Pregnancy outcomes of women with and without a history of anorexia nervosa

Eagles, John M.; Lee, A J; Raja, Edwin Amalraj; Millar, Harry; Bhattacharya, Sohinee

doi:10.1017/s0033291712000414

Cited by 27 publications

(29 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Offspring weight and length are strongly heritable (Lunde, et al, 2007) yet can be modified by environmental exposures. In the current study, there was evidence that AN was associated with offspring undernutrition and BED with overnutrition, supporting prior research (Conti, et al, 1998; Eagles, et al, 2012; Linna, et al, 2014; Perrin et al, 2015). …”

Section: Discussionsupporting

confidence: 86%

“…The most compelling evidence prior to this study of a consistent negative perinatal impact of maternal eating disorders has been found for prenatal and neonatal growth outcomes (Bansil, et al, 2008; Bulik, et al, 1999; Bulik, et al, 2009; Conti, Abraham, & Taylor, 1998; Eagles, et al, 2012; Ekeus, et al, 2006; Kouba, et al, 2005; Linna, et al, 2014; Micali, et al, 2012; Micali, Simonoff, & Treasure, 2007; Pasternak, et al, 2012). Offspring weight and length are strongly heritable (Lunde, et al, 2007) yet can be modified by environmental exposures.…”

Section: Discussionmentioning

confidence: 72%

“…BED, characterized by loss-of-control overeating, is associated with gestational hypertension (Linna, et al, 2014). Eating disorders are associated with an increased risk of problems at labor and delivery, including higher risk of caesarian delivery (Bansil, et al, 2008; Bulik et al, 1999; Bulik et al, 2009; Eagles, Lee, Raja, Millar, & Bhattacharya, 2012; Ekeus, Lindberg, Lindblad, & Hjern, 2006; Micali et al, 2012; Pasternak et al, 2012), fetal distress (Micali, et al, 2012), resuscitation (Linna, et al, 2014), low Apgar scores in newborns (Linna, et al, 2014), and even perinatal death (Linna, et al, 2014). Negative outcomes for neonates, especially on nutrition- and growth-related outcomes, have been reported.…”

Section: Maternal Eating Disorders and The Associated Risks For Mothementioning

confidence: 99%

“…Negative outcomes for neonates, especially on nutrition- and growth-related outcomes, have been reported. Maternal AN, which involves extreme underweight and dietary restriction, has been associated with intrauterine growth restriction, small-for-gestational-age, and low birth weight in offspring (Bansil, et al, 2008; Eagles, et al, 2012; Pasternak, et al, 2012; Solmi, Sallis, Stahl, Treasure, & Micali, 2013), and maternal BED with large-for-gestational-age (Bulik, et al, 2009; Linna, et al, 2014). …”

Section: Maternal Eating Disorders and The Associated Risks For Mothementioning

confidence: 99%

“…Most studies have focused on the presence of eating disorders at any point in life, because of the unfeasibility of recruiting a large sample of pregnant women with active eating disorders, but associations have been demonstrated in studies of both acutely ill mothers and lifetime history studies (Linna, et al, 2014; Pasternak, et al, 2012). The reasons for the associations between lifetime eating disorders and perinatal complications are unclear, but could involve under- or over-nourishment, higher stress reactivity, residual symptoms, relapse in women at varying stages of recovery, or unmeasured third variables that influence both risk for eating disorders and perinatal complications (Eagles, et al, 2012; Franko et al, 2001; Kouba, et al, 2005). Thus, it is expected that similar perinatal complications would be observed in samples of pregnant women with an acute or lifetime history.…”

Section: Maternal Eating Disorders and The Associated Risks For Mothementioning

confidence: 99%

See 4 more Smart Citations

Maternal eating disorders and perinatal outcomes: A three-generation study in the Norwegian Mother and Child Cohort Study.

