13,16,17,19,20], 11 C-choline-based [14,24,37] or 11 C-acetate-based [24] PET/CT, which had an impact on further clinical management in a significant number of patients. Therefore, those authors concluded that PET/CT might have the ability to replace standard cross-sectional imaging or bone scintigraphy in the staging of BCa.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last few years PET/CT with the tracers 18 F-FDG, 11 C-choline or 11 C-acetate has evolved as a new staging modality combining cross-sectional anatomical and functional imaging [13,14,15,16,17,18,19,20,21,22,23,24,25,26]. Several studies described increased accuracy and high specificity rates especially in the detection of lymph nodes or distant metastases to bone and visceral organs with 18 F-FDG-based [13,16,17,19,20], 11 C-choline-based [14,24,37] or 11 C-acetate-based [24] PET/CT, which had an impact on further clinical management in a significant number of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, positron emission tomography (PET) as functional imaging with tracers like 18 F-FDG, 11 C-choline or 11 C-acetate in combination with CT has been introduced [13,14,15,16,17,18,19,20,21,22,23,24,25,26]. However, these studies present conflicting data as to whether these new imaging modalities are able to improve clinical staging in comparison to results of the ‘gold standard' histopathology.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of <sup>11</sup>C-Choline PET/CT and CT for Predicting Survival of Bladder Cancer Patients Treated with Radical Cystectomy

Maurer

Horn²,

Souvatzoglou³

et al. 2014

Urol Int

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Background: In patients with bladder cancer (BCa) preoperative staging with ¹¹C-choline positron emission tomography-computed tomography (PET/CT) could be used to derive prognostic information and hence stratify patients preoperatively with respect to disease management. Methods: From June 2004 to May 2007, 44 patients with localized BCa were staged with ¹¹C-choline PET/CT before radical cystectomy. The results of imaging were correlated to overall survival (OS) and cumulative incidence of cancer-specific death (CSD). Results: There was no statistically significant difference in OS and CSD between the patient groups when stratified for organ-confined versus non-organ-confined disease or lymph node involvement defined by either ¹¹C-choline PET/CT (OS: p = 0.262, hazard ratio [HR] = 1.60; p = 0.527, HR = 0.76; CSD: p = 0.144, HR = 2.25; p = 0.976, HR = 0.98) or CT (OS: p = 0.518, HR = 1.34; p = 0.228, HR = 1.67; CSD: p = 0.323, HR = 1.90; p = 0.136, HR = 2.38). The limitation of this study is the small number of included patients. Conclusion: In our prospective trial neither CT nor ¹¹C-choline PET/CT were able to sufficiently predict OS or CSD in BCa patients treated with radical cystectomy albeit trends and moderately increased HRs could be demonstrated without significant differences between CT or ¹¹C-choline PET/CT. However, these trends might prove statistically significant in bigger patient cohorts. Therefore initial transsectional imaging might be of clinical relevance in respect to prognosis and could play a role in the counseling of BCa patients.

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“…However, the main obstacle in the evaluation of bladder cancer is that the urinary excretion of 18 F-FDG interferes with the visualization of primary tumors and regional lymph nodes (Fig. 6) (27). In order to help overcome this limitation, Kamel et al employed a method of diuretics and parenteral physiologic saline infusion in order to better evaluate abdominopelvic malignancies (28).…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Imaging of bladder cancer: update on current approaches for diagnosis

Türkbey

Ravizzini

et al. 2011

Journal of the Belgian Society of Radiology

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[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma

Cited by 66 publications

References 15 publications

Apparent diffusion coefficient on magnetic resonance imaging (MRI) in bladder cancer: relations with recurrence/progression risk

Apparent diffusion coefficient on magnetic resonance imaging (MRI) in bladder cancer: relations with recurrence/progression risk

Prognostic Value of <sup>11</sup>C-Choline PET/CT and CT for Predicting Survival of Bladder Cancer Patients Treated with Radical Cystectomy

Imaging of bladder cancer: update on current approaches for diagnosis

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