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Labour outcome for women following successful external cephalic version (ECV) was evaluated in a prospective case control study. ECV was successfully performed on 93 women in a dedicated ECV clinic at St Mary's Hospital, Portsmouth between 2004 and 2006. In the study group, 50% (n = 93) of women had a successful ECV. There were 103 women in the control group. There was no significant difference in the rate of instrumental deliveries between the study and the control groups. The rate for caesarean section was higher in the ECV group (18.2, n = 93) compared with the control group (7.7, n = 103; p < 0.028). When compared with the control group, the study group had a higher epidural rate (p < 0.016), oxytocin augmentation (p < 0.001), induction of labour rate (p < 0.009), electronic fetal monitoring (EFM) (p < 0.0001), abnormal fetal heart rate (p < 0.014) and birth in main unit (p < 0.001). Our data provide useful guidance to women undergoing ECV.

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Synthesis of total eighteen 2-amino-substituted 4-coumarinylthiazoles including sixteen new compounds (3a-o and 5b) bearing the benzenesulfonamide moiety is described in the present report. All the synthesized target compounds were examined for their in vivo anti-inflammatory (AI) activity and in vitro antimicrobial activity. Results revealed that six compounds (3 d, 3 f, 3 g, 3 h, 3 j and 3 n) exhibited pronounced anti-inflammatory activity comparable to the standard drug indomethacin. AI results were further confirmed by the docking studies of the most active (3n) and the least active compound (3a) with COX-1 and COX-2 active sites. In addition, most of the compounds exhibited moderate antimicrobial activity against Gram-positive bacteria as well as fungal yeast, S. cervisiae. Comparison between 3 and 5 indicated that incorporation of additional substituted pyrazole nucleus into the scaffold significantly enhanced AI activity.