Pregnancy and Delivery in Patients with Portal Vein Cavernoma

Ducarme, Guillaume; Plessier, Aurélie; Thuillier, Claire; Ceccaldi, P F; Valla, Dominique; Luton, Dominique

doi:10.1159/000232944

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…Pregnancy in patients with portal vein cavernoma has been reported in seven cases so far. Most of the patients reported earlier had an underlying aetiology for portal vein obstruction like thalassaemia intermedia,5 congenital hepatic fibrosis,6 omphalitis,7 hepatic haemangiomas8 and protein S deficiency 9. The present case did not have any underlying disorder and she was negative for thrombophilic disorders.…”

Section: Discussionmentioning

confidence: 46%

“…In the case reported by Ducarme et al ,9 the patient had jejunal varices and caesarean section was performed because of the expected higher risk of variceal bleed during vaginal delivery. Since variceal bleed is the most common complication which accounts for increased morbidity and mortality, elective caesarean section appears to be safe in these patients.…”

Section: Discussionmentioning

confidence: 99%

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Portal vein thrombosis during pregnancy

Dasari¹,

Balusamy

2013

BMJ Case Reports

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A 22-year-old primigravida was diagnosed to have portal vein thrombosis during 20th week of gestation by ultrasound examination which was carried out to rule out congenital fetal anomalies. She had splenomegaly and thrombocytopenia. Investigations did not reveal any prothrombotic disorder. She was managed with anticoagulants which were started at 31 weeks of pregnancy. Labour was induced at 40 weeks of gestation and she delivered a healthy neonate without any complications. Anticoagulants were restarted after delivery and continued through the postpartum period and up to 6 months thereafter.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Portal vein thrombosis during pregnancy

Dasari¹,

Balusamy

2013

BMJ Case Reports

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“…Vaginal delivery with passive second stage, seems to be relatively safe and less morbid in women without digestive varices. 3 Our patient consulted late in pregnancy. Hence, anticoagulation was not started.…”

Section: Discussionmentioning

confidence: 82%

“…There are two case reports from France in 2009. 3 First patient presented with PVC with pregnancy with large jejunal varices and high anticardiolipin antibody. She was delivered by cesarean section.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Portal Vein Cavernoma with Pregnancy

Gawande¹,

Ghike²,

Jain³

et al. 2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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Portal vein cavernoma is a rare disease resulting from extrahepatic portal vein thrombosis and development from collateral venous circulation. It is a rare condition affecting both adults and children with equal gender distribution. Both local and systemic factors may contribute to development of portal vein thrombosis. Once there is portal vein thrombosis, cavernous transformation occurs in 5 weeks to 12 months of thrombotic event. We report a case of primigravida with portal vein cavernoma who presented to us in last trimester. Cesarean section was done with primary indication with premature rupture of membrane with poor bishop score. Cesarean section was given priority considering associated digestive varices. Both maternal and fetal outcome was good.

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Pregnancy outcomes in patients with portal cavernoma: A case series study

Conthe

Ibáñez‐Samaniego

Muñoz

et al. 2023

Intl J Gynecology & Obste

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ObjectiveNon‐cirrhotic portal vein cavernoma (PVC) is a cause of portal hypertension (PH) frequently affecting women of childbearing age. Cavernous transformation of the portal vein is frequently associated with prothrombotic disorders and often entails multiple hemodynamic changes, porto‐collateral shunt development and thrombopenia, all of which can affect the course of pregnancy. Our aim was to evaluate the risk of PH‐related complications and pregnancy outcomes in patients with PVC.MethodsRetrospective case series study of patients with PVC undergoing pregnancy in a tertiary care hospital.ResultsEight pregnancies fulfilled the eligibility criteria. All patients had a predisposing factor for PVC. One episode of variceal bleeding was reported at week 28. Six cesarean sections were scheduled to avoid labor while two urgent surgeries were indicated due to fetal distress and intrauterine growth restriction (IUGR). In all but one case, anticoagulation was prescribed after delivery. No hemorrhagic or thrombotic complications were reported. There were four cases of IUGR with no case of miscarriage or stillbirth.ConclusionPregnancy in patients with PVC has an overall favorable outcome albeit a higher risk of PH‐derived complications, and IUGR may be expected. Hence, PVC must not be considered a contraindication for pregnancy although larger prospective studies are necessary.

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Pregnancy and Delivery in Patients with Portal Vein Cavernoma

Cited by 10 publications

References 15 publications

Portal vein thrombosis during pregnancy

Portal vein thrombosis during pregnancy

A Rare Case of Portal Vein Cavernoma with Pregnancy

Pregnancy outcomes in patients with portal cavernoma: A case series study

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