Pregnancy in women with complete transposition of the great arteries following the atrial switch procedure. A study from three of the largest Adult Congenital Heart Disease centers in Poland

Lipczyńska, Magdalena; Szymański, Piotr; Trojnarska, Olga; Tomkiewicz‐Pająk, Lidia; Pietrzak, Bronisława; Klisiewicz, Anna; Kumor, Magdalena; Podolec, Piotr; Hoffmań, Piotr

doi:10.1080/14767058.2016.1177821

Cited by 8 publications

(24 citation statements)

References 14 publications

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“…Congenital heart disease is one of the most common types of fetal deformity and may be caused by a variety of pathological factors, including a change in chromosomal structure or a gene mutation [26, 27]. Diagnosing congenital heart disease is an important part of prenatal screening [28, 29].…”

Section: Discussionmentioning

confidence: 99%

Use of magnetic resonance imaging combined with gene analysis for the diagnosis of fetal congenital heart disease

Wang¹,

Nie

Wang³

et al. 2019

BMC Med Imaging

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BackgroundFetal deformity is a disease caused by abnormal chromosome structure, which may be influenced by genetic factors as well as the maternal and external environment. Magnetic resonance imaging (MRI) may be used to effectively diagnose fetus deformities. However it has been reported that gene analysis is a more accurate diagnostic method. The aim of the present study was to investigate the effectiveness of MRI in combination with gene analysis for the diagnosis of fetal congenital heart disease, a form of fetus deformity.MethodsMRI, array comparative genome hybridization analysis and fluorescence in situ hybridization were used to analyze the effectiveness of the two methods in a total of 78 pregnant women with suspected fetal congenital heart disease.ResultsOur findings demonstrated that the combination of MRI and gene analysis resulted in significantly improved diagnostic accuracy, sensitivity and specificity for fetal congenital heart disease compared with either method alone. MRI combined with gene analysis confirmed 42 fetuses with pulmonary stenosis, 24 with aortic stenosis and 12 healthy fetuses, which was significantly improved compared with MRI or gene analysis alone. It was also observed that gene analysis was a more efficient method of diagnosis compared with MRI; however, the combination of the two methods was the most effective.ConclusionIn conclusion, the results of the present study suggest that MRI combined with gene analysis may be a more effective diagnostic method for fetal congenital heart disease compared with the current protocol.

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Section: Discussionmentioning

confidence: 99%

Use of magnetic resonance imaging combined with gene analysis for the diagnosis of fetal congenital heart disease

Wang¹,

Nie

Wang³

et al. 2019

BMC Med Imaging

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“…Some cases of the atrial switch group had not recovered from systemic ventricular dysfunction at the mid-term follow-up after delivery. Moreover, six women in seven reports of the atrial switch group showed more severe cardiac complications, such as maternal death or CPA during pregnancy and at the mid-term follow-up after delivery, while no maternal death has been reported among arterial case [2][3][4]13].…”

Section: Literature Reviews For Pregnancy and Mid-term Outcomes In Womentioning

confidence: 97%

“…The eight articles were classified as describing pregnancy outcomes after atrial switch operation (seven reports) and outcomes after ASO (one report) ( Fig. 1) [2][3][4]13,[15][16][17][18]. A total of 8 articles and this study were reviewed.…”

Section: Literature Reviews For Pregnancy and Mid-term Outcomes In Womentioning

confidence: 99%

“…However, the past studies have described that these patients were at high risk of systemic right ventricular dysfunction, atrial arrhythmias, and cardiac death at long-term follow-up [1]. Pregnancy with d-TGA after atrial switch operation resulted in severe cardiac complications such as maternal death or cardiopulmonary arrest (CPA) during pregnancy and by mid-term follow-up after delivery [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy outcomes and mid-term prognosis in women after arterial switch operation for dextro-transposition of the great arteries – Tertiary hospital experiences and review of literature

Horiuchi

Kamiya

Ohuchi

et al. 2019

Journal of Cardiology

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Arterial switch operation (ASO) for dextro-transposition of the great arteries (d-TGA) has gradually replaced the atrial switch operation and has become the standard operation. To date, the outcomes of pregnant women with d-TGA after this new operation have not been investigated. In this study, we investigated the impact of ASO on pregnant outcomes and mid-term prognosis in women with d-TGA and compared with the atrial switch operation through the literature review. Methods and results: There were 20 pregnancies in 10 women with d-TGA after ASO and 6 resulted in abortion. Among 14 successful pregnancies in 10 women, 11 pregnancies achieved the term delivery and 3 pregnancies, including 1 twin pregnancy, resulted in preterm labor. Maternal cardiovascular events occurred in 4 (heart failure and arrhythmias in 3 and arrhythmia in 1), and all were controllable with medications. Risk factors for the peripartum cardiac events were older age at ASO and delivery, and higher concentration of brain natriuretic peptide (BNP) at first trimester (p < 0.05). In 7-60 monthfollow-up after delivery, no case showed deterioration of functional class and systemic ventricular function. According to the literature review, women after ASO demonstrated a better prognosis than those after the atrial switch operation. Conclusions: The majorityof womenwith d-TGA afterASO tolerated pregnancyand delivery well. The olderage at ASO, an elderly pregnancy, and higher BNP levels at the first trimester were possibly risk factors of peripartum cardiovascular events among the group. The literature reviews and this study may indicate the advantage of systemic left ventricle compared with systemic right ventricle in long-term outcomes after delivery.

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“…The hospital stay was significantly longer in patients with cardiovascular events (median [Q1-Q3]: 4 [2][3][4][5][6] days vs 3 [2][3][4][5] days in patients without cardiovascular events, P = 0.001).…”

Section: Pregnancy Related Cardiovascular Events During Non-elective Hospitalizationsmentioning

confidence: 99%

Pregnancy-related cardiac non-elective hospitalizations and pregnancy outcomes. A tertiary referral cardiac center experience

Lipczyńska¹,

Janisz²,

Szymański³

et al. 2021

Kardiol Pol

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Pregnancy in women with complete transposition of the great arteries following the atrial switch procedure. A study from three of the largest Adult Congenital Heart Disease centers in Poland

Abstract: In our study, we demonstrated a large number of obstetric complications and low birth weight in the presence of a systemic right ventricle. However, from a cardiologist's point of view pregnancy after the M/S operation was well-tolerated and relatively safe.

Cited by 8 publications

References 14 publications

Use of magnetic resonance imaging combined with gene analysis for the diagnosis of fetal congenital heart disease

Use of magnetic resonance imaging combined with gene analysis for the diagnosis of fetal congenital heart disease

Pregnancy outcomes and mid-term prognosis in women after arterial switch operation for dextro-transposition of the great arteries – Tertiary hospital experiences and review of literature

Pregnancy-related cardiac non-elective hospitalizations and pregnancy outcomes. A tertiary referral cardiac center experience

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