Pregnancy outcome after blastocyst transfer as compared to early cleavage stage embryo transfer

Schwärzler, P.

doi:10.1093/humrep/deh398

Cited by 78 publications

(82 citation statements)

References 31 publications

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“…This prolongation of culture to day 5 may allow chromosomally competent embryos to develop to the blastocyst stage, thereby promoting intact embryos [2]. We believe that extension of embryo culture to day 5 will promote better quality of embryos for transfer, additionally, less number of embryos will be transferred so as to decrease the number of high order multiple pregnancies.…”

Section: Discussionmentioning

confidence: 99%

“…Development of sequential tissue culture media attempts to give the growing embryo its metabolic and chemical needs, which has resulted in an extension of the embryo culture period to the blastocyst stage [2][3][4][5]. Therefore, the transfer of human blastocysts in IVF should result in an increased implantation rate and enable the transfer of fewer, but higher quality embryos.…”

Section: Introductionmentioning

confidence: 99%

“…According to Ronal et al [11] blastocyst transfer resulted in fewer embryos transferred, with a trend toward improving clinical pregnancy and twin pregnancy rate. The study of Peter et al [2] concluded that blastocyst transfer may lead to a higher pregnancy rate with an overall better take -home baby rate.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy outcome of day 3 versus day 5 embryo transfer: A retrospective analysis

Alfaraj

Alzaher

Alshwaiaer

et al. 2017

APJR

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pregnancy outcome of day 3 versus day 5 embryo transfer: A retrospective analysis

Alfaraj

Alzaher

Alshwaiaer

et al. 2017

APJR

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“…They either find more males born after fresh blastocyst transfer compared to spontaneous conception [19] or compared to day 3 transfer [8,17,21], or they show no differences neither in sex ratio nor in growth rate of embryos [9,23,[26][27][28][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Blastocyst transfer and gender: IVF versus ICSI

Hentemann

Briskemyr

Bertheussen

2009

J Assist Reprod Genet

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Purpose To investigate the difference in sex ratio in our centre after day 5 embryo transfer among neonates delivered after fresh in vitro fertilization (IVF), fresh intra cytoplasmatic sperminjection (ICSI) and frozen embryo replacement (FER) compared to expected sex ratio in normal population. Methods Retrospective data after IVF/ICSI/FER therapy from 1995 -2007 and data from the literature on similar subjects. Results Among a total of 420 births after day 5 transfer, there were 225 male and 195 female babies. However, after ICSI alone 30 were female and 21 male. Adding all available data from the literature on gender ratio after long term culture, the ratio of male births to total births (0.545) was significantly (p=0.004) different from the expected ratio (0.515) Conclusions It appears that significantly more males are born than expected after day 5 transfer in IVF. However, a subgroup analysis in our data comparing IVF, ICSI and FER revealed more females born after ICSI and FER, suggesting that further research is needed in this area.

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“…Blastocyst culture techniques have improved and the blastocysts can be cyropreserved by vitrification [3]. A number of investigators have reported superior clinical results with blastocyst transfer (BT) rather than transfers using cleavage-stage embryos [4][5][6]. Moreover, it has been reported that BT may be efficacious in cases of repeated pregnancy failure with cleavage stage embryo transfer [5,6].…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Yanaihara¹,

Yorimitsu²,

Motoyama³

et al. 2008

J Assist Reprod Genet

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Purpose Frozen embryo transfer has been established as an indispensable ART procedure for both the effective use of surplus embryos and the prevention of ovarian hyperstimulation syndrome. The frequency of frozen embryo transfer is increasing in our clinic, and we report that frozen embryo transfer is effective for patients with repeat failures. We present our clinical outcome of frozen blastocyst transfer (FBT). Methods In 2006, 470 patients received FBT (562 cycles (IVF: 354 cycles; ICSI: 208 cycles)). One frozen blastocyst was transferred in 412 cycles (335 patients) and two blastocysts were transferred in 150 cycles (135 patients). Assisted hatching was performed in all cases. Results In 412 cycles (average age: 34.6 years) who received a single FBT, the rate of clinical pregnancy per cycle was 40.7%, the live birth rate was 29.1%, the abortion rate was 21.6%, the ectopic pregnancy rate was 1.2%, the frequency of monochorionic twins was 2.3%, and the cesarean section rate was 38.3%. In 150 cycles (average patient age 34.8 years) who received two FBTs, the clinical pregnancy rate was 46%, the live birth rate was 35.3%, the abortion rate was 16.3%, the ectopic pregnancy rate was 4.4%, the frequency of twins was 15.9% and the cesarean section rate was 39.6%. A significant difference in the ectopic pregnancy rate and the twinning rate was found between single transfers and double transfers (P<0.05). When IVF and ICSI were compared, there was no statistically significant difference in the abortion rate, the ectopic pregnancy rate, and the cesarean section rate. Conclusions The clinical pregnancy rate was similar for the transfer of one and two blastocysts. Single FBT decreases obstetrical risk without reducing the pregnancy rate.

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Pregnancy outcome after blastocyst transfer as compared to early cleavage stage embryo transfer

Abstract: Our data suggest that blastocyst transfer may lead to a higher pregnancy rate with an overall better take-home baby rate (THBR) at the cost of higher rates of multiples and preterm deliveries.

Cited by 78 publications

References 31 publications

Pregnancy outcome of day 3 versus day 5 embryo transfer: A retrospective analysis

Pregnancy outcome of day 3 versus day 5 embryo transfer: A retrospective analysis

Blastocyst transfer and gender: IVF versus ICSI

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

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