Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129 290 births

Smith, Gordon C. S.; Pell, Jill P.; Walsh, David

doi:10.1016/s0140-6736(00)05112-6

Cited by 863 publications

(588 citation statements)

References 24 publications

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“…There is a well‐established association between preeclampsia, alone or in combination with SGA infants and/or preterm delivery, and subsequent risk of maternal CVD 1, 2, 3, 5, 19, 20, 21, 22, 23. In a study from 2016, we showed a doubled risk of CVD when preeclampsia occurred alone and a 4‐fold risk when preeclampsia occurred in combination with SGA and/or preterm delivery 2.…”

Section: Introductionmentioning

confidence: 69%

Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women

Riise

Sulo

Tell

et al. 2018

JAHA

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BackgroundPreeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for GH has not been established. We aimed to determine the association between GH and subsequent CVD, and explore the additional role of small‐for‐gestational‐age infants, preterm delivery, and parity.Methods and ResultsData from the Medical Birth Registry of Norway were linked to the Cardiovascular Disease in Norway project and the Norwegian Cause of Death Registry. Hazard ratios and 95% confidence intervals were computed using Cox proportional hazard regression, comparing women with and without GH during their first and/or second pregnancy. We included all women with a first delivery from 1980 through 2009 (n=617 589) and followed them for a median of 14.3 (quartile 1–quartile 3: 6.9–21.5) years. Women with GH in the first pregnancy had 1.8‐fold (95% confidence interval, 1.7–2.0) higher risk of subsequent CVD compared with women without any hypertensive pregnancy disorder. When GH occurred in combination with small‐for‐gestational‐age infants and/or preterm delivery, the hazard ratio was 2.6 (95% confidence interval, 2.3–3.0). When women with GH were compared with women with preeclampsia, the risk of CVD was comparable when the pregnancy complications occurred in either the first or second pregnancy but was significantly higher for preeclampsia without complications when the disorder occurred in both pregnancies.Conclusions GH was associated with increased risk of subsequent CVD, and the highest risk was observed when GH was combined with small‐for‐gestational‐age infants and/or preterm delivery.

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Section: Introductionmentioning

confidence: 69%

Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women

Riise

Sulo

Tell

et al. 2018

JAHA

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“…Some women experienced a complication during pregnancy such as gestational diabetes and preeclampsia which may increase their risk of CVD later in life 2, 32. We did not adjust for a history of complications of pregnancy since these events may be on the causal pathway between miscarriage and CVD 33.…”

Section: Discussionmentioning

confidence: 99%

Increased cardiovascular disease risk in women with a history of recurrent miscarriage

Wagner

Beshay

Rooijakkers

et al. 2018

Acta Obstet Gynecol Scand

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IntroductionCardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease.Material and methodsWomen who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow‐up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and no miscarriage, matched by zip code, age, and date of pregnancy. All women were invited for risk factor screening, including physical examination and blood collection. Main outcome measures were the (extrapolated) 10‐ and 30‐year cardiovascular risk scores using the Framingham risk score. A subanalysis was performed for women with idiopathic recurrent miscarriage.ResultsThirty‐six women were included in both groups. Mean follow up was 7.5 years. Women with recurrent miscarriage had a significantly higher extrapolated 10‐year cardiovascular risk score (mean 6.24%, SD 5.44) compared with women with no miscarriage (mean 3.56%, SD 1.82, P = .007) and a significantly higher 30‐year cardiovascular risk score (mean 9.86%, SD 9.10) compared with women with no miscarriage (mean 6.39%, SD 4.20, P = .04). Similar results were found in women with idiopathic recurrent miscarriage (n = 28).ConclusionsWomen with a history of recurrent miscarriage differ in cardiovascular risk profile at a young age compared with women with no miscarriage. The findings support an opportunity to identify women at risk of cardiovascular disease later in life and a possible moment for intervention.

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“…62, 63, 64, 65 In a recent JAHA article by Riise et al, the HR for risk of CVD associated with GH plus small‐for‐gestational‐age and/or preterm delivery was 2.6, compared with 1.8 for GH alone, 1.1 for small for gestational age alone, and 1.3 for preterm delivery alone 52. In terms of midterm risk, the study by Egeland et al in a recent issue of JAHA demonstrated that over median follow‐up of 7.1 years, the combination of preeclampsia and GH with a very preterm delivery (<32 weeks gestation) was associated with a markedly elevated risk of CVD that is 12.7‐fold higher than normotensive term pregnancies 58.…”

Section: Additional Impact Of Other Pregnancy‐related Complications Omentioning

confidence: 99%

Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk

Ying

Catov

Ouyang

2018

JAHA

181

119

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Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129 290 births

Cited by 863 publications

References 24 publications

Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women

Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women

Increased cardiovascular disease risk in women with a history of recurrent miscarriage

Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk

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