Pregnancy and birth after intracytoplasmic sperm injection with normal testicular spermatozoa in a patient with azoospermia and tail stump epididymal sperm

Povlsen, Betina Boel; Aw, Lin Da; Laursen, Rita Jakubcionyte; Esteves, Sandro C.; Humaıdan, Peter

doi:10.1590/s1677-5538.ibju.2015.0296

Cited by 7 publications

(3 citation statements)

References 21 publications

(29 reference statements)

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“…Case scenarios are commonly used in medical literature to report a particular clinical condition or contextualize a situation hoping for better comprehension ( 247 , 248 ). Although the use of clinical scenarios to illustrate a point may not apply to a slightly different scenario ( 54 ), Agarwal and colleagues utilized this method in their CPG ( 20 ) to personalize a message giving it a clinical perspective ( 90 ).…”

Section: Discussionmentioning

confidence: 99%

A Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation testing in specific male infertility scenarios

Esteves¹,

Agarwal

Cho

et al. 2017

Transl. Androl. Urol.

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BackgroundSperm DNA fragmentation (SDF) is recognized as a leading cause of male infertility because it can impair the paternal genome through distinct pathophysiological mechanisms. Current evidence supports SDF as a major factor in the pathophysiology of several conditions, including varicocele, unexplained infertility, assisted reproductive technology failure, and environmental lifestyle factors, although the mechanisms involved have not been fully described yet. Measurement of the levels of DNA fragmentation in semen provides valuable information on the integrity of paternal chromatin and may guide therapeutic strategies. A recently published clinical practice guideline (CPG) highlighted how to use the information provided by SDF testing in daily practice, which triggered a series of commentaries by leading infertility experts. These commentaries contained an abundance of information and conflicting views about the clinical utility of SDF testing, which underline the complex nature of SDF.MethodsA search of papers published in response to the CPG entitled “Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios” was performed within the Translational Andrology and Urology (TAU) website (http://tau.amegroups.com/). The start and end dates for the search were May 2017 and August 2017, respectively. Each commentary meeting our inclusion criteria was rated as “supportive without reservation”, “supportive with reservation”, “not supportive” or “neutral”. We recorded whether articles discussed either SDF characteristics as a laboratory test method or clinical scenarios, or both. Subsequently, we extracted the particulars from each commentary and utilized the ‘Strengths-Weaknesses-Opportunities-Threats’ (SWOT) analysis to understand the perceived advantages and drawbacks of SDF as a specialized sperm function method in clinical practice.ResultsFifty-eight fertility experts from six continents and twenty-two countries contributed commentaries. Overall, participants (87.9%; n=51) were supportive of the recommendations provided by the CPG on the utility of SDF testing based on clinical scenarios. The majority of participants made explicit remarks about both the clinical scenarios and SDF assays’ characteristics. Among ‘not supportive’ and ‘supportive with reservation’ participants, 75% (n=30/40) and 77.5% (n=31/40) expressed concerns related to technical limitations of SDF testing methods and clinical utility of the test in one or more clinical scenarios discussed in the CPG, respectively. The SWOT analysis revealed that the CPG provides a reasonable evidence-based proposal for integration of SDF testing in the routine daily practice. It also uncovered gaps of knowledge and threats limiting the widespread application of SDF in everyday practice, thus allowing the identification of opportunities to further refine SDF testing and its clinical utility.ConclusionsThe understanding of the role of SDF in male infertility requires an in-depth analysis of the multifactorial pat...

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Section: Discussionmentioning

confidence: 99%

A Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation testing in specific male infertility scenarios

Esteves¹,

Agarwal

Cho

et al. 2017

Transl. Androl. Urol.

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“…5 With the development of ICSI in 1992, a new treatment option has become available for male infertility, since the technique can be successfully used even for the most severe cases of oligoasthenoteratospermia (OAT) or azoospermia. 6…”

Section: Introductionmentioning

confidence: 99%

Factors associated with the success of intracytoplasmic sperm injection for the treatment of conjugal infertility

Nunes¹,

Vieira²,

Traebert³

2019

Hum. Reprod. Arch.

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Objectives: Obtaining and maintaining pregnancy after intracytoplasmic sperm injection (ICSI) may be affected by many technical factors. The goal of this study is to determine the rates of success from ICSI technique with established parameters and assess the associated factors to its success to treat infertility. Methods: A cross-sectional study involving 115 infertile couples submitted to ICSI was performed to test the association between technical aspects and success rates, from July 2013 to December 2014. Data collection was done through medical records. The bivariate associations were calculated by prevalence ratios and a Poisson regression was performed with significance level p < 0.05. Results: The aspiration of eight or more oocytes was 0.73 times (CI 95% 0.57-0.94) less associated (p = 0.014), but transferring two or more embryos was 1.75 times (CI 95% 1.54-1.99) more associated with the viable pregnancy (p < 0.001). The remaining characteristics of the ICSI procedures were not significantly associated with the expected outcome. Conclusions: The prevalence of the viable pregnancy after ICSI procedure was 40.9%. This index was positively influenced by the aspiration of less than eight oocytes and the transferring of two or more embryos.

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“…In vitro fertilization accompanied by PGD increases the chance of their fathering a healthy child ( 9 ). In azoospermia patients, pregnancy success and fertility may be achieved via intracytoplasmic sperm injection, using spermatozoa obtained from testis by microdissection testicular sperm extraction ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical features of carriers of reciprocal chromosomal translocations involving chromosome 2: report of nine cases and review of the literature

Zhang

et al. 2018

Int. braz j urol.

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Objective:To explore the clinical features of carriers of chromosome 2 translocations, enabling informed genetic counseling of these patients.Materials and Methods:Eighty-two male carriers of a translocation who were infertile or receiving fertility counseling were recruited. Cytogenetic analyses were performed using G-banding. A search of PubMed was performed to determine whether the identified translocations on chromosome 2 are involved in male infertility. The relationships of translocation breakpoints with male infertility and recurrent pregnancy loss were analyzed.Results:Of the 82 translocation carriers, 9 (11%) were carriers of a chromosome 2 translocation. Four cases had oligozoospermia or infertility, while five had normal semen. In an analysis of the literature, 55 patients who were carriers of chromosome 2 translocations were also reviewed. Breakpoints at 2p13 and 2q31 were observed in six patients each, and were the most common. Breakpoints at 2p23, 2p13, 2p11.2, 2q31, and 2q37 were associated to both pre-gestational and gestational infertility, while other breakpoints were associated with gestational infertility.Conclusions:All breakpoints at chromosome 2 were correlated with gestational infertility. Carriers of chromosome 2 translocations should therefore receive counseling to continue with natural conception and use of different technologies available via assisted reproductive technology, such as preimplantation genetic diagnosis.

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Pregnancy and birth after intracytoplasmic sperm injection with normal testicular spermatozoa in a patient with azoospermia and tail stump epididymal sperm

Cited by 7 publications

References 21 publications

A Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation testing in specific male infertility scenarios

A Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation testing in specific male infertility scenarios

Factors associated with the success of intracytoplasmic sperm injection for the treatment of conjugal infertility

Clinical features of carriers of reciprocal chromosomal translocations involving chromosome 2: report of nine cases and review of the literature

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