1985
DOI: 10.1097/00005344-198500076-00024
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Prejunctional α2-Adrenoceptors and Norepinephrine Release in the Forearm of Normal Humans

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Cited by 27 publications
(12 citation statements)
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“…21 Clonidine also possesses peripheral analgesic properties in patients with sympathetically maintained pain, possibly because it reduces release of norepinephrine from prejunctional ␣ 2 -adrenoreceptors in the periphery. 22 Data from several clinical investigations support the importance of peripheral adrenergic receptors in the maintenance of sympathetically maintained pain. First, adrenergic blockade with intravenously (IV) administered phentolamine, 23 phenoxybenzamine, 24 or prazosin, 25 reduce pain.…”
Section: Discussionmentioning
confidence: 94%
“…21 Clonidine also possesses peripheral analgesic properties in patients with sympathetically maintained pain, possibly because it reduces release of norepinephrine from prejunctional ␣ 2 -adrenoreceptors in the periphery. 22 Data from several clinical investigations support the importance of peripheral adrenergic receptors in the maintenance of sympathetically maintained pain. First, adrenergic blockade with intravenously (IV) administered phentolamine, 23 phenoxybenzamine, 24 or prazosin, 25 reduce pain.…”
Section: Discussionmentioning
confidence: 94%
“…Despite controversial findings, the function of pre-junctional α 2 -adrenergic receptor may not be relevant to the physiological regulation of neuronal norepinephrine release in healthy subjects [Kiowski et al, 1985;; Aggarwal et al, 2001]. …”
Section: Sympathetic Regulation Of Vascular Function In Obesitymentioning
confidence: 99%
“…It could be argued that blockade of pre-junctional α 2 -adrenoreceptors by phentolamine and subsequent decrease in norepinephrine reuptake would confound interpretation of the results from this study. However, it has been demonstrated that auto-inhibitory feedback control by pre-junctional α 2 -adrenoreceptors does not significantly modulate norepinephrine release in the human forearm circulation [Kiowski et al, 1985]. …”
Section: Two Previous Studies By Egan Et Al Demonstrated Increased Fomentioning
confidence: 99%
“…Clonidine possesses peripheral analgesic properties in patients with sympathetically maintained pain, possibly because it reduces the release of norepinephrine from prejunctional 2 -adrenoceptors in the periphery [16]. We have previously shown that IVRA with lidocaine and the 2 -adrenergic agonist clonidine (1 g/kg) is an effective technique for managing both acute postoperative pain [17] and symptoms of CRPS [18].…”
Section: Introductionmentioning
confidence: 99%