Watson¹,

Zerwas²,

Torgersen³

et al. 2017

Journal of Abnormal Psychology

View full text Add to dashboard Cite

Previous research suggests that maternal eating disorders are associated with adverse pregnancy, delivery, and neonatal outcomes. In turn, adverse perinatal outcomes have been associated with subsequent eating disorder risk in adult offspring, possibly reflecting a transgenerational cycle of risk. Previous studies of the relationship between maternal eating disorders and adverse perinatal outcomes have failed to control for familial transmission of perinatal event phenotypes, which may confound the association. In a unique design afforded by the Norwegian Mother and Child Cohort Study (MoBa) and Medical Birth Registry of Norway, we linked three generations through birth register records and maternal-reported survey data. The aim was to determine if maternal eating disorders increase risk after parsing out the contribution of familial transmission of perinatal events. The samples were 70,881 pregnancies in grandmother-mother-child triads for analyses concerning eating disorder exposure during pregnancy and 52,348 for analyses concerning lifetime maternal eating disorder exposure. As hypothesized, eating disorders predicted a higher incidence of perinatal complications even after adjusting for grandmaternal perinatal events. For example, anorexia nervosa immediately prior to pregnancy was associated with smaller birth length (relative risk = 1.62, 95% confidence interval = 1.20, 2.14), bulimia nervosa with induced labor (1.21; 1.07, 1.36), and binge-eating disorder with several delivery complications, larger birth length (1.25; 1.17, 1.34), and large-for-gestational-age (1.04; 1.01, 1.06). Maternal pregravid body mass index and gestational weight mediated most associations. Our results support the contention that exposure to eating disorders increases the risk for negative health outcomes in pregnant women and their babies.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 72%

Section: Maternal Eating Disorders and The Associated Risks For Mothementioning

confidence: 99%

Section: Maternal Eating Disorders and The Associated Risks For Mothementioning

confidence: 99%

Section: Maternal Eating Disorders and The Associated Risks For Mothementioning

confidence: 99%

See 3 more Smart Citations

Maternal eating disorders and perinatal outcomes: A three-generation study in the Norwegian Mother and Child Cohort Study.

Watson¹,

Zerwas²,

Torgersen³

et al. 2017

Journal of Abnormal Psychology

View full text Add to dashboard Cite

show abstract

Impact of eating disorders on obstetric outcomes in a large clinical sample: A comparison with the HUNT study

Eik‐Nes

Horn

Strohmaier

et al. 2018

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

Pregnancy outcomes in women with anorexia nervosa

Ante

Luu

Healy‐Profitós

et al. 2020

Intl J Eating Disorders

View full text Add to dashboard Cite

Objective: Birth outcomes of women with anorexia nervosa are poorly understood.We hypothesized that hospitalization for anorexia nervosa before or during pregnancy is associated with an elevated risk of adverse maternal and infant birth outcomes. Method:We performed a retrospective cohort study of 2,134,945 pregnancies in Quebec, Canada, from 1989 to 2016. The main exposure measure was anorexia nervosa requiring hospital treatment before or during pregnancy. Outcome measures included stillbirth, preterm birth, low birth weight, small-for-gestational age birth, preeclampsia, gestational diabetes, cesarean delivery, and other pregnancy disorders.We computed risk ratios and 95% confidence intervals (CI) for the association between anorexia nervosa and birth outcomes adjusted for maternal characteristics.Results: Compared with no hospitalization, anorexia nervosa hospitalization was associated with 1.99 times the risk of stillbirth (95% CI 1.20-3.30), 1.32 times the risk of preterm birth (95% CI 1.13-1.55), 1.69 times the risk of low birth weight (95% CI 1.44-1.99), and 1.52 times the risk of small-for-gestational age birth (95% CI 1.35-1.72). The associations with low birth weight and small-for-gestational age birth were more prominent in women hospitalized for anorexia nervosa during pregnancy or within 2 years of delivery. Hospitalization for anorexia nervosa was associated with certain maternal outcomes, including precipitate labor, acute liver failure, and admission to an intensive care unit.Discussion: Hospitalization for anorexia nervosa before or during pregnancy is associated with adverse infant and maternal outcomes. Infants are primarily at risk of stillbirth, preterm birth, low birth weight, and small-for-gestational age birth. K E Y W O R D Sanorexia nervosa, eating disorder, obstetric complications, pregnancy, retrospective study

show abstract

Pregnancy outcomes of women with and without a history of anorexia nervosa

Abstract: Mothers with a history of AN are at increased risk of adverse pregnancy outcomes. The magnitude of these risks is relatively small and should be appraised holistically by psychiatric and obstetric services.

Cited by 27 publications

References 57 publications

Maternal eating disorders and perinatal outcomes: A three-generation study in the Norwegian Mother and Child Cohort Study.

Maternal eating disorders and perinatal outcomes: A three-generation study in the Norwegian Mother and Child Cohort Study.

Impact of eating disorders on obstetric outcomes in a large clinical sample: A comparison with the HUNT study

Pregnancy outcomes in women with anorexia nervosa

Contact Info

Product

Resources

About