Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

Hamid, Roslida Abdul; Foong, Chan; Ahmad, Zubair; Hussain, Mohd Khairi

doi:10.1590/s0102-695x2012005000001

Cited by 45 publications

(38 citation statements)

References 50 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were consistent results demonstrating the antinociceptive ( n = 2) effect of A. muricata in a rats and mice model using the ethanolic leaf extract at a dose range of 10–400 mg/kg. Chemopreventive effects of A. muricata were also demonstrated across four studies utilising mice model, with ethanolic and methanolic leaf extracts at a dose range of 30–400 mg/kg.…”

Section: Resultsmentioning

confidence: 82%

“…For human studies, author, publication year, study design, A. muricata formulation, origin, dosage, duration, study population, concurrent medication or therapy, sample size, biomarkers assessed, main outcomes and adverse effects were recorded. For pharmacokinetic studies, the author, publication year, animal tested, constituent analysed, study design, main [37] Rats; mice Ethanolic (Malaysia) 10-300 mg/kg (mice n = 48); (rats n = 24)…”

Section: Data Extractionmentioning

confidence: 99%

See 1 more Smart Citation

The safety and tolerability of Annona muricata leaf extract: a systematic review

Chan

McLachlan

Hanrahan

et al. 2019

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives Annona muricata, also known as graviola, soursop and guanabana, has been widely utilised for the treatment of a range of cancers. The mechanism of action and the efficacy of A. muricata and its constituents in the treatment of cancer have been comprehensively reviewed. The aim of this systematic review was to summarise the available literature that reports on factors related to the safety and tolerability of A. muricata leaf extract and its acetogenins. Methods In‐vitro, preclinical animal studies and human studies of any design written in any language were included. Studies that evaluated A. muricata leaf extract and its constituents were searched through the databases Pubmed, Medline and Embase from inception to April 2019. The elaborated item 4 of Consolidated Standards of Reporting Trials statement and Animals in Research: Reporting In vivo Experiments guidelines were used to evaluate the quality of the studies. Key findings The results suggest that A. muricata and its constituents have hepatoprotective, neurotoxic, antinociceptive, anti‐ulcerative and chemopreventive effects. The dose and duration used in animal studies demonstrating toxicity may not directly translate into the effects in humans. Studies included in this review were judged to be of medium to high quality. Conclusions The overall outcome of the current review suggests that A. muricata has a favourable safety and tolerability profile. Future studies investigating its use in people diagnosed with a range of cancers are warranted.

show abstract

Section: Resultsmentioning

confidence: 82%

Section: Data Extractionmentioning

confidence: 99%

The safety and tolerability of Annona muricata leaf extract: a systematic review

Chan

McLachlan

Hanrahan

et al. 2019

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Annona muricata is an evidently beneficial plant known for its diverse biological activities as antimicrobial, antidiabetic, anticancerous, noniceptive and others as reviewed by Arthur et al The anti-inflammatory effect of both the aqueous and ethanolic leaves extracts was shown by many references [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Histopathological Effects of the Annona muricata Aqueous Leaves Extract on the Liver and Kidneys of Albino Mice

