Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density

Fujimura, Sadao; Ueda, Kohei; Nomura, Yoko; Yanagi, Yasuo

doi:10.2147/opth.s119251

Cited by 18 publications

(15 citation statements)

References 33 publications

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“…However, the results from this study show stronger correlations between serum carotenoid concentrations and MPOV than previously reported using subjective methods (nonimaging-based systems) and for imaging techniques reporting only at a single eccentricity 41. The current finding is consistent with other studies,42 as confirmed by Conrady et al,33 also using the Spectralis MPOD module, where serum carotenoid concentrations showed a stronger correlation when a broader area of MP was assessed and reported. As expected, in our study MPOV exhibited a strong correlation with MPOD at all eccentricities; however, the strength of the agreement increased with increasing eccentricity.…”

Section: Discussionsupporting

confidence: 90%

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Green

Bernstein

Curcio

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose: It is essential to have an appropriate measure to assess macular pigment (MP) that can provide an accurate, valid, and reliable representation of the MP within the macula. The aim of this study was to describe and introduce MP optical volume (MPOV) as an optimal value for reporting MP. Methods: Three hundred ninety-three subjects were analyzed using the Heidelberg Spectralis with the investigational MP optical density (MPOD) module to measure MPOV and MPOD at four foveal eccentricities (0.238, 0.518, 0.988, 1.768 [78 as reference point]). Lutein (L) and zeaxanthin (Z) dietary intake and serum concentrations were evaluated. Results: MPOV mean was 5094 (95%CI, 4877-5310); range: 527 to 10,652. MPOV was inversely correlated with body mass index and positively correlated with education (r ¼ À0.156, P ¼ 0.002 and r ¼ 0.124, P ¼ 0.014, respectively). Serum concentrations of L and Z were positively correlated with MPOV (r ¼ 0.422, P , 0.001 and r ¼ 0.285, P , 0.001, respectively). MPOV was positively correlated to MPOD at all measured eccentricities, with the strongest agreement at 1.768 (r ¼ 0.906, P , 0.001). Serum concentrations of L and Z, BMI, education, and age (P , 0.001) were found to be significant predictors of MPOV. Conclusions: The Spectralis MPOV measurement provided a comprehensive and detailed evaluation of the MP profile. The Spectralis MPOV should be considered a preferred metric for the assessment of MP.

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Section: Discussionsupporting

confidence: 90%

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Green

Bernstein

Curcio

et al. 2019

Trans. Vis. Sci. Tech.

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“…Since lutein must be obtained from the diet, principally from leafy green vegetables, fruits, and egg yolk [19], researchers have explored whether dietary supplementation with lutein might prevent AMD in healthy people or improve the condition of patients with AMD. Several studies support these possibilities [15, 20, 21] and have demonstrated that lutein supplementation can improve visual acuity [22]. On the other hand, one study showed that supplementation did not significantly improve MPOD in patients with early AMD [23].…”

Section: Introductionmentioning

confidence: 99%

Effects of lutein supplementation in age-related macular degeneration

et al. 2019

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The purpose of this meta-analysis was to evaluate the effects of lutein supplementation on macular pigment optical density (MPOD) in randomized controlled trials involving patients with age-related macular degeneration (AMD). A comprehensive search of the literature was performed in PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wan Fang database through December 2018. Nine randomized controlled trials involving 920 eyes (855 with AMD) were included. Meta-analysis suggested that lutein supplementation (10 or 20 mg per day) was associated with an increase in MPOD (mean difference (MD) 0.07; 95% confidence interval (CI) 0.03 to 0.10), visual acuity (MD 0.28; 95%CI 0.06 to 0.50) and contrast sensitivity (MD 0.26; 95%CI 0.22 to 0.30). Stratified analyses showed the increase in MPOD to be faster and greater with higher dose and longer treatment. The available evidence suggests that dietary lutein may be beneficial to AMD patients and the higher dose could make MPOD increase in a shorter time.

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“… 12 Skin Raman requires specialized equipment and cannot readily distinguish between the various carotenoids, but it is rapid, painless, and correlates well with HPLC total serum and biopsied tissue concentrations, and moderately well with dietary surveys. 13 , 14 Unfortunately, serum and skin carotenoid measurements have not correlated particularly well with assessments of ocular carotenoid status ( Tables 1 , 2 ), 15 – 28 and dietary correlations have fared even worse. In the published literature, although these correlations with macular pigment may be statistically significant, the r values are typically very low.…”

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confidence: 99%

Correlations Between Macular, Skin, and Serum Carotenoids

Conrady

Bell

Besch

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeOcular and systemic measurement and imaging of the macular carotenoids lutein and zeaxanthin have been employed extensively as potential biomarkers of AMD risk. In this study, we systematically compare dual wavelength retinal autofluorescence imaging (AFI) of macular pigment with skin resonance Raman spectroscopy (RRS) and serum carotenoid levels in a clinic-based population.MethodsEighty-eight patients were recruited from retina and general ophthalmology practices from a tertiary referral center and excluded only if they did not have all three modalities tested, had a diagnosis of macular telangiectasia (MacTel) or Stargardt disease, or had poor AFI image quality. Skin, macular, and serum carotenoid levels were measured by RRS, AFI, and HPLC, respectively.ResultsSkin RRS measurements and serum zeaxanthin concentrations correlated most strongly with AFI macular pigment volume under the curve (MPVUC) measurements up to 9° eccentricity relative to MPVUC or rotationally averaged macular pigment optical density (MPOD) measurements at smaller eccentricities. These measurements were reproducible and not significantly affected by cataracts. We also found that these techniques could readily identify subjects taking oral carotenoid-containing supplements.ConclusionsLarger macular pigment volume AFI and skin RRS measurements are noninvasive, objective, and reliable methods to assess ocular and systemic carotenoid levels. They are an attractive alternative to psychophysical and optical methods that measure MPOD at a limited number of eccentricities. Consequently, skin RRS and MPVUC at 9° are both reasonable biomarkers of macular carotenoid status that could be readily adapted to research and clinical settings.

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Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density

Cited by 18 publications

References 33 publications

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Effects of lutein supplementation in age-related macular degeneration

Correlations Between Macular, Skin, and Serum Carotenoids

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