Pregnancy outcome after gestational exposure to amiodarone in Canada

Amiodaron i tarczyca

“…It seems prudent to advise that foetal/neonatal hypothyroidism be treated, as soon as the diagnosis is made, even in utero, to avoid neurodevelopment abnormalities, although the latter may occur independently of hypothyroidism. Twelve cases with gestational exposure to AMIO were identified in Canada: of six newborns with first-trimester exposure, one had congenital nystagmus with synchronous head titubation, there was one case of transient neonatal hypothyroidism (9%), and one of transient neonatal hyperthyroidism (9%): a fourth child, exposed to AMIO from the 20 th week of gestation, had developmental delay, hypotonia, hypertelorism, and micrognathia [107]. AMIO is excreted into human milk, so breast-feeding should not be initiated or should not be continued if the mother is treated with AMIO.…”

“…Wśród nich był też jeden przypadek przejściowej niedoczynności tarczycy noworodków (9%) oraz jeden przypadek przejściowej noworodkowej nadczynności tarczycy (9%). Czwarte dziecko, narażone na AMIO w 20. tygodniu ciąży, miało opóźnienie rozwoju, hipotonię, hiperteloryzm i mikrognatię [107]. Amiodaron przenika do mleka kobiecego.…”

Amiodarone-Induced Neonatal Hypothyroidism: A Unique Form of Transient Early-Onset Hypothyroidism

“…3 There are 69 reported cases of amiodarone use during pregnancy in which the infants' thyroid function was documented. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In all, 16 infants developed hypothyroidism 3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18] ( Table 1), and two developed hyperthyroidism. 18,19 The overall incidence of hypothyroidism was 23% (16/69).…”

“…Short-term thyroid replacement was documented in only 44% (7/16) of the infants. [9][10][11][12]16,18 Limited data are available on the long-term neuropsychological development of infants exposed to amiodarone during pregnancy, with only anecdotal data for those with amiodarone-induced hypothyroidism [9][10][11][12]17,18 ( Table 1). The largest report 20 retrospectively evaluated 10 children exposed to amiodarone in utero for 8 to 40 weeks compared to age-matched controls.…”

“…3 The effects of amiodarone during pregnancy on neonatal thyroid function have only been addressed in a limited number of reports. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] We describe two patients with transient neonatal hypothyroidism due to in utero amiodarone exposure.…”