Pregnancy β1 glycoprotein and chorionic gonadotrophin in the serum of patients with trophoblastic and non-trophoblastic tumours

The diagnostic value of circulating trophoblast-specific β1-glycoprotein (TSG) in cancer patients

“…The detection of TSG in the sera of 7000 of patients with gestational trophoblast tumours, including uterine choriocarcinomas, suggests that this immunochemical test for TSG may have diagnostic value. The correlation of TSG and human chorionic gonadotrophin (hCG) release by gestational trophoblast tumours has been discussed by a number of authors (Tatarinov et al, 1976;Bagshawe et al, 1978;Searle et al, 1978;Seppala et al, 1978;Than et al, 1979). From these data it would be reasonable to assume that TSG assays may play an ancillary role to hCG assays for such lesions.…”

Immunohistochemical and Radioimmunological Determination of β-HCG and Pregnancy-Specific β₁_-Protein in Seminomas

“…Several authors [1,17,20,25,26,29] have so far reported about elevated serum SPi levels in teratocarcinomas.…”

Trophoblast-Specific Beta₁-Glycoprotein as a Marker for Pregnancy and Malignancies

“…Summarizing tire collaborative study, Bagsltawe et al (7) suggested that there is some dissociation between TSG and HCG levels in the serum of patients with gestational trophoblastic tumours and especially in patients with malignant teratomas. Probably, this dissociation is due to a different synthesis and metabo lism of TSG and HCG, although these proteins are produced by the same cells of both normal and malignant trophoblasts.…”