Bitar¹,

Fakhoury²,

Fahmi³

et al. 2017

Transl Med

View full text Add to dashboard Cite

They showed anti-tumor effects in vivo and in vitro [17][18][19]. The essential oils of A. muricata leaves have parasiticidal, anti-diarrheal, rheumatological, and anti-neuralgic properties [20,21] AM water extract is commonly used in folk medicine to reduce inflammation as synthetic drugs have many side effects on liver and kidneys. The aim of this paper is to investigate the effect of AM extract against inflammation caused by a newly identified bacterial strain in our laboratory in albino mice. Materials and Methods Preparation of the water extract of Annona muricata leavesSterilized and shade air-dried Annona muricata leaves were purchased from USA from Nallife Company. AM leaves were of Thailand origin. Sixty grams of powdered AM leaves were soaked in 200 ml of boiling distilled water. Filtrate were extracted a second time with an additional 200 ml of boiling distilled water. The combined filtrate was then freezed-dried yielding a 2.43 g of brown, sticky precipitate that was stored at 4°C. Aliquot of extract residue were weighed and suspended in de-ionized distilled water to a final concentration of 34.2 mg/ml before use. AbstractAnnona muricata (AM) is a plant that is traditionally used for its various medicinal benefits. The present investigation aims at estimating the anti-inflammatory activity of AM leaf extract against peritonitis induced by Bacillus furmis. Albino mice (25-30 grams) were intra-peritoneally injected with 1.5 × 10 9 CFU Bacillus furmis and treated with either AM water extract (100 mg/kg) or combination of AM and aspirin. Control groups received only water. Mice were pre-treated with AM extract either two hours or 7 days prior to bacterial infection. Animals were sacrificed three days after bacterial infection. Livers and kidneys were removed and preserved in 10% formalin solution for histopathological studies or in Carnoys solution to assess level of glycogen in liver. The histopathological studies of animals treated with 100 mg/kg AME and 100 mg/kg aspirin showed a synergistic anti-inflammatory effect. However, the leaf extract alone exhibited different effect depending on the dose used. At high doses, AM leaf extract caused a toxic effect on both the liver and the kidney of mice, whereas at low dose it exhibited a protective effect. Therefore, we conclude that Annona muricata extract should be taken with precaution if to be used for extended period of time.

show abstract

“…PGs play a significantprotective role in the stomach by stimulating the synthesis and secretion of mucus and bicarbonate, increasing mucosal blood flow and promoting epithelial proliferation. The major mechanism via NSAIDs cause ulcers is the inhibition of PGs by the inhibition of COX, which isa key enzyme in the bio-synthesis of PGs (Hamid et al, 2012). So to avoid all these adverse reactions of the drugs, herbal remedies should be given to the ulcer patient to cure the ulcer.…”

Section: Discussionmentioning

confidence: 99%

Gastro-protective potential of Artemisia parvifloraon aspirin induced gastric ulcers in albino rabbits

Aslam¹,

Anwar²,

Javed³

et al. 2017

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Artemisia parviflora Roxb.(Asteraceae) has medicinal properties. This study evaluates the gastroprotective potential of A. parviflora seeds against aspirin induced ulcers in albino rabbits.Thirtysix rabbits were randomly divided into 6 equal groups (n = 6). Group 1 was control; group 2 received aspirin for 14 days; group 3 received omeprazole + aspirin for 14 days; groups 4, 5, and 6 received A. parviflora seed powder 250, 500, and 750 mg/kg, respectively along with aspirin, for 14 days. Total oxidant status (TOS), totalantioxidant capacity (TAC), malondialdehyde (MDA), and catalase (CAT) were determined to check the gastric damage. Ulcer score, gastric volume, gastric pH, and total acid output was also measured to determine gastroprotective potential of A. parviflora. A. parviflora seed powder exhibit gastroprotective potential with significant reduction in the ulcer score, acid output, and gastric volume while the pH of gastric mucosa increases significantly at the dose of 750 mg/kg when compared to aspirin treated group. Biochemical analysis showed a significant increase in TAC and CAT activity while it showed significant decrease in the levels of TOS and MDA which indicate reduction in gastric damage.A. parviflora seed powder proved to be gastroprotective at 250, 500 and 750 mg/kg with gastric protection of 47.5, 58.1, and 73.5%, respectively. It also has potent antioxidant properties.

show abstract

Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

Cited by 45 publications

References 50 publications

The safety and tolerability of Annona muricata leaf extract: a systematic review

The safety and tolerability of Annona muricata leaf extract: a systematic review

Histopathological Effects of the Annona muricata Aqueous Leaves Extract on the Liver and Kidneys of Albino Mice

Gastro-protective potential of Artemisia parvifloraon aspirin induced gastric ulcers in albino rabbits

Contact Info

Product

Resources

About