Preimplantation hormonal differences between the conception and non- conception menstrual cycles of 32 normal women

Baird, Donna D.; Wilcox, Allen J.; Weinberg, Clarice R.; Kamel, Freya; McConnaughey, D. Robert; Musey, Paul I.; Collins, Delwood C.

doi:10.1093/humrep/12.12.2607

Cited by 74 publications

(68 citation statements)

References 32 publications

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“…We also did not observe evidence of a greater proportion of women with unusually long luteal phases ( 42 SD above our population mean) in the groups with higher maternal cow milk consumption (data not shown). The slower drop in the E 1 3G:Pd3G ratio after ovulation, reflects sluggish functional (endocrine secretion) transition from the Graafian follicle to the corpus luteum, and may predict less fertile cycles (Baird et al, 1997). However, in the current study, we did not detect associations between exposure and other luteal phase variables associated with reduced conception rates, including midluteal Pd3G and E 1 3G levels (Baird et al, 1999;Baird et al, 1997).…”

Section: Discussioncontrasting

confidence: 81%

“…In fact, there was a suggestive trend towards increased midluteal Pd3G in women whose mothers drank 6-11 glasses of milk per week compared to those whose mothers drank 0-5 glasses per week (Table 4). Higher midluteal Pd3G has been associated with increased prevalence of conceptional menstrual cycles (Baird et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…The slower drop in the E 1 3G:Pd3G ratio after ovulation, reflects sluggish functional (endocrine secretion) transition from the Graafian follicle to the corpus luteum, and may predict less fertile cycles (Baird et al, 1997). However, in the current study, we did not detect associations between exposure and other luteal phase variables associated with reduced conception rates, including midluteal Pd3G and E 1 3G levels (Baird et al, 1999;Baird et al, 1997). In fact, there was a suggestive trend towards increased midluteal Pd3G in women whose mothers drank 6-11 glasses of milk per week compared to those whose mothers drank 0-5 glasses per week (Table 4).…”

Section: Discussionmentioning

confidence: 99%

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Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women

Luderer

Kesner

Fuller

et al. 2013

Environmental Research

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a b s t r a c tBackground: For 15 months in [1981][1982], the commercial milk supply on the Hawaiian island of Oahu was contaminated with heptachlor epoxide, a metabolite of the insecticide heptachlor, resulting in gestational and/or lactational exposure to offspring of women who drank cow milk during that period.Objective: To determine whether gestational and lactational exposure to heptachlor epoxide alters reproductive function and age at puberty in men or women.Methods: 457 participants were recruited from a prior high school enrollment sampling frame of 20,000 adults born during 1981-1982 who lived on Oahu since at least first grade. Number of glasses of cow milk consumed weekly by the mother during the participant's gestation was used as a surrogate measure of heptachlor epoxide exposure. Reproductive function measures included semen analyses; reproductive hormones or their metabolites in daily urine specimens for one menstrual cycle; serum reproductive hormone levels in both sexes; and reported ages of onset for pubertal milestones. Results: We observed no strong associations of heptachlor epoxide exposure during gestation and lactation with reproductive endpoints. In females, heptachlor epoxide exposure was associated with longer luteal phase length and slower drop in the ratio of estradiol to progesterone metabolites after ovulation. In males, heptachlor epoxide exposure was weakly associated with higher serum follicle stimulating hormone and luteinizing hormone concentrations, but no dose-response relationship was apparent. Conclusions:The results provide limited evidence that gestational and lactational exposure to heptachlor epoxide, due to milk contamination on Oahu in 1981-1982, resulted in clinically significant disturbances of reproductive function in men or women.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women

Luderer

Kesner

Fuller

et al. 2013

Environmental Research

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“…An important factor in the establishment of early pregnancy appears to be the timing and rate of increase in the secretion of CG that is highly correlated with a rise in progesterone levels in peripheral circulation (42). Insufficient progesterone production during early pregnancy is correlated with the potential for early or recurrent pregnancy loss in women (6,7,27,47). Thus, endocrine mechanisms that potentiate the synthesis of CG subunits and CG secretion are essential for the establishment of pregnancy.…”

mentioning

confidence: 99%

Role of the Cyclic AMP Response Element Binding Complex and Activation of Mitogen-Activated Protein Kinases in Synergistic Activation of the Glycoprotein Hormone α Subunit Gene by Epidermal Growth Factor and Forskolin

