Pregnancy associated nasopharyngeal carcinoma: A retrospective case-control analysis of maternal survival outcomes

Cheng, Yi; Zhang, Fan; TANG, Ling; Chen, Lei; Zhou, Guan Qun; Zeng, Mu Sheng; Kang, Tie Bang; Jia, Wei Hua; Shao, Jian Yong; Qiang, Hai; Guo, Ying; Ma, Jingfei

doi:10.1016/j.radonc.2015.06.008

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…In a series of 811 patients with nasopharyngeal cancer, 33 9 women became pregnant during treatment. 34 Similar results were reported. The other eight patients died during their first year of treatment.…”

Section: Diagnosis and Prognosissupporting

confidence: 82%

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Head and neck cancer during pregnancy

Guévelou

Lebars²,

Kammerer

et al. 2019

Head & Neck

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Background The incidence of cancer during pregnancy is low but is slightly increasing. Data on incidence and etiology of head and neck (HN) cancers in pregnant women are rare. We evaluated the frequency, tumor type, associated factors, and specific biomarkers in HN cancers occurring in pregnant (and peripartum) women. Methods A systematic literature search was performed on PubMed, for any HN tumor site occurring in pregnant women. Results Sixty cases of HN cancers occurring during pregnancy were identified. Most of them were oral cavity cancers. Relationships with oncogenic viruses, hormonal disturbance, and shift in maternal immunity profile were identified. Conclusion Carcinogenesis of HN cancers in pregnant women may be led by different cancer type–specific hallmarks. Relevance of these etiological factors with respect to treatments and birth control recommendations is being investigated by the REFCOR in an ambispective study.

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Section: Diagnosis and Prognosissupporting

confidence: 82%

“…Pregnancy was not a poor prognosis factor in multivariate analysis. 34 Similar results were reported. 35 in another case-control study of 102 patients.…”

Section: Diagnosis and Prognosissupporting

confidence: 82%

Head and neck cancer during pregnancy

Guévelou

Lebars²,

Kammerer

et al. 2019

Head & Neck

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“…No previous matched cohort analysis had shown convincing evidence regarding the role of the time interval. In a recently published study by Chen et al [4], case-control analysis was used and similar survival outcomes were obtained except the loco-regional relapse-free survival (LRRFS). Their results demonstrated that the 5-year survival rates of OS, DMFS, LRRFS and disease-free survival (DFS) between the pregnancy-associated nasopharyngeal carcinoma (PANPC) were not significantly different.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, under the stimulus of pregnancy, NPC disease is particularly aggressive with advanced stage or distant metastasis, and treatment with concomitant chemoradiotherapy has been deemed pointless and unsatisfactory; thus, the survival outcome is poorer among pregnant patients than among non-pregnant patients. Unfortunately, studies about NPC patients during pregnancy are lacking, and evidence-based management of NPC during pregnancy has not been possible because most information is based on a small number of [1–4] studies. Two case-report articles regarding NPC patients during pregnancy have been recorded.…”

Section: Introductionmentioning

confidence: 99%

Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis

Zhang

Liu

Tang³

et al. 2016

Oncotarget

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ObjectivesWe aimed to evaluate the prognosis of pregnancy-associated patients with nasopharyngeal carcinoma (NPC) in a young population.MethodsFrom June 1999 to December 2010, 51 patients aged ≤ 35 years who were diagnosed with NPC during pregnancy or within one year after delivery were admitted into the pregnancy-associated group in our institution. An additional 51 patients who were not pregnant at diagnosis were selected from 451 patients based on the matching criteria to match the pregnancy-associated female patients. The primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS) and distant-metastasis failure-free survival (DMFS) and locoregional failure-free survival (LRFS).ResultsThe advanced stage was not different between the pregnant and the non-pregnant group before matching (69.8% vs. 70.3%, P = 0.690). No difference in OS at the median follow-up time of 92 months was observed between the pregnancy-associated and the non-pregnant group (85.4% vs. 92.2%, P = 0.478); likewise, no differences were observed regarding PFS and DMFS. However, the pregnancy-associated group had worse LRFS than the non-pregnant group (84.8% vs. 95.9%, P = 0.033). When the pregnancy-associated patients were dichotomized into an early pregnancy group and a late pregnancy group, our data showed that pregnancy interval did not seem to impact the risk of death or relapse.ConclusionOur results show that patients in the pregnant group did not seem to have more advanced stage or inferior survival than that in the non-pregnant group.

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“…Recent advances in radiation technology, imaging techniques, and chemotherapy have improved survival, and there are reports of successful pregnancies [28,29]. The patient in our series was diagnosed towards the end of the 2nd trimester and received chemotherapy along with concomitant radiotherapy.…”

Section: Nasopharyngeal Carcinomamentioning

confidence: 94%

Chemotherapy during Pregnancy: Cases of Hodgkin's and Non-Hodgkin's Lymphoma, Chronic Myeloid Leukemia, Breast Cancer, Nasopharyngeal Cancer, and Choriocarcinoma

et al. 2017

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Background: The use of chemotherapeutics during pregnancy is a dilemma for both the patient and the clinician. We report here our 11 years' experience with the use of chemotherapy during pregnancy. Patients: 13 patients undergoing chemotherapy during their current pregnancy were evaluated. The medical data of 5 patients with hematologic malignancies (2 Hodgkin's, 2 non-Hodgkin's lymphoma, and 1 chronic myeloid leukemia), 6 patients with breast cancer, 1 patients with nasopharyngeal cancer, and 1 patient with choriocarcinoma were retrospectively obtained from the ‘perinatal database' of Hacettepe University for the period of January 2002 through March 2016. Results: 4 patients had a medical termination due to teratologic effects. 4 patients had a vaginal delivery, and 5 patients delivered by caesarean section. The 9 newborns who had been exposed to chemotherapeutics were free of congenital anomalies. However, 1 of them died in the early neonatal period due to multi-organ failure (nasopharyngeal cancer). During the 2-year follow-up, we encountered 1 maternal mortality, which was due to multi-organ failure in a non-Hodgkin's lymphoma patient. Conclusion: Physicians must pay attention to potential teratologic problems, and should carefully balance maternal and fetal risks. Selected chemotherapeutic agents can be given in the 2nd and 3rd trimester without any major teratogenic risk. All 9 newborns in our study were free of anomalies, although 1 of them died in the neonatal period.

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Pregnancy associated nasopharyngeal carcinoma: A retrospective case-control analysis of maternal survival outcomes

Cited by 8 publications

References 19 publications

Head and neck cancer during pregnancy

Head and neck cancer during pregnancy

Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis

Chemotherapy during Pregnancy: Cases of Hodgkin's and Non-Hodgkin's Lymphoma, Chronic Myeloid Leukemia, Breast Cancer, Nasopharyngeal Cancer, and Choriocarcinoma

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