Pregnancy-associated transient osteoporosis of the hip: results of a case-control study

Hadji, Peyman; Boekhoff, Jelena; Hahn, M.; Hellmeyer, L; Hars, O; Kyvernitakis, I

doi:10.1007/s11657-017-0310-y

Cited by 40 publications

(40 citation statements)

References 23 publications

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“…Although quite rare, pregnancy-associated osteoporosis plays an important role for BME differential diagnosis. Pregnant women may develop BME ("pregnancy-associated transient osteoporosis of the hip") in the third trimester or immediately postpartum, especially in the pelvic bone [86]. Pregnancy-associated osteoporosis is a severe disease, typically occurring during the first pregnancy, sometimes accompanied by multiple fractures [87].…”

Section: Metabolic Bmementioning

confidence: 99%

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

Baumbach

Pfahler

Pozza

et al. 2020

JCM

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Bone marrow edema (BME) is a descriptive term for a common finding in magnetic resonance imaging (MRI). Although pain is the major symptom, BME differs in terms of its causal mechanisms, underlying disease, as well as treatment and prognosis. This complexity together with the lack of evidence-based guidelines, frequently makes the identification of underlying conditions and its management a major challenge. Unnecessary multiple consultations and delays in diagnosis as well as therapy indicate a need for interdisciplinary clinical recommendations. Therefore, an interdisciplinary task force was set up within our large osteology center consisting of specialists from internal medicine, endocrinology/diabetology, hematology/oncology, orthopedics, pediatrics, physical medicine, radiology, rheumatology, and trauma surgery to develop a consenus paper. After review of literature, review of practical experiences (expert opinion), and determination of consensus findings, an overview and an algorithm were developed with concise summaries of relevant aspects of the respective underlying disease including diagnostic measures, clinical features, differential diagnosis and treatment of BME. Together, our single-center consensus review on the management of BME may help improve the quality of care for these patients.

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Section: Metabolic Bmementioning

confidence: 99%

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

Baumbach

Pfahler

Pozza

et al. 2020

JCM

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“…The review we carried out seems to support the notion that TPBMES is most probably a single disease, whether it affects the hips (TOH) in middle aged males [1], or in younger females in their last trimester of pregnancy [20,21]. It may remain the same condition, with mild variations, if it involves the knee (TOK) [9] or the foot-and-ankle [2,6,15,22].…”

Section: Discussionmentioning

confidence: 60%

Transient Primary Bone Marrow Edema Syndrome - A Synthesis

Ohana¹

2019

AJIM

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A complex and often confusing nomenclature is currently used for relatively rare syndromes characterized by sudden onset of joint pain in the lower limbs, absence of trauma, bone marrow edema and its resolution, both confirmed by the MRI, as well as a self-limiting course. These include transient osteoporosis of the hip (TOH), of the knee (TOK), of the foot and ankle and transient bone marrow edema syndrome. Our purpose was to review the literature in order to substantiate the hypothesis that these apparently different conditions may be synthesized into a single disease entity, termed transient primary bone marrow edema syndrome (TPBMES). Of a total of 546 patients scrutinized, 342 had TOH, 105 had TOH of pregnancy, and 49, mainly females, showed transient foot-and-ankle osteoporosis. TPBMES occurred also with systemic osteoporosis or in a migratory pattern. The six proposed subsets of TPBMES have in common a MRI-based diagnosis and remission, as well as a self-limiting course. Thus, the hypothesis of a single disease entity is sustainable. We conclude that the education of the medical profession regarding this rare disease should expand. The causes of the prolonged symptoms seen in the systemic osteoporosis and migratory subsets warrant further studies. The efficiency of our suggested modality of management should be validated in a large cohort.

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“…When amniotic fluid is given along with OXT, it may augment the action of OXT [ 4 ]. In the combined action of amniotic fluid and OXT in augmentation of labor, it is difficult to evaluate the action of different regimens of OXT [ 29 ]. In respect to the choice of the single OXT regimen in AL, the finding was clear about confounding effects on outcome measures.…”

Section: Discussionmentioning

confidence: 99%

Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

Liu

Yang

2018

Med Sci Monit

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BackgroundThe current guideline for oxytocin regimens in the abnormal labor of delivery is continuous infusion. The objective of the present study was to compare effects and safety measures of various available regimens of oxytocin in abnormal labor delivery.Material/MethodsIn this clinical experimental study, a total of 900 pregnant women admitted for delivery were randomized into 5 group with 162 each. Pregnant women received oxytocin as continuous administration of 16 mU/min (Group I), 1 mU/min (group II), 4 mU/min (group III), 5 mU/min quarter-hourly (group IV), and through a syringe pump (group V). Measurement of the expense of delivery, the ratio of the instrumental delivery, and the other secondary outcome measures was performed to find the best regimen of oxytocin. The 2-tailed paired t test and Mann-Whitney U test following Dunnett’s multiple comparison tests were used at 95% confidence level.ResultsPulsatile delivery had least risk of instrumental delivery as compared to continuous infusion (p<0.0001, q=6.663) and normal-frequency low-dose (p<0.0001, q=5.638) of oxytocin. The time required from infusion to delivery was longer for group II (p=0.001, q=2.925), group IV (p<0.0001, q=4.829), and group V (p<0.0001, q=41.456) than for group I. The expense of delivery was: group I < group II < group IV < group III < group V.ConclusionsHigh-dose and pulsatile preparation of oxytocin had reduced risks of operative delivery vs. continuous administration.

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Pregnancy-associated transient osteoporosis of the hip: results of a case-control study

Abstract: Our results support the hypothesis that pregnancy-associated TOH is a multifactorial disease, to which several individual factors may contribute. Hereby, we found significant associations with immobility, dental problems, and lack of exercise in childhood.

Cited by 40 publications

References 23 publications

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

Transient Primary Bone Marrow Edema Syndrome - A Synthesis

Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

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