Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging and gating

Shimizu, Satoru; Matsuura, Tetsuya; Umezawa, M.; Hiramoto, Kazuo; Miyamoto, Naoki; Umegaki, Kikuo; Shirato, Hiroki

doi:10.1016/j.ejmp.2014.04.002

Cited by 29 publications

(22 citation statements)

References 7 publications

(9 reference statements)

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“…10 Because the increase of the proton energy causes the increase of the Bragg-peak range, water phantom greater heights were required to deduce the PDD without the cut-off. The height of the water phantom was extended up to 10 cm with the same diameter, and each location of the BUR was adjusted to include the proton's maximum dose level point according to the three different energies.…”

mentioning

confidence: 99%

Application of proton boron fusion reaction to radiation therapy: A Monte Carlo simulation study

Yoon

Jung

Suh

2014

Applied Physics Letters

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Three alpha particles are emitted from the point of reaction between a proton and boron. The alpha particles are effective in inducing the death of a tumor cell. After boron is accumulated in the tumor region, the emitted from outside the body proton can react with the boron in the tumor region. An increase of the proton's maximum dose level is caused by the boron and only the tumor cell is damaged more critically. In addition, a prompt gamma ray is emitted from the proton boron reaction point. Here, we show that the effectiveness of the proton boron fusion therapy was verified using Monte Carlo simulations. We found that a dramatic increase by more than half of the proton's maximum dose level was induced by the boron in the tumor region. This increase occurred only when the proton's maximum dose point was located within the boron uptake region. In addition, the 719 keV prompt gamma ray peak produced by the proton boron fusion reaction was positively detected. This therapy method features the advantages such as the application of Bragg-peak to the therapy, the accurate targeting of tumor, improved therapy effects, and the monitoring of the therapy region during treatment.

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mentioning

confidence: 99%

Application of proton boron fusion reaction to radiation therapy: A Monte Carlo simulation study

Yoon

Jung

Suh

2014

Applied Physics Letters

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“…112 A recent review paper 113 predicted the accelerated development of hardware and simple prototype systems within a few years and coupled systems integrated with gantries in a decade. Implementation of real-time monitoring of tumor position, which is currently achieved mostly by fluoroscopic imaging of fiducial surrogates, 114,115 with an on-board MR system will be a significant advancement for particle therapy. Recent work has additionally investigated the possibility of MR only particle therapy dose calculation by creating pseudo-CT images from MR images.…”

Section: Beyond Radiological Image Guidancementioning

confidence: 99%

Current state and future applications of radiological image guidance for particle therapy

Landry

Hua

2018

Medical Physics

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In this review paper, we first give a short overview of radiological image guidance in photon radiotherapy, placing emphasis on the fact that linac based radiotherapy has outpaced particle therapy in the adoption of volumetric image guidance. While cone beam computed tomography (CBCT) has been an established technique in linac treatment rooms for almost two decades, the widespread adoption of volumetric image guidance in particle therapy, whether by means of CBCT or in‐room CT imaging, is recent. This lag may be attributable to the bespoke nature and lower number of particle therapy installations, as well as the differences in geometry between those installations and linac treatment rooms. In addition, for particle therapy the so called shift invariance of the dose distribution rarely applies. An overview of the different volumetric image guidance solutions found at modern particle therapy facilities is provided, covering gantry, nozzle, C‐arm, and couch‐mounted CBCT as well different in‐room CT configurations. A summary of the use of in‐room volumetric imaging data beyond anatomy‐based positioning is also presented as well as the necessary corrections to CBCT images for accurate water equivalent thickness calculation. Finally, the use of non‐ionizing imaging modalities is discussed.

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“…For example, large marker recognition errors during low dose imaging can be reduced by image processing techniques [24,28]. The dynamic gating window technique [26] or management of the baseline shift [29] might also compensate for the variation of tumor motion and reduce toggling of the gate signals.…”

Section: Discussionmentioning

confidence: 99%

“…The resulting fluctuations in the gating signal can significantly reduce the gated irradiation efficiency in variable flat top phase synchrotron operation [21]. To improve the gated irradiation efficiency, we have developed a real-time-image gated proton beam therapy (RGPT) system [22][23][24] which has a new function, called the multiple gated-irradiation function [20,25]. The combination of variable flat top phase operation and multiple gated-irradiation function was realized in the first in RGPT.…”

Section: Introductionmentioning

confidence: 99%

Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique

et al. 2016

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(Naoki Miyamoto) Purpose:To find the optimum parameter of a new beam control function installed in a synchrotron-based proton therapy system. Methods:A function enabling multiple gated irradiation in the flat top phase has been installed in a real-time-image gated proton beam therapy (RGPT) system. This function is realized by a waiting timer that monitors the elapsed time from the last gate-off signal in the flat top phase. The gated irradiation efficiency depends on the timer value, T w . To find the optimum T w value, gated irradiation efficiency was evaluated for each configurable T w value. 271 gate signal data sets from 58 patients were used for the simulation. Results:The highest mean efficiency 0.52 was obtained in T W = 0.2 s. The irradiation efficiency was approximately 21% higher than at T W = 0 s, which corresponds to ordinary synchrotron operation. The irradiation efficiency was improved in 154 (57%) of the 271 cases. The irradiation efficiency was reduced in 117 cases because the T W value was insufficient or the function introduced an unutilized wait time for the next gate-on signal in the flat top phase. In the actual treatment of a patient with a hepatic tumor at T w = 0.2 s, 4.48 GyE irradiation was completed within 250 s. In contrast, the treatment time of ordinary synchrotron operation was estimated to be 420 s. Conclusions:The results suggest that the multiple gated-irradiation function has potential to improve the gated irradiation efficiency and to reduce the treatment time.

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Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging and gating

Cited by 29 publications

References 7 publications

Application of proton boron fusion reaction to radiation therapy: A Monte Carlo simulation study

Application of proton boron fusion reaction to radiation therapy: A Monte Carlo simulation study

Current state and future applications of radiological image guidance for particle therapy

Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique

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