2015
DOI: 10.5603/ep.2015.0025
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Amiodaron i tarczyca

Abstract: Amiodarone, a benzofuranic iodine-rich antiarrhythmic drug, causes thyroid dysfunction in 15-20% of cases. Amiodarone can cause both hypothyroidism (AIH, amiodarone-induced hypothyroidism) and thyrotoxicosis (AIT, amiodarone-induced thyrotoxicosis). AIH is treated by L-thyroxin replacement and does not need amiodarone discontinuation. There are two main forms of AIT: type 1, a form of true iodineinduced hyperthyroidism; and type 2, a drug-induced destructive thyroiditis. However, mixed/indefinite forms exist, … Show more

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Cited by 34 publications
(13 citation statements)
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“…2) [19,44]. In some circumstances (see above) an emergency or salvage thyroidectomy may be the initial therapeutic choice.…”
Section: What Is the Management Of Ait 1?mentioning
confidence: 99%
“…2) [19,44]. In some circumstances (see above) an emergency or salvage thyroidectomy may be the initial therapeutic choice.…”
Section: What Is the Management Of Ait 1?mentioning
confidence: 99%
“…One of the most frequent ADR-induced thyroiditis is due to Amiodarone, a common antiarrhythmic drug (Ahmed et al, 2011). In the case of Amiodarone-related thyroid disorders, the mechanisms underlying AMIO thyroid toxicity have been elusive, and no link has been found yet between genetic variants and its thyroid disorders, both hypothyroidism and thyrotoxicosis (Jabrocka-Hybel et al, 2015). Noteworthy, some patients developing thyroid-related amiodarone adverse reactions are already affected by diverse thyroid disorders.…”
Section: Drug Induced Thyroid Diseasesmentioning
confidence: 99%
“…Może wywoływać zarówno niedoczynność tarczycy (rzadziej), jak i nadczynność tarczycy (częściej). O ile niedoczynność zdarza się zwykle już w trakcie przyjmowania amiodaronu, o tyle czas wystąpienia nadczynności bywa różny; może ona bowiem objawić się nawet po kilku miesiącach od zaprzestania przyjmowania leku [17]. Środki cieniujące i amiodaron mogą wywoływać tyreotoksykozę w przebiegu destrukcyjnego zapalenia tarczycy [18].…”
Section: Leki a Podaż Joduunclassified