Pregnancy toxemia in a flock of sheep

Saun, Robert J. Van

doi:10.2460/javma.2000.217.1536

Cited by 63 publications

(50 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Esta alteração é sugestiva de que a habilidade do ϐígado de secretar este composto no sangue como lipoproteína (VLDL) está comprometida, induzindo desta maneira o acúmulo de gordura hepática. Esta modiϐicação metabólica associada aos valores elevados do AGNE e a alta ocorrência das ovelhas apresentando escore corporal elevado, acima de três, contribui para o desencadeamento da enfermidade (Van Saun 2000).…”

Section: Discussionunclassified

“…Com relação a concentração para triglicerídeos, que se manteve dentro dos valores de referência para espécie (Kaneko et al 2008), estes achados se assemelham ao relatado por Van Saun (2000), que não encontrou também alterações nos índices deste componente em ovelhas com toxemia da prenhez. Entretanto, diferenças foram relatadas por Barakat et al (2007) em cabras com cetose, que relataram valores baixos de triglicerídeos e fosfolipídios, e concluíram que são resultados da redução do apetite nos animais com hipercetonemia.…”

Section: Discussionunclassified

“…Com relação à elevação da proteína total sérica, os achados se comparam ao encontrado em outros trabalhos, que justiϐicam esta alteração em função dos diferentes graus de desidratação encontrados nos animais acometidos, condição esta observada nas ovelhas com TP (Cantley et al 1991, Andrews et al 1996, Van Saun 2000, Smith & Sherman 2009). Os achados diferem dos relatados por Yarin & Ceftci (2009) em ovelhas acometidas com a doença, em que reduções nos seus valores foram encontradas e concluíram esta modiϐicação pelo comprometimento da função hepática, em função da redução da síntese da albumina.…”

Section: Discussionunclassified

See 2 more Smart Citations

Indicadores bioquímicos e hormonais de casos naturais de toxemia da prenhez em ovelhas

Santos¹,

Mendonça

Filho³

et al. 2011

Pesq. Vet. Bras.

View full text Add to dashboard Cite

Toxemia da prenhez é considerada um transtorno metabólico de grande impacto econômico na produção de ovinos, porém as particularidades de repercussão sistêmicas deste distúrbio ainda são pouco esclarecedoras. O presente estudo teve por objetivo avaliar o perfil bioquímico e hormonal de 77 ovelhas com diagnóstico clínico de toxemia da penhez e comparar os achados laboratoriais de acordo com a resolução clínica dos animais, alta hospitalar (G1) e aqueles que morreram (G2). A manifestação clinica da doença foi observada no período do pré-parto em 100% dos animais, destes 66,2 % (n=51) receberam alta clínica e 33,8% (n=26) morreram. Dos casos de toxemia da prenhez estudados havia gestação múltipla em 55,8%. Dentre os parâmetros estudados, cortisol, uréia, AST e CK estavam mais elevados no G2 em relação ao G1 com diferenças significativas (P<0,05). Foi encontrado aumento nas concentrações de glicose plasmática, frutosamina, albumina, creatinina, ß-hidroxubutirato, ácido graxo não esterificado e L-lactato, porém não houve diferenças entre os grupos (P>0,05). Não ocorreram alterações nas taxas de colesterol e triglicerídios. Houve redução nos índices da insulina, não havendo diferenças entre G1 e G2 (P>0,05). Todas as ovelhas apresentaram cetonúria e acidúria.

show abstract

Section: Discussionunclassified

See 1 more Smart Citation

Indicadores bioquímicos e hormonais de casos naturais de toxemia da prenhez em ovelhas

Santos¹,

Mendonça

Filho³

et al. 2011

Pesq. Vet. Bras.

