Preimplantation genetic diagnosis in Saudi Arabia: parents' experience and attitudes

Alsulaiman, Ayman; Al‐Odaib, Ali; Rijjal, Al; Hewison, Jenny

doi:10.1002/pd.2532

Cited by 23 publications

(34 citation statements)

References 17 publications

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“…In this review we found strong evidence that couples experienced dissonance when addressing the issue of disposal of affected embryos (Katz et al, 2002;Alsulaiman et al, 2010;Karatas et al, 2010). Stress was caused by comparing their much loved affected children with affected embryos, which they were prepared to discard.…”

Section: Emotional Labourmentioning

confidence: 94%

“…This reluctance to have PND was supported by other studies, with only 37% of couples in Lavery et al's paper (2002) (from the UK and Spain) deciding to undergo PND. Alsulaiman et al (2010) showed that 52% of Saudi Arabian PGD couples had no concerns about a confirmatory PND, leaving 48% who did have concerns. This result is similar to the findings of Katz et al (2002) where 49% of couples in this Australian study were concerned about the recommendation to have PND.…”

Section: Choices and Uncertaintymentioning

confidence: 97%

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The evidence base regarding the experiences of and attitudes to preimplantation genetic diagnosis in prospective parents

2015

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Section: Emotional Labourmentioning

confidence: 94%

Section: Choices and Uncertaintymentioning

confidence: 97%

The evidence base regarding the experiences of and attitudes to preimplantation genetic diagnosis in prospective parents

2015

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“…For instance, the issue of termination is not widely accepted in the society [Albar, 1999]. Pre-implantation genetic diagnosis is not easily accessible [Alsulaiman et al, 2010]. Finally, premarital screening currently only covers sickle cell disease and b-thalassemia [Alhamdan et al, 2007], which recently showed a significant (>5-fold) increase in the frequency of voluntary cancellation of marriage proposals among at-risk couples from 9.2% to 51.9% over a 6-year period [Memish and Saeedi, 2011].…”

Section: Concept Of Preventionmentioning

confidence: 99%

Map of autosomal recessive genetic disorders in Saudi Arabia: Concepts and future directions

Al‐Owain

Alzaidan

Al‐Hassnan

2012

American J of Med Genetics Pt A

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Saudi Arabia has a population of 27.1 million. Prevalence of many autosomal recessive disorders is higher than in other known populations. This is attributable to the high rate of consanguineous marriages (56%), the tribal structure, and large family size. Founder mutations have been recognized in many autosomal recessive disorders, many of which are overrepresented within certain tribes. On the other hand, allelic heterogeneity is also observed among common and rare autosomal recessive conditions. With the adoption of more advanced molecular techniques in the country in recent years in conjunction with international collaboration, the mapping of various autosomal recessive disorders has increased dramatically. Different genetic concepts pertinent to this highly inbred population are discussed here. Addressing such genetic disorders at the national level will become a cornerstone of strategic health care initiatives in the 21st century. Current efforts are hampered by many socio-cultural and health care related factors. Education about genetic diseases, establishment of a "national registry" and mutational database, and enhanced healthcare access are crucial for success of any preventative campaign.

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“…PGD is permissible in Islam provided that the gametes are from the husband and wife. 12 PGD may be socially a better option and more easily acceptable than PD in Muslim countries as parents do not have to undergo the option of terminating the pregnancy. 13 However, clinically it involves a considerable hormonal treatment for the woman and artificial insemination may cause an increase in chromosomal defects.…”

Section: Discussionmentioning

confidence: 95%

Primary Prevention of Hemoglobinopathies by Prenatal Diagnosis and Selective Pregnancy Termination in a Muslim Country: Oman

Hassan

Bakker

Harteveld

et al. 2014

Thalassemia Reports

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Hemoglobinopathies (HBP) are the most common genetic disorder in Oman and are in need of prevention programs due to the high incidence of -thalassemia major and sickle cell disease. Prenatal diagnosis (PD) and selective pregnancy termination is shown to be the most effective prevention tool for the control of HBP. However, PD is not available in Oman thus far because abortion is subject to religious, cultural and ethical issues. We have examined the attitude of a number of Omani HBP carrier couples towards prenatal diagnosis and selective abortion. We have interviewed 35 couples at risk visiting the main premarital clinic in Muscat between Jan 2011 and Jan 2012. Couples were interviewed using a pre-structured questionnaire. The majority would have accepted prenatal diagnosis (94%) if the service would be available in the country but pregnancy termination was greatly influenced by religious values.

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Preimplantation genetic diagnosis in Saudi Arabia: parents' experience and attitudes

Abstract: PGD might be considered for a range of conditions in Saudi Arabia. However, it is not an easy option, and couples must be selected and counselled appropriately.

Cited by 23 publications

References 17 publications

The evidence base regarding the experiences of and attitudes to preimplantation genetic diagnosis in prospective parents

The evidence base regarding the experiences of and attitudes to preimplantation genetic diagnosis in prospective parents

Map of autosomal recessive genetic disorders in Saudi Arabia: Concepts and future directions

Primary Prevention of Hemoglobinopathies by Prenatal Diagnosis and Selective Pregnancy Termination in a Muslim Country: Oman

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