Preliminary analysis of the antinociceptive activity of zerumbone

Sulaiman, Mohd Roslan; Perimal, Enoch Kumar; Zakaria, Zalina; Mokhtar, F.; Akhtar, M.N.; Lajis, Nordin H.; Israf, Daud Ahmad

doi:10.1016/j.fitote.2009.02.002

Cited by 56 publications

(52 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The central antinociceptive action of the AML was supported by the result obtained in the hot plate test as it is a sensitive and specific method used to demonstrate the involvement of central mechanism (Nemirovsky et al, 2001;Sulaiman et al, 2009). In the present study, oral administration of AML has shown a significant doserelated prolongation in the latency time when induced by the thermal nociceptive stimulus.…”

Section: Discussionsupporting

confidence: 75%

Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

Hamid¹,

Foong²,

Ahmad³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Ethanolic extract of Annona muricata L., Annonaceae, leaf (AML) was used to investigate its antinociceptive and anti-ulcerogenic activities and the involvement of the mechanism of ethanolic leaves extract of AML in various animal models. Antinociceptive activity of AML extract was done using acetic acid-induced abdominal writhing in mice, formalin test in rats and hot plate test in mice. Furthermore, the antiulcerogenic effect of AML extract was studied in ethanol-induced ulcer model in rats, ethanol-induced gastric lesions in L-NAME-pre-treated rats as well as ethanol-induced gastric lesions in NEM-pre-treated rats test model to determine its mechanism. AML exhibited signifi cant and dose-dependent antinociceptive activity. It also signifi cantly decreased the ulcerative lesion produced by ethanol in rats in a dose-dependent manner. Pre-treatment with N-ethymaleimide, a thiol blocker, including mucosal nonprotein sulfhydryl groups, reduced the anti-ulcerogenic effect of AML extract in the same ulcer model, suggesting that AML extract may have active substances such as tannins, fl avanoids and triterpenes that increase the mucosal nonprotein sulfhydryl group content.

show abstract

Section: Discussionsupporting

confidence: 75%

Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

Hamid¹,

Foong²,

Ahmad³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…It is interesting to note that the central antinociceptive effect of HFTP in the present study is strongly supported by the findings obtained from the hot-plate test, which is a specific test to elucidate the involvement of a central mechanism (Sulaiman et al, 2009). Our results demonstrated that HFTP (1 and 5 mg/kg; i.p.)…”

Section: Discussionsupporting

confidence: 85%

“…The possible involvement of the opioidergic system in HFTP-induced antinociception was determined using the formalin-induced paw licking and hot-plate tests as previously described (Mohamad et al, 2010;Sulaiman et al, 2009). Separate groups of animals (n = 6) were pretreated with a non-selective opioid receptor antagonist, naloxone (5 mg/kg, i.p.…”

Section: Involvement Of Opioid Receptorsmentioning

confidence: 99%

Hexanic fraction of turmeric powder attenuates murine model of induced nociception and its possible mechanisms of action

Suloon¹,

Mohamad²,

Lee³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

The current study was conducted to further examine the antinociceptive activity of hexane fraction of turmeric powder (HFTP) and to elucidate the possible mechanisms of action underlying its antinociceptive activity in various experimental models of chemical-and thermal-induced nociception. Materials and Methods: Acetic acid-induced abdominal constriction, hot-plate, formalin-, capsaicin-and glutamate-induced paw licking tests in mice were employed in the antinociceptive investigation of HFTP. In all experiments, HFTP was administered intraperitoneally at the doses of 0.1, 0.5, 1.0 and 5.0 mg/kg. In a separate group of experiments, the possible sedative and toxic effects of HFTP were tested in rota rod and preliminary acute toxicity tests, respectively. Results: It was demonstrated that HFTP exerted significant dose-dependent antinociceptive responses in the acetic acid-induced abdominal constriction, hot-plate, formalin-, capsaicin-and glutamate-induced paw licking tests. It was also demonstrated that pretreatment with naloxone, produced no significant effect on the antinociception induced by HFTP. Moreover, administration of HFTP shows no significant interference in locomotor activity of the rota rod test, and in the preliminary acute toxicity test, neither abnormal behaviours nor mortality were observed. Conclusion: Together, these results indicated that HFTP-induced antinociceptive activity at doses devoid of any detectable toxicity and sedative effects exerts pronounced peripheral and central antinociceptive effects, with no involvement of opioidergic system but possibly related to its ability to interact with TRPV1 receptors and the glutamatergic system.

show abstract

“…Earlier, we had isolated ZER from the MEZZ and tested this compound for its antinociceptive activity using the abdominal constriction and hot plate tests. ZER was found to exhibit significant antinociceptive activity in both tests; this antinociceptive effect was completely abolished by pretreatment with 5 mg/kg of naloxone, indicating the involvement of opioid receptors in the mediation of the central antinociceptive activity of the MEZZ [28] . This pattern of activity was also seen with the MEZZ, suggesting the involvement of ZER in the antinociceptive effect of the extract.…”

Section: Discussionmentioning

confidence: 88%

Antiinflammatory and Antinociceptive Activities of <i>Zingiber zerumbet </i>Methanol Extract in Experimental Model Systems

et al. 2010

Self Cite

View full text Add to dashboard Cite

Objective: The present study was carried out to determine the antiinflammatory and antinociceptive activities of a methanol extract of Zingiber zerumbet rhizomes (MEZZ) using various experimental model systems. Materials and Methods: The MEZZ was prepared by macerating oven-dried (50°C) powdered rhizomes (1.2 kg) of Z. zerumbet in 80% methanol in a ratio of 1:20 (w/v) for 48 h. The supernatant was collected, filtered and evaporated to dryness under reduced pressure (50°C) yielding approximately 21.0 g of the crude dried extract. The crude dried extract was stored at –20°C prior to use and was dissolved in normal saline (0.9% NaCl) immediately before administration at concentrations required to produce doses of 25, 50 and 100 mg/kg. Results: All dosages of MEZZ showed significant (p < 0.05) antiedema activity when assessed using the carrageenan-induced paw edema test and the cotton-pellet-induced granuloma test. The MEZZ exhibited significant (p < 0.05) antinociceptive activity when assessed by the writhing, hot plate and formalin tests. Pretreatment with naloxone (5 mg/kg) significantly decreased the latency of discomfort produced by the 100 mg/kg dose of MEZZ in the hot plate test. Conclusion: MEZZ produced antiinflammatory and antinociceptive activities which may involve the inhibition of bradykinin-, prostaglandin-, histamine- and opioid-mediated processes.

show abstract

Preliminary analysis of the antinociceptive activity of zerumbone

Cited by 56 publications

References 20 publications

Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

Hexanic fraction of turmeric powder attenuates murine model of induced nociception and its possible mechanisms of action

Antiinflammatory and Antinociceptive Activities of <i>Zingiber zerumbet </i>Methanol Extract in Experimental Model Systems

Contact Info

Product

Resources

About