Pregnane Glycosides

A new pregnane glycoside fromMarsdenia royleias potential antioxidant and antidyslipidemic agents

“…119-1238C, [a] D þ10, C 37 H 58 O 12 , FAB-MS m/z 756 [M þ þNa þ K], responded positively to Liebermann-Burchardt [10], xanthydrol [10], Keller-Killiani [10], and Feigl tests [2], indicating it to be a steroidal glycoside of 2,6-dideoxy and normal hexose(s). The presence of two anomeric protons and carbons at d 5.…”

“…An important mass ion fragment that arose by rearrangement involving migration of the acetyl group of S2 at C-3 to C-1 of the same sugar, after the radical ion fission of C1ZC2 bond [2], resulting in the cleavage of the terminal sugar appeared at m/z 553. This fragment further confirmed that the esterified D-canarose is the terminal sugar.…”

“…Asclepiadaceae family plants are a rich source of cardiac [1] and pregnane glycosides [2]. These pregnanes and their glycosides, which are known to possess antitumor and anticancer activities [2,3], have also shown antiproliferative activity [4,5] on J774, A1, HEK-293 and WEHI-164 cell lines.…”

“…These pregnanes and their glycosides, which are known to possess antitumor and anticancer activities [2,3], have also shown antiproliferative activity [4,5] on J774, A1, HEK-293 and WEHI-164 cell lines. Marsdenia roylei (family Asclepiadaceae) is widely used in ayurveda and unani medicine.…”

Two new pregnane glycosides from soft coral Cladiella krempfi

“…Previous chemical investigation on this genus led to the isolation of members of structural diversity metabolites, involving cembranes [1,2], eunicellane diterpenes [3 -12], sesquiterpenes [13], steroids and glycolipids [14 -17]. Pregnane-type steroids are a class of natural products mainly occurring in soft corals, and various plant species mostly belonging to the Asclepiadaceae family [19]. Zheng et al have isolated two anti-tumour active pregnane glycosides from Cladiella krempfi [16] and two pregnenones from Cladiella sp.…”