Roberson

Ban

Zhang

et al. 2000

Molecular and Cellular Biology

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The aim of these studies was to elucidate a role for epidermal growth factor (EGF) signaling in the transcriptional regulation of the glycoprotein hormone ␣ subunit gene, a subunit of chorionic gonadotropin. Studies examined the effects of EGF and the adenylate cyclase activator forskolin on the expression of a transfected ␣ subunit reporter gene in a human choriocarcinoma cell line (JEG3). At maximal doses, administration of EGF resulted in a 50% increase in a subunit reporter activity; forskolin administration induced a fivefold activation; the combined actions of EGF and forskolin resulted in synergistic activation (greater than eightfold) of the ␣ subunit reporter. Mutagenesis studies revealed that the cyclic AMP response elements (CRE) were required and sufficient to mediate EGF-forskolin-induced synergistic activation. Chorionic gonadotropin (CG) is a heterodimeric glycoprotein hormone consisting of an ␣ subunit common to other glycoprotein hormone family members noncovalently linked to a CG-specific ␤ subunit (58). CG is synthesized and secreted by placental syncytiotrophoblast cells during the first trimester of pregnancy in women and nonhuman primates. CG is a luteotropin required for maintenance of progesterone production by the ovarian corpus luteum in early gestation. An important factor in the establishment of early pregnancy appears to be the timing and rate of increase in the secretion of CG that is highly correlated with a rise in progesterone levels in peripheral circulation (42). Insufficient progesterone production during early pregnancy is correlated with the potential for early or recurrent pregnancy loss in women (6, 7, 27, 47). Thus, endocrine mechanisms that potentiate the synthesis of CG subunits and CG secretion are essential for the establishment of pregnancy. Despite the clear importance of CG to early pregnancy, the specific ligands and signaling mechanisms that regulate the expression of CG subunit genes in placental cells have not been fully elucidated.The ␣ subunit of the glycoprotein hormones is a unique and useful transcriptional model for the study of tissue-specific gene expression because the ␣ subunit gene is expressed in placental and pituitary cells, albeit by various mechanisms. Analysis of the architecture of the ␣ subunit promoter revealed the presence of multiple promoter elements that are required for transcriptional regulation. These include the pituitary glycoprotein hormone basal element, which binds members of the LIM class of homeobox-containing proteins (67,71,72); the ␣ basal element (32); the gonadotrope-specific element, which binds steroidogenic factor 1 (9, 36); the upstream regulatory element (URE) (12,26,38,59); the GATA element, which binds several GATA factors (75); the dual tandem cyclic AMP (cAMP) response elements (CREs), which bind CRE binding protein (CREB) (5,10,12,13,22,25,32,35,52,59,74); the junctional regulatory element (JRE) (4, 12); and a unique CAAT box (12,40). Extensive mutagenesis studies have begun to unravel the specific requirements f...

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“…All women had maintained regular menstrual cycles for at least 6 months before the study. Levels of ovarian steroid hormones produced in menstrual cycles are both important determinants of fecundity (5,48) and are related to risk of several diseases, especially in postmenopausal years (8). Cumulative lifetime levels of sex-steroid hormones are implicated in development of hormonedependent cancers (1)(2)(3)(4).…”

Section: Discussionmentioning

confidence: 99%

CYP17Genotypes Differ in Salivary 17-β Estradiol Levels: A Study Based on Hormonal Profiles from Entire Menstrual Cycles

Jasieńska¹,

Kapiszewska

Ellison

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Variation in the levels of sex-steroid hormones results from differences in developmental conditions, adult lifestyle, and genetic polymorphism. Genes involved in sex-steroid biosynthesis have been implicated to influence levels of hormones in premenopausal women, but the results were inconclusive. We tested variation among women in levels of salivary estradiol (E 2 ) corresponding to CYP17 genotypes. CYP17 encodes cytochrome P450c17A, which mediates two enzymes important in E 2 synthesis. In contrast to the earlier studies that relied on one or a few samples for assessing the E 2 levels of an individual woman, our study is based on daily collected saliva samples for one entire menstrual cycle. Sixty Polish women, ages 24 to 36 years, with regular menstrual cycles and no reported fertility problems participated in the study. Women with A2/A2 genotype had 54% higher mean E 2 levels than women with A1/A1 genotype (P = 0.0001) and 37% higher than women with A1/A2 genotype (P = 0.0008). Heterozygous A1/A2 women had 13 % higher E 2 levels than homozygous A1/A1 women (but this difference was significant only in a nonparametric test). Levels of E 2 during the day with highest E 2 (day À1) were 72% higher in A2/A2 compared with A1/A1 (P = 0.01) and 52 % higher compared with A1/A2 (P = 0.03). Our results suggest that CYP17 genotype may serve as a biomarker of endocrine function in women of reproductive age. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2131 -5)

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Preimplantation hormonal differences between the conception and non- conception menstrual cycles of 32 normal women

Cited by 74 publications

References 32 publications

Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women

Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women

Role of the Cyclic AMP Response Element Binding Complex and Activation of Mitogen-Activated Protein Kinases in Synergistic Activation of the Glycoprotein Hormone α Subunit Gene by Epidermal Growth Factor and Forskolin

CYP17Genotypes Differ in Salivary 17-β Estradiol Levels: A Study Based on Hormonal Profiles from Entire Menstrual Cycles

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