Mitomycin and Fluorouracil With Concomitant Radiotherapy in Head and Neck Cancer

Kaplan, Michael; Hahn, Seung S.; Johns, Michael E.; Stewart, F. Marc; Constable, William C.; Cantrell, Robert W.; Bailey, Byron J.

doi:10.1001/archotol.1985.00800060044004

Cited by 27 publications

(5 citation statements)

References 10 publications

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“…A total of 244 cases were analyzed for this review, including 210 patients with head and neck cancer and 34 21 51 Table 11. In all patients receiving 5-FU, the drug was administered as a continuous IV infusion over 24 hr in patients with gastrointestinal cancer or over 5 days in patients with head and neck cancer.…”

Section: Resultsmentioning

confidence: 99%

Vascular events in patients receiving high‐dose infusional 5‐fluorouracil‐based chemotherapy: The University of Chicago experience

Gradishar

Vokes

Schilsky

et al. 1991

Med. Pediatr. Oncol.

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In a retrospective review, 22 of a total of 244 patients (9%) patients with head and neck or gastrointestinal cancer who were treated with infusional 5-fluorouracil (5-FU)-based chemotherapy regimens experienced thrombotic vascular events. These events occurred concurrently with treatment or several months following the completion of therapy and consisted mainly of cardiac arrhythmias, myocardial infarction, sudden death, and thromboembolism. The temporal relationship of these vascular events to the time of treatment suggests that infusional 5-FU may have been the underlying cause.

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Section: Resultsmentioning

confidence: 99%

Vascular events in patients receiving high‐dose infusional 5‐fluorouracil‐based chemotherapy: The University of Chicago experience

Gradishar

Vokes

Schilsky

et al. 1991

Med. Pediatr. Oncol.

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“…Treatment of head and neck cancer with RT + 5-FU + MMC gave an initial high response rate with a CR of 27/44 (64%) (146). Later reports, however, in which patients were given RT with or without the same two drugs failed to show that chemotherapy added to the efficacy of RT alone (147,148).…”

Section: Head and Neck Cancermentioning

confidence: 99%

Mitomycin C: a clinical update

Bradner¹

2001

Cancer Treatment Reviews

304

175

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“…A complete sterilization rate of 77% in the primary site has been observed. 23 The complete response rate of 73% observed at 8 months after the completion of therapy has been a predictor of local control in our experience. There have been multiple attempts of chemoradiosensitization in advanced gynecologic malignancies (Table 2) and the local control rates in all studies has been encouraging.…”

Section: Discussionmentioning

confidence: 50%

A phase I-II trial of multimodality management of bulky gynecologic malignancy: Combined chemoradiosensitization and radiotherapy

et al. 1990

Cancer

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Between December 1983 and December 1987, there were 44 patients with bulky, nonresectable squamous cell carcinomas of the gynecologic tract (cervix, 36; vagina, eight) who were treated with concomitant chemotherapy and radiotherapy. Chemotherapy consisted of 5-fluorouracil (5-FU) 1g/m2 given by continuous intravenous infusion on days 1 through 4 and mitomycin C 10 mg/m2 given intravenously on day 1. External-beam irradiation was started on day 1 with a total calculated dose of 5000 cGy in 25 fractions employed. This was followed by brachytherapy. With a mean follow-up of 30.3 months and a median of 28 months, local control has been achieved in 32 of 44 patients (73%). The overall response rate was 88% (3-month partial response, 43%; 3-month complete response, 45%; 8-month partial response, 15%; 8-month complete response, 73%). Analysis of complications by Radiation Therapy Oncology Group (RTOG) criteria did not demonstrate an increase in acute or late complications.

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Mitomycin and Fluorouracil With Concomitant Radiotherapy in Head and Neck Cancer

Cited by 27 publications

References 10 publications

Vascular events in patients receiving high‐dose infusional 5‐fluorouracil‐based chemotherapy: The University of Chicago experience

Vascular events in patients receiving high‐dose infusional 5‐fluorouracil‐based chemotherapy: The University of Chicago experience

Mitomycin C: a clinical update

A phase I-II trial of multimodality management of bulky gynecologic malignancy: Combined chemoradiosensitization and radiotherapy

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