Pregnancy Outcomes After Assisted Human Reproduction

Okun, Nanette; Sierra, Sony; Wilson, R. Douglas; Audibert, François; Brock, Jo-Ann; Campagnolo, Carla; Carroll, June C.; Cartier, Lola; Chitayat, David; Gagnon, Alain; Johnson, Jo-Ann; Langlois, Sylvie; Murphy-Kaulbeck, Lynn; MacDonald, William; Pastuck, Melanie; Tan, Lih Yeen; Poplak, Valda; Robson, Helen

doi:10.1016/s1701-2163(15)30685-x

Cited by 121 publications

(76 citation statements)

References 154 publications

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“…There is increasing evidence that infertility or subfertility per se are independent risk factors for obstetrical complications and adverse perinatal outcomes, even without the addition of ART [285]. Unadjusted analyses suggest a 2-fold increased risk of preeclampsia in spontaneous singleton pregnancies in women with a history of infertility compared with women in the general population [286].…”

Section: Consensus Recommendationsmentioning

confidence: 99%

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Brenner

Charlton

Luyckx

et al. 2017

Nephron

119

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Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.

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Section: Consensus Recommendationsmentioning

confidence: 99%

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Brenner

Charlton

Luyckx

et al. 2017

Nephron

119

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“…Applied methods include, for instance, artificial insemination, in vitro fertilisation, and, in regard to animal species, cloning by somatic cell nuclear transfer. However, the pregnancy outcome suffers from limitations caused by the artificial treatments and in vitro culture of the germ cells and associated, altered patterns of gene expression [147][148][149][150]. This affects the health status of the newborn but also influences later periods of live.…”

Section: Laurasiatheriamentioning

confidence: 99%

“…This affects the health status of the newborn but also influences later periods of live. The following alterations may occur: obstetrical complications, preeclampsia, preterm birth, low birth weight, imprinting phenotypes, infertility, or the onset of cancer [149][150][151][152]. Recently, several studies deal with the effects of reproductive techniques in domestic cattle, because assisted reproduction is commonly applied and the bovine has a long gestation period with well-developed newborn [153,154].…”

Section: Laurasiatheriamentioning

confidence: 99%

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Mess

2014

Advances in Biology

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Here a survey of placental evolution is conducted. Placentation is a key factor for the evolution of placental mammals that had evolved an astonishing diversity. As a temporary organ that does not allow easy access, it is still not well understood. The lack of data also is a restriction for better understanding of placental development, structure, and function in the human. Animal models are essential, because experimental access to the human placenta is naturally restricted. However, there is not a single ideal model that is entirely similar to humans. It is particularly important to establish other models than the mouse, which is characterised by a short gestation period and poorly developed neonates that may provide insights only for early human pregnancy. In conclusion, current evolutionary studies have contributed essentially to providing a pool of experimental models for recent and future approaches that may also meet the requirements of a long gestation period and advanced developmental status of the newborn in the human. Suitability and limitations of taxa as alternative animal models are discussed. However, further investigations especially in wildlife taxa should be conducted in order to learn more about the full evolutionary plasticity of the placenta system.

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“…19 Further research is needed to confirm the risks to children born of IVF and to determine whether there are risks specifically associated with births from frozen eggs.…”

Section: Risks To Offspringmentioning

confidence: 99%