Pregnancy-associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels

Effect of pregnancy-associated plasma protein-A (PAPP-A) single-nucleotide polymorphisms on the level and activity of PAPP-A and the hormone profile in fluid from normal human small antral follicles

“…Assays of PAPP-A activity were performed to investigate whether the genetic change in PAPP-A had an effect on the proteolytic action of PAPP-A in human antral follicles. A strong positive correlation was found between the PAPP-A level and PAPP-A activity in FF toward radiolabeled IGFBP-4 cleavage, which supports earlier studies indicating that the proteolytic activity of PAPP-A is highly important for IGFBP-4 cleavage in human antral follicles and the subsequent release of local IGFs (7,37).…”

“…Proteolytic activity of PAPP-A, and hence release of IGFs, is known to be important to promote estradiol production in the growing follicle (9). A study has shown a strong positive correlation between PAPP-A levels and intrafollicular levels of estradiol and progesterone throughout folliculogenesis (37). These previous findings suggest that PAPP-A mirrors the enhancing effect of IGF signaling on ovarian follicular steroidogenesis.…”

Morphometric characteristics of preantral and antral follicles and expression of factors involved in folliculogenesis in ovaries of adult baboons (Papio anubis)

“…Such an increase in estradiol concentrations leads to suppression of FSH secretion, which in turn has a negative impact on the survival of less mature follicles [44][45][46]. In humans, Bøtkjaer et al [47] observed that while small antral follicles (5-6 mm) showed weak or absent aromatase expression in theca and granulosa cells, their larger counterparts (8-9 mm) and preovulatory follicles exhibited strong aromatase staining in granulosa cells. The follicle sizes studied by Bøtkjaer et al [47] correspond to initial cyclic recruitment of early antral follicles and selection of dominant follicles [48], confirming the increase in aromatase activity in final follicle selection.…”

Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation

“…The presence of granulosa cell or oocyte specific proteins (20,23) were detected by IHC in three TS ovaries (subjects 1, 6 and 12) and one age-matched control (Supp. Fig.…”