The diagnostic value of circulating trophoblast-specific β1-glycoprotein (TSG) in cancer patients

Tatarinov, Yu. S.

doi:10.1038/bjc.1980.147

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…For patients with breast cancer the SP1 concentration was of the same level as that in women with benign tumours. No values above 3 pgl-1 were found which agreed with other studies (Bremmer et al, 1981;Rosen et al, 1982), but conflicted with studies previously reported to have from 22% to 29% of SP1 determinations >>3ygl-' (Searle et al, 1978;Wurz, 1979) and 8% to 11% >l0pgI-' (Wiirz, 1979;Tatarinov, 1980). In a less sensitive assay with a detection limit of lOpgl-1, SP1 was observed in only one of 42 patients with malignant breast disorders (Grudzinskas et al, 1980).…”

supporting

confidence: 68%

“…However, SP1 does not seem to be specific to pregnancy since it has been detected by radioimmunoassay in sera from 3 to 54% of healthy persons (Searle et al, 1978;Wurz, 1979;Tatarinov, 1980) and in sera from patients with a variety of malignant diseases, for instance 8-55% of breast cancer patients (Searle et al, 1978;Wiirz, 1979;Tatarinov, 1980), depending on the detection limit of the assay. By means of a histological immunoperoxidase technique SP1 has been demonstrated in 37-76% of malignant tumours of the breast (Horne et al, 1976;Inaba et al, 1980;Walker, 1981).…”

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confidence: 99%

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Pregnancy-specific β 1-glycoprotein (SP1) in serum and tissue from patients with benign and malignant breast tumours

Sørensen¹,

Andersen²,

Nørgaard³

1984

Br J Cancer

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confidence: 68%

mentioning

confidence: 99%

Pregnancy-specific β 1-glycoprotein (SP1) in serum and tissue from patients with benign and malignant breast tumours

Sørensen¹,

Andersen²,

Nørgaard³

1984

Br J Cancer

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Placental proteins in high-grade urothelial neoplasms. An immunohistochemical study of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta-1-glycoprotein

Campo

Algaba

Palacı́n

et al. 1989

Cancer

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We examined the presence of human chorionic gonadotropin (HCG) in 16 low-grade and 47 high-grade urothelial neoplasms, including two cases with trophoblastic-like differentiation. In HCG-positive tumors, the presence of human placental lactogen (HPL) and pregnancy-specific beta-1-glycoprotein (SP-1) also was assessed. HCG immunoreactive cells were found in nine of the 47 high-grade tumors (19%), whereas none of the low-grade tumors were positive for HCG. This hormone was predominantly detected in the most undifferentiated and pleomorphic areas; however, HCG-positive cells also were found in areas of carcinoma in situ and well-differentiated transitional cell carcinoma in two cases. The serum HCG level was increased in two of the four cases studied. HPL and SP-1 immunoreactive cells were observed in seven and five cases, respectively, and it was found that tumors positive for SP-1 also were positive for HPL. Five tumors, including the two with trophoblastic differentiation, contained the three placental proteins. The HPL and SP-1 immunostained cells were usually found in the same areas of the tumor that were positive for HCG, but there was always a lower number of HPL and SP-1 immunoreactive cells than HCG immunoreactive cells. In one case, HPL and SP-1 could be found in areas of well-differentiated transitional cell carcinoma. These findings suggest that the morphologic and functional trophoblastic differentiation in urothelial carcinomas is a progressive phenomenon evolving from transitional cell carcinomas.

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Immunochemistry of Human Teratocarcinoma Stem Cells

Andrews

Damjanov

1985

Monoclonal Antibodies in Cancer

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The diagnostic value of circulating trophoblast-specific β1-glycoprotein (TSG) in cancer patients

Cited by 6 publications

References 10 publications

Pregnancy-specific β 1-glycoprotein (SP1) in serum and tissue from patients with benign and malignant breast tumours

Pregnancy-specific β 1-glycoprotein (SP1) in serum and tissue from patients with benign and malignant breast tumours

Placental proteins in high-grade urothelial neoplasms. An immunohistochemical study of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta-1-glycoprotein

Immunochemistry of Human Teratocarcinoma Stem Cells

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