View full text Add to dashboard Cite

show abstract

“…Insufficient pancreatic β-cell function is a known factor of pathogenesis. However, only few data are available on the endocrine aspects of this disease (Harmon, 1990;Henze et al, 1998;Van Saun, 2000), and to the best of our knowledge the subsequent reproductive performance of the survivors has not been studied yet.…”

mentioning

confidence: 99%

Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season

Kulcsár¹,

Dankó²,

Delavaud³

et al. 2006

Acta Veterinaria Hungarica

View full text Add to dashboard Cite

Ketosis was diagnosed in a flock of Merino ewes that conceived from synchronised oestrus in the early autumn period. On day 140 of pregnancy the ewes were sampled for determination of βOH-butyrate (BHB), AST, glucose, nonesterified fatty acids (NEFA), total cholesterol (TCH), insulin, T 4 , T 3 , cortisol, IGF-1 and leptin. The results were evaluated according to the number of fetuses born some days later and the presence of hyperketonaemia (BHB: ≥ 1.60 mmol/l). In May, about 3 months after lambing, cyclic ovarian function was induced (Cronolone + eCG), and the ewes were inseminated artificially (AI) 48 h after the removal of gestagen-containing sponge. At the time of AI and 10 days later blood samples were collected again to check the plasma levels of the same constituents as previously (in samples taken at AI), and to monitor the ovarian response by assaying progesterone (in both samples). On day 140 of gestation significantly lower BHB levels were detected in dams with single (n = 41) than in those with twin (n = 57) pregnancies. Hyperketonaemia was found only in ewes bearing twins (n = 27). These animals had higher NEFA and cortisol, and lower TCH, insulin, IGF-1, leptin and T 3 levels than their normoketonaemic twin-bearing flockmates, and those with single pregnancy. The blood glucose concentrations varied within a wide range, and the means of groups did not exhibit any significant differences. The formerly hyperketonaemic individuals were characterised by lower leptin level 3 months after lambing, and they showed a poorer response to the cycle-induction procedure than the others. The non-responders had lower IGF-1 and leptin levels than those ovulated after this treatment. It was concluded that the subclinical form of ovine ketosis is characterised by complex endocrine altera-

show abstract

“…gestational ketosis) caused by negative energy balance in late gestation is commonly observed in ewes and does (Henze et al, 1998;Rook, 2000;Van Saun, 2000;Kulcsar et al, 2006), occasionally in beef cows (Rook, 2000), and also in monogastric species (rabbits, guinea pigs, dogs and in ferrets; Bell, 1997;Pare and Murphy, 1997;O'Rourke, 1997;Batchelder et al, 1999;Dalrymple, 2004;Lewington, 2007). The background of the disease is the result of the fetal carbohydrate-or energy-demand exceeding maternal supply during the last trimester of pregnancy.…”

mentioning

confidence: 99%

Metabolic and endocrine characteristics of pregnancy toxemia in the ferret

2009

View full text Add to dashboard Cite

Metabolic and endocrine characteristics of pregnancy toxemia are well documented in small ruminants, but less known in other species. The objective of this study was to measure plasma levels of certain metabolites and metabolic hormones related to the energetic status in blood from sick and healthy, non-pregnant (control) ferrets. Blood was collected from moribund, hypothermic, late pregnant females suffering from pregnancy toxemia (n = 4) and from healthy female ferrets (n = 14) to measure glucose, ketone (βOH-butyrate, BHB), insulin, thyroxine (T 4 ) and 3,3' ,5-triiodothyronine (T 3 ) concentrations. In contrast to healthy animals, hypoglycemia, hyperketonemia, hypoinsulinemia and decreased T 4 and T 3 levels were detected in females with pregnancy toxemia and necropsy showed excessive hepatic lipidosis. In summary, it can be concluded that pregnancy toxemia caused by a negative energy balance in ferrets resembles the late-gestational hyperketonemia of twin-pregnant ewes, and moreover that similar endocrine changes may occur.Keywords: gestational ketosis; insulin; thyroxine (T 4 ); 3,3' ,5-triiodo-thyronine (T 3 ) Pregnancy toxemia (syn. gestational ketosis) caused by negative energy balance in late gestation is commonly observed in ewes and does (Henze et al

show abstract

Pregnancy toxemia in a flock of sheep

Cited by 63 publications

References 8 publications

Indicadores bioquímicos e hormonais de casos naturais de toxemia da prenhez em ovelhas

Indicadores bioquímicos e hormonais de casos naturais de toxemia da prenhez em ovelhas

Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season

Metabolic and endocrine characteristics of pregnancy toxemia in the ferret

Contact Info

Product

Resources

About