Objective: To evaluate the effect of paternal age on in-vitro fertilization (IVF) outcomes.Design: Retrospective cohort study. Setting: Reproductive Endocrinology and Infertility Unit. Patients: The study included 451 couples undergoing their first IVF cycle. Main outcome measures: Effect of advancing paternal age on: semen parameters; IVF cyclerelated factors e.g., number of oocyte retrieved, fertilization rate, high quality embryo rate; and IVF outcome i.e., pregnancy rate.Results: The mean paternal age in our study was 36.3 years (range: 24-76 years). Approximately half of the study couples (51.9%) had secondary infertility with anovulation being the major cause. We found no significant correlations between the advancing paternal age and the semen parameters -sperm volume (p = 0.28), sperm concentration (p = 0.47), or sperm motility (p = 0.91). IVF cycle-related factors did not significantly differ for advancing paternal age groups -number of oocyte retrieved (p = 0.52), number of embryos fertilized (p = 0.14), fertilization rate (p = 0.94), or the high quality embryo rate (p = 0.84). Likewise, we found no significant association between the advancing paternal age and the positive IVF outcome i.e., the positive serum pregnancy test (p = 0.64).Conclusion: Advancing paternal age does not affect the IVF outcomes in a Saudi population.Ó 2014 Production and hosting by Elsevier B.V. on behalf of Middle East Fertility Society.
Objectives:To compare follicular reduction prior to human chorionic gonadotropin (HCG) trigger and coasting in terms of ovarian hyper-stimulation syndrome (OHSS) reduction, pregnancy, and cancellation rates in in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles.Methods:This study was designed as a prospective study. The setting was the IVF unit at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. A total of 39 patients undergoing IVF/ICSI cycles, who were at risk of OHSS, 20 were put into a coasting group and 19 had follicular reduction instead. This occurred between October 2010 and January 2011. Our main outcome was OHSS reduction.Results:Six (30%) women developed OHSS in the coasting group and 2 (10.5%) women developed OHSS in the follicular group (p-value=0.235). The pregnancy rates in the cycles were similar for both groups: 4/20 (20%) in the coasting group and 3/19 (15.8%) in the follicular group (p-value=1.000). The cancellation rate of the cycles was similar for both groups, 6/20 (30%) in the coasting group and 1/19 (5.3%) in the follicular group (p-value=0.09). The median number of punctured follicles was significantly lower in the follicular group (16 follicles, interquartile range (IQR)=21-12) compared to the coasting group (29 follicles, IQR=37.8-19.8, p-value=0.001). The retrieved, fertilized, and cleaved oocytes, as well as the number of embryos transferred, were similar amongst both groups.Conclusion:There was no difference between follicular reduction prior to HCG and coasting, in terms of OHSS reduction, pregnancy, and cancellation rates in both the IVF and ICSI cycles.
Aim:
To investigate the knowledge of Saudi women regarding the teratogenic effects of environmental agents such as fever, some chronic conditions and medications and its association with certain socio-demographic factors.
Materials and Methods:
A survey based cross-sectional study was conducted on 315 Saudi women of childbearing age visiting OB/GYN clinics at a large tertiary care centre in Riyadh, Saudi Arabia. Knowledge of subjects on teratogenic risk of common entities was measured and nonparametric Mann–Whitney and Kruskal–Wallis tests were used to associate knowledge score with various predictors.
Results:
The response rate was 75%. Most of the participants were between 28 and 37 years. Knowledge on teratogenic risk was generally poor with specifically higher knowledge regarding insulin intake and isotretinoin. Older age, higher education, being employed, and having a high monthly income were significantly associated with a higher knowledge score (
P
< 0.05).
Conclusion:
Women's knowledge regarding teratogenic risks is crucial in ensuring a safe pregnancy and a healthy fetus. Our study revealed inadequate knowledge of teratogens among the participants which implies an urgent need to increase awareness of mothers regarding the harmful effects of common teratogens.
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