Metabolic and endocrine characteristics of pregnancy toxemia in the ferret

Prohaczik, A.; Kulcsár, Margit; Huszenicza, G.

doi:10.17221/19/2009-vetmed

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…Insulin, T 4 , and T 3 are important hormones in the regulation of energy homeostasis. The decreases in T 4 in experimental pregnancy toxemic goats in the present study were similar to that recorded in ewes [ 5 ] and ferret [ 31 ] with pregnancy toxemia.…”

Section: Discussionsupporting

confidence: 90%

Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats

Hefnawy

Youssef

Shousha

2010

Veterinary Medicine International

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Pregnancy toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late pregnancy to investigate the effect of pregnancy toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of glucose and β-Hydroxybutyrate. Plasma samples were collected at 0, 12, 24, 36, 48, and 72 hours after induction of pregnancy toxemia. The result revealed that experimental animals developed neurological findings with convulsions and acetone odor from the mouth with recumbency after 72 hours. Laboratory findings showed a significant increase in β-Hydroxybutyrate, cortisol, and insulin while there were significant decreases in glucose, thyroid, and immunoglobulins (IgA, IgM, and IgG). Plasma glucose concentrations had significant negative correlations with β-hydroxybutyrate, cortisol, and insulin while the correlations were significantly positive with immunoglobulins and thyroid hormone. Plasma β-hydroxybutyrate concentration was significantly positively correlated with cortisol and negatively correlated with immunoglobulins, insulin, and thyroid hormone. From this study we can conclude that pregnancy toxemia might affect humoral immune responses as well as insulin, cortisol, and thyroid hormones. Moreover, insulin might have a compensatory role to increase suppressive effect on ketogenesis in experimentally pregnant toxemic goats.

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Section: Discussionsupporting

confidence: 90%

Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats

Hefnawy

Youssef

Shousha

2010

Veterinary Medicine International

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“…Insulin, T4, and T3 are important hormones in the regulation of energy homeostasis. The decreases in T4 in pregnancy toxemic ewes in the present study were similar to that noticed in ewes (Kulcs´ar et al, 2006) Goats (Hefnawy et al, 2011) and ferret (Prohaczik et al, 2009) with pregnancy toxemia. And the significance decreases in T3 is disagreed with (Hefnawy et al, 2011).…”

Section: Discussionsupporting

confidence: 89%

Clinico-Biochemical Diagnosis of Pregnancy Toxemia in Ewes with Special Reference to Novel Biomarkers

Elshahawy¹

2016

AJVS

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Fifty five ewes aged from 3-5 years were included in this study; these animals were selected fro m sheep reared in d ifferent villages in Menofia and Behera governorates, Egypt. All an imals were subjected to careful clinical and laboratory investigations. Accordingly, the selected animals were divided into three groups. Group (A) consisted of 20 ewes showed signs of pregnancy toxemia. Group (B) consisted of 20 heavily pregnant ewes in two or more fetuses determined by ultrasonography. Group (C) consisted of 15 non pregnant ewes. Clinical examination of ewes with pregnancy toxemia reveals anorexia, loss of condition, nervous movement of the eye which is bulging and roaring, grinding of the teeth, champ ing of the jaw with salivation, spasms in the neck and back muscles and lateral recu mbency, odor of acetone in the breath , drowsiness and stiffness of the body. Biochemical findings reveals significance decrease of glucose, cholesterol, total protein, albumin, globulin, T3, T4, calciu m, sodium and potassium in group A (p regnancy toxemia) when compared to groups B (heavily pregnant)& C (non-pregnant), also significance increase of triglyceride, non-esterified fatty acids (NEFA), β-Hydro xybutyrate, cortisol, AST, A LT, GGT LDH, urea and creatin ine when compared to groups B & C ewes. Further, ewes displaying symptoms of pregnancy toxemia (group A) had a significance increase in seru m haptoglobin (Hp), amy loid A and C-reactive protein markers compared to heavily pregnant and non-pregnant ewes.

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“…In the present study, the serum urea and creatinine levels showed significant increase in pregnancy toxemic goats, which might be attributed due to involvement of the kidney in the pathogenesis of caprine pregnancy toxemia (El-Sebaie, 1995, Hefnawy et al, 2011Marteniuk and Herdt, 1998;Nagamani et al, 1996;Ramin et al, 2005). The significant decrease in the serum levels of sodium, Akraiem et al 163 potassium and calcium as well as significant increase in the packed cell volume (PCV) in the pregnancy toxemic goats indicated that there were disturbances in the electrolytes and some minerals which may be attributed to stress of starvation, dehydration and involvement of the kidney in the pathogenesis of caprine pregnancy toxemia (Marteniuk and Herdt, 1988;Hefnawy et al, 2011;Prohaczik et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical, hematological and biochemical parameters in goats with subclinical and clinical pregnancy toxemia in Libya

Elghany¹,

Arhaiem²,

Zaid³

2020

J. Anim. Sci. Vet. Med.

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This study was aimed to evaluate the clinical, hematological and biochemical parameters in goats with clinical and subclinical pregnancy toxemia. A total of 63 pregnant goats were included in this study. On the basis of clinical examination and assessment of β-hydroxy butyric acid concentration (BHBA) does were classified into three groups. group A: Consist of 20 healthy pregnant goats, used as control. Group B: consist of 28 does with subclinical pregnancy toxemia (SCPT). Group C: consist of 15 does with clinical pregnancy toxemia (CPT). For each case, history, age, breed, number of fetus, results of clinical examination and hematobiochemical findings were recorded and analyzed. Clinical examination in clinical pregnancy toxemic goats revealed anorexia, depression, dullness, dyspnea, weakness, dropped head, lateral recumbency, acetone smell from the mouth, grinding of teeth and neurologic signs. Hemato biochemical analysis revealed a significant increase of PCV%, BHBA, ALT, AST, urea and creatinine in clinical pregnancy toxemic goats, while there was significant decrease of serum glucose, total protein, albumin, globulin, sodium, potassium and calcium. Does with subclinical pregnancy toxemia showed significantly lower serum glucose, total protein and calcium, whereas a marked increase in PCV%, urea and BHBA. The results revealed that the caprine pregnancy toxemia have severe impacts on several clinical and biochemical parameters. In order to prevent the economic loss due to pregnancy toxemia, measuring blood metabolites can be potentially useful tool for routine monitoring of subclinical pregnancy toxemia in late pregnant goats.

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Metabolic and endocrine characteristics of pregnancy toxemia in the ferret

Cited by 8 publications

References 18 publications

Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats

Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats

Clinico-Biochemical Diagnosis of Pregnancy Toxemia in Ewes with Special Reference to Novel Biomarkers

Evaluation of clinical, hematological and biochemical parameters in goats with subclinical and clinical pregnancy toxemia in Libya

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