Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis

Hensel, Katherine J.; Randis, Tara M.; Gelber, Shari E.; Ratner, Adam J.

doi:10.1016/j.ajog.2010.08.013

Cited by 113 publications

(106 citation statements)

References 31 publications

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“…Vitamin D plays a role in modulation of both. The study by Hansel et al [11] demonstrated an association between bacterial vaginosis in the case of pregnant women and deficiency of vitamin D. That study demonstrated that the vitamin D level below 30 ng/ml increased the risk of bacterial vaginosis (BV) 2.87 times, and that was supported by some earlier reports [11]. The study by Bodnar et al [12] indicated that vitamin D deficiency significantly reduced the risk of BV in the group of black pregnant women, but no association was confirmed in the group of white pregnant women.…”

Section: Vitamin D Level and Preterm Birth Rate O R I G I N A L P A Pmentioning

confidence: 99%

Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland

Baczyńska-Strzecha

Kalinka

2017

Int J Occup Med Environ Health

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Objectives: Aim of this project is determination of the correlation between the level of vitamin D in blood serum and duration of pregnancy in population in central Poland. Material and Methods: 25-Hydroxyvitamin D (25(OH)D) level was determined in blood serum, using enzyme-linked immunosorbent assay (ELISA). Standardized history of each patient was recorded. The history included: general medical history, data regarding the course of pregnancy and information about health-related behavior that could influence vitamin D concentration. Two hundred-and-one Caucasian women at childbirth were qualified into the study. The study group was divided into 2 parts: 100 patients who had a spontaneous premature birth and 101 patients who had birth at full term. Results: Vitamin D deficiency (< 30 ng/ml) was very common for both groups (69.6% of patients in the premature group and 72% -in the control group). Patients who had a premature birth had severe vitamin D deficiency (less than 10 ng/ml) more often than in the control group (34% vs. 14.2%, p = 0.001). Severe vitamin D deficiency increased the risk of premature birth but the association was not statistically significant in the multivariate regression model (odds ratio (OR) = 2.47, 95% confidence interval (CI): 0.86-7.15, p = 0.094). Conclusions: Severe vitamin D deficiency (< 10 ng/ml) may be the factor increasing the risk of preterm birth. Int J Occup Med Environ Health 2017;30(6):933 -941

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Section: Vitamin D Level and Preterm Birth Rate O R I G I N A L P A Pmentioning

confidence: 99%

Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland

Baczyńska-Strzecha

Kalinka

2017

Int J Occup Med Environ Health

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“…Recent studies suggest that vitamin D aids in the process of implantation, maintains normal pregnancy, supports fetal growth through delivery of calcium, controls secretion of multiple placental hormones and limits the production of proinflammatory cytokines [1]. Maternal risk of pre-eclampsia, gestation diabetes and infectious diseases has been related with low levels of maternal circulating 25(OH)D in a number of observational studies [2][3][4]. Few reports indicating an effect of vitamin D or vitamin D receptor polymorphisms on the duration of pregnancy have been published so far [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Baczyńska-Strzecha

Kalinka

2016

Ginekol Pol

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Objectives: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy.The aim of this study was to evaluate the association between the parturients' Apa1, Taq1, and Bsm1 polymorphisms of the VDR and their combinations and the risk of preterm birth in the Polish population. Material and methods:Determination of polymorphism for VDR was assayed using the RT-PCR method. 199 Caucasian women at childbirth were qualified:100 patients who had a spontaneous preterm birth and 99 patients who had a term birth.Results: Three separate genotypes of the Apa1, Taq1, and Bsm1 polymorphisms were detected. No significant differences in the frequency of particular genotypes in the compared groups were found. Some of the genotype combinations were significantly more frequent in the preterm group -the bb/AA/TT genotype (28.0% vs. 10.1%; p = 0.0013) and the BB/aa/tt genotype (14.0% vs. 4.04% p = 0.0277). The Bb/AA/Tt and the BB/Aa/tt genotypes were found only in the control group (16.1% and 7.0% of patients, respectively). The bb/aa/TT was significantly more frequent in the control group (2.0% vs. 11.1%; p = 0,0207). Two genotype combinations reduced the risk of preterm birth -the Bb/AA/Tt genotype by 94% (OR = 0.43, 95% CI: 0.002-0.885, p = 0.041) and the BB/Aa/tt genotype by 98% (OR = 0.029, 95% CI: 0.001-0.838, p = 0.039). Conclusions:Our result suggests that there may be a relationship between certain VDR genotype combinations and the risk of preterm birth. Further research is needed in order to substantiate this finding.

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“…Дефицит витамина D обусловливает ряд неблагоприятных осложнений беременности: гипертензию и особенно преэклампсию [24], увеличение частоты кесарева сечения и спон-танных преждевременных родов [25], снижение веса новорожденных при рождении, развитие бактериального вагиноза на ранних сроках бе-ременности [26], гестационный сахарный диа-бет [27].…”

Section: роль витамина D в регуляции репродуктивной функцииunclassified

The role of vitamin D in the pathogenesis of genital endometriosis

Denisova

Yarmolinskaya

2017

Z.akus.zen.bolezn

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The influence of vitamin D on the women’s health is undeniable. Here we review the modern classification of vitamin D forms and receptors, the current understanding of genomic and non-genomic regulation pathways of vitamin D synthesis. It was found that a vitamin D deficiency related to the development of many diseases, negative impact on reproductive function and pregnancy outcomes. Nowadays, vitamin D is concerned as a prohormone that has multiple effects. Special attention is given to the role of vitamin D in the pathogenesis of genital endometriosis. It is known that vitamin D has anti-inflammatory, antiproliferative and immunomodulating effects, which allow it to be considered as a forward-looking target therapy in endometriosis.

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Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis

Cited by 113 publications

References 31 publications

Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland

Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

The role of vitamin D in the pathogenesis of genital endometriosis

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