Preirradiation Chemotherapy for Advanced Head and Neck Carcinomas

Chemotherapy in the Management of Advanced Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients: Theoretical and Practical Considerations

“…[19][20][21][22][23][24] Although there are some data suggesting that certain regimens of induction chemotherapy provide better or at least equivalent survival, multiple clinical trials have failed to show an improvement in tumor control or survival. 16,[25][26][27][28][29][30][31][32][33][34][35][36][37] Induction chemotherapy alone has largely been abandoned and, if used, is usually used as part of a program that includes concurrent chemotherapy and radiotherapy. The chemotherapy regimens most commonly used in induction include 5-fluorouracil (5-FU)/ cisplatin combinations.…”

“…Some trials have reported that patients treated with induction chemotherapy experienced a significantly reduced incidence of distant metastases when compared to patients treated with immediate surgery or radiotherapy alone 19–24 . Although there are some data suggesting that certain regimens of induction chemotherapy provide better or at least equivalent survival, multiple clinical trials have failed to show an improvement in tumor control or survival 16,25–37 …”

Induction chemotherapy for advanced head and neck cancers: A literature review

“…Oncovin (vincristine) has been added to cisplatin and bleomycin in induction regimens in attempts t o increase response rate with an anticipated minimal effect on toxicity. Kukla et al 42 reported a 65% overall response rate with no CRs after one cycle of cisplatin, oncovin, and bleomycin (COB) in patients with stages I11 and IV disease. Al-Sarraf et al,43 with a similar regimen, reported an overall response rate of 55% with a CR rate of 2.5%.…”