Pregnancy with a Normal live Foetus and a Partial Molar Placenta - An Extremely Rare Condition

Khanom, R; Khatun, Kashefa; Akter, Saleha

doi:10.3329/jdmc.v18i1.6313

Cited by 5 publications

(5 citation statements)

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“…After the delivery, it is mandatory to check the patient until there have been 12 consecutive months of negative hCG levels. In conclusion, in every case of molar pregnancy suspect for a normal fetus, adequate counseling of the patient and a strict follow-up during and after pregnancy for the risk of persistence of the trophoblastic pathology are necessary [18–20].…”

Section: Resultsmentioning

confidence: 99%

A partial molar pregnancy associated with a fetus with intrauterine growth restriction delivered at 31 weeks: a case report

et al. 2019

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Introduction Molar pregnancies belong to a group of diseases classified as gestational trophoblastic diseases, which result from an altered fertilization. Partial molar pregnancy with a live fetus is a very rare condition, occurring in 0.005 to 0.01% of all pregnancies; it presents a challenging diagnosis, especially when clinical signs are almost completely absent. Case presentation Here we report a rare case of partial molar pregnancy in which a normal-appearing male fetus with diploid karyotype was delivered at 31 weeks gestation by a 37-year-old white woman. The pregnancy was characterized by an episode of threatened abortion in the first trimester and an ultrasonographic diagnosis of intrauterine growth restriction. Our patient did not report any suspicious symptoms for trophoblastic disease. Due to impaired umbilical artery velocimetry with an absence of the diastolic phase, she underwent an emergency caesarean section at 31 weeks and delivered an 880 g male baby. The male baby was normal without any complications at 3-month and 12-month follow-up and the mother had no evidence of recurrence after 3 and 12 months of follow-up. Pathological examination of the placenta showed changes of partial hydatidiform mole. Conclusion Partial molar pregnancy with a live fetus is a very rare condition that presents a challenging diagnosis. Recognizing it is of primary importance for patient care and the placenta should always be investigated at birth, especially in a newborn with intrauterine growth restriction.

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Section: Resultsmentioning

confidence: 99%

A partial molar pregnancy associated with a fetus with intrauterine growth restriction delivered at 31 weeks: a case report

et al. 2019

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“…A chorionic villous biopsy could be done if a live fetus is present, to confirm the diagnosis and to differentiate between a partial mole and complete mole: it has been reported that the latter has approximately 20% tendency to become an invasive mole or even a choriocarcinoma, while the risk was lower for partial moles (14,16). Follow-up BhCG during and following pregnancy in order to early identify cases of persistent trophoblastic disease, invasive mole and choriocarcinoma is necessary (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Severe fetal anaemia resulting from a widely metastatic antenatal choriocarcinoma

Khalil

Al-Inizi

James

2023

Preprint

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“…Some factors may influence survival of fetus in PHM: (1) normal karyotype of fetus, (2) smaller size of grape tissue of placenta, (3) the rate of molar degeneration, (4) nonanemia state of fetus, and (5) the absence of maternal complications such as preeclampsia, thyrotoxicosis, and profuse vaginal bleeding 12 . Our case described some of these factors, such as diploid karyotype, few and focal extent of hydatidiform tissue of placenta, low rate of molar degeneration, and the absence of fetal anemia.…”

Section: Discussionmentioning

confidence: 99%

Partial hydatidiform mole and coexistent live fetus with placenta previa: a case report

Santoso

Anton

Nugrahani

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and importance: Partial molar pregnancy with a coexistent live fetus is very rare. This type of mole mostly ends in the early termination of pregnancy due to an abnormally developed fetus. Case presentation: Here, we report a case of a 24-year-old Indonesian woman with an ultrasonographic appearance of partial hydatidiform mole with initial placenta covering the internal uterine ostium in the late first trimester which then became marginal placenta previa in the third trimester. The woman decided to continue the pregnancy after considering the risks and benefits. The normal anatomy of the premature infant was vaginally delivered alive with a large and hydropic placenta. Clinical discussion: Proper diagnosis, management, and monitoring remain challenging as this case is still rarely reported. Although embryos from partial mole forms generally do not survive since the first trimester, our case reported the singleton pregnancy with the coexistent normal fetus and the partial mole characteristic of the placenta. Diploid karyotype, few and focal extent of hydatidiform tissue of placenta, low rate of molar degeneration, and the absence of fetal anemia hypothesized as the factors that influenced survival of the fetus. There were two maternal complications such as hyperthyroidism and frequent vaginal bleeding without subsequent anemia in this patient. Conclusions: A rare case of partial hydatidiform mole coexistent with a live fetus with placenta previa was reported in this study. There were also maternal complications. Thus, prompt and regular monitoring of maternal and fetal condition holds an important role.

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Pregnancy with a Normal live Foetus and a Partial Molar Placenta - An Extremely Rare Condition

Cited by 5 publications

References 1 publication

A partial molar pregnancy associated with a fetus with intrauterine growth restriction delivered at 31 weeks: a case report

A partial molar pregnancy associated with a fetus with intrauterine growth restriction delivered at 31 weeks: a case report

Severe fetal anaemia resulting from a widely metastatic antenatal choriocarcinoma

Partial hydatidiform mole and coexistent live fetus with placenta previa: a case report

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