Pregnancy and non-pregnancy related immune thrombotic thrombocytopenic purpura in women of reproductive age

Rottenstreich, Amihai; Dor, S.; Keren‐Politansky, Anat; Sarig, Galit; Nadir, Yona; Ellis, Martin; Spectre, Galia; Kirgner, Ilya; Pikovsky, Oleg; Arad, Ariela; Dann, Eldad J.; Kalish, Yosef

doi:10.1007/s11239-020-02133-4

Cited by 4 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…), что связано с максимально высокими в этих сроках гестации показателями ФВ (200-500%) и минимальными значениями активности ADAMТS-13 (50%). Причем врожденная форма ТТП (синдром Апшоу -Шульмана) зачастую впервые проявляется на фоне беременности в условиях физиологического дефицита ADAMТS-13 [11].…”

Section: ттп и беременностьunclassified

“…В отношении бессимптомного течения ТТП при остающейся низкой активности ADAMТS-13 после острого эпизода рекомендуется применение ритуксимаба профилактически 1 раз в 2 месяца вне беременности, а во время беременности -проведение профилактических ПО для предотвращения рецидива заболевания в период беременности [10,11].…”

Section: лечение ттпunclassified

See 1 more Smart Citation

Thrombotic Thrombocytopenic Purpura: Etiopathogenesis, Diagnosis and Therapy (A Review)

Зуховицкая,

Кабаева,

Цвирко

2023

Лабораторная Диагностика. Восточная Европа

View full text Add to dashboard Cite

Тромботическая тромбоцитопеническая пурпура – одна из тромботических микроангиопатий. В основе патогенеза заболевания лежат наследственный или, чаще, приобретенный дефицит плазменной металлопротеиназы ADAMТS-13, накопление гигантских мультимеров фактора Виллебранда, активация тромбоцитарного тромбообразования, блокада микроциркуляции в органах, тромбоцитопения потребления, микроангиопатическая гемолитическая анемия. Лабораторная диагностика тромботической тромбоцитопенической пурпуры наряду с оценкой клинической симптоматики, выявлением тромбоцитопении и лабораторных маркеров внутрисосудистого гемолиза неиммунного генеза базируется на обнаружении дефицита ADAMТS-13, наличия и титра его иммунного ингибитора. Терапия заболевания базируется на применении плазмообмена в сочетании с иммуносупрессивной терапией глюкокортикостероидами и ритуксимабом, а также на применении препаратов, блокирующих взаимодействие тромбоцитов с фактором Виллебранда. Thrombotic thrombocytopenic purpura is one of the thrombotic microangiopathies. The pathogenesis of the disease is based on hereditary or more often acquired deficiency of plasma metalloproteinase ADAMTS-13, accumulation of giant von Willebrand factor multimers,activationofplateletthrombusformation,blockadeofmycocirculationinorgans, consumption thrombocytopenia, microangiopathic hemolytic anemia. The diagnosis of thrombotic thrombocytopenic purpura, along with the assessment of clinical symptoms, the detection of thrombocytopenia and laboratory markers of non-immune intravascular hemolysis, is based on the detection of ADAMTS-13 deficiency, the presence and titer of its immune inhibitor. Therapy of the disease is based on the use of plasma exchange in combination with immunosuppressive therapy with glucocorticosteroids and rituximab, as well as on the use of drugs that block the interaction of platelets with von Willebrand factor.

show abstract

Section: ттп и беременностьunclassified

Section: лечение ттпunclassified

Thrombotic Thrombocytopenic Purpura: Etiopathogenesis, Diagnosis and Therapy (A Review)

Зуховицкая,

Кабаева,

Цвирко

2023

Лабораторная Диагностика. Восточная Европа

View full text Add to dashboard Cite

show abstract

Maternal and fetal outcomes of pregnancy occurring after a diagnosis of immune-mediated thrombotic thrombocytopenic purpura

et al. 2022

View full text Add to dashboard Cite

Clinical case of pregnancy complicated by thrombotic thrombocytopenic purpura

Semenova,

Sarrakhov,

Gilimkhanova

et al. 2024

Acta biomedica scientifica

View full text Add to dashboard Cite

Background. Thrombotic thrombocytopenic purpura is a rare blood disease characterized by increased thrombogenesis in the microcirculation. One of the most common triggers for the development of this disease is pregnancy. The article describes a case of pregnancy complicated by thrombotic thrombocytopenic purpura.Materials and methods. To assess the clinical case, we used a retrospective analysis of medical documentation: maternity case record, birth history, results of laboratory and instrumental research methods.Results. A 32-year-old patient was admitted to hospital at week 32 of gestation with manifestations of moderate preeclampsia, thrombocytopenia, and moderate anemia. Due to worsening of the condition, the delivery was performed by cesarean section. Subsequently, the mother’s condition did not improve: thrombocytopenia and hyperbilirubinemia progressed; the level of transaminases increased; ADAMTS13 activity was 8 %. Teleconferences were repeatedly held with experts from the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov (Moscow). Complex therapy including extracorporeal methods led to a positive result; the patient was discharged in satisfactory condition under the supervision of a hematologist and obstetrician-gynecologist.Conclusion. Thrombotic thrombocytopenic purpura treatment tactics have its own characteristics; it is necessary to diagnose this pathology in a timely manner to provide qualified medical care and to prevent maternal and perinatal losses.

show abstract

Pregnancy and non-pregnancy related immune thrombotic thrombocytopenic purpura in women of reproductive age

Cited by 4 publications

References 21 publications

Thrombotic Thrombocytopenic Purpura: Etiopathogenesis, Diagnosis and Therapy (A Review)

Thrombotic Thrombocytopenic Purpura: Etiopathogenesis, Diagnosis and Therapy (A Review)

Maternal and fetal outcomes of pregnancy occurring after a diagnosis of immune-mediated thrombotic thrombocytopenic purpura

Clinical case of pregnancy complicated by thrombotic thrombocytopenic purpura

Contact Info

Product

Resources

About