Pregnancy after corticosteroid administration in premature ovarian failure (polyglandular endocrinopathy syndrome)

Cowchock, F. Susan; McCabe, James L.; Montgomery, Bruce

doi:10.1016/0002-9378(88)90791-0

Cited by 66 publications

(22 citation statements)

References 2 publications

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“…The sparing of primordial follicles often observed aligns with the fact that they lack the theca layer of cells, and with the potential recoverability of follicular function following immunosuppressive corticosteroid therapy if pregnancy is desired. [36][37][38][39] Indeed, women with autoimmune POI appear to maintain a preserved follicular pool as evidenced by maintenance of serum anti-Mullerian hormone, sometimes for years after diagnosis; however, growing follicles eventually appear to be completely depleted. 40 It is possible that primordial follicles are also eventually depleted, either due to increased rate of recruitment or to immune-mediated destruction.…”

Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning

confidence: 99%

Ovarian autoimmune disease: clinical concepts and animal models

et al. 2014

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The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator (AIRE), a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

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Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning

confidence: 99%

Ovarian autoimmune disease: clinical concepts and animal models

et al. 2014

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“…However, the patient developed Addison's disease and was treated with corticosteroid replacement therapy. An uneventful pregnancy was achieved one year after commencement of corticosteroid replacement therapy 24 . Luborsky et al described two patients with documented POF who became pregnant, and each patient delivered a healthy infant after treatment with high doses of corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune oophoritis: Clinical presentation of an unusual clinical entity

Varras¹,

Anastasiadis²,

Panelos³

et al. 2013

OA Case Reports

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IntroductionAutoimmune oophoritis is a rare condition, which provokes ovarian failure with either primary amenorrhea or secondary amenorrhea and a subsequent loss of fertility and ovarian hormonal function. The purpose of this report is to document the clinical findings from two patients with autoimmune oophoritis. Cases reportTwo cases of autoimmune oophoritis are presented whose histopathological findings were consistent with international literature. Both cases were histopathologically characterised by lymphocytic and plasmacytic inflammatory infiltrations around the cystic follicles. The inflammation was located both in the theca and granular layers. ConclusionPatients with autoimmune oophoritis should be recognised by the histopathology of the ovarian biopsies as they are at an increased risk of developing other autoimmune disorders.

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“…In light of this hypothesis we decided to start a corticosteroid treatment, however this strategy did not affect FSH, LH, estradiol level as well as ovarian volume and architecture in a 10 months follow-up period. On average, a two-three months period of corticosteroid treatment has been found to be sufficient to resume the ovarian function in selected POI patients (Forges 2; [2, 3, 6]) although in rare cases it had to be prolonged for up to 1 year [9]. A possible role of inactivating FSH receptor mutation in the etiopathogenesis of POI in our patient may be hypothesized, as it has been demonstrated that, similarly to what has been found in our patient, affected women show normal or low normal AMH level [13]; yet, normal AMH levels have been detected also in women with POI due to steroidogenic cell autoimmunity [15].…”

Section: Discussionmentioning

confidence: 99%

Resumption of ovarian function after 4 years of estro-progestin treatment in a young woman with Crohn’s disease and premature ovarian insufficiency: a case report

Caroppo¹,

D’Amato²

2012

J Assist Reprod Genet

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Purpose To report the long-term management of a case of premature ovarian insufficiency of unknown origin in a young woman with Crohn's disease. Method Here is reported the case of a 20 years old woman with Cronh's disease presenting with two years amenorrhea and FSH and LH levels of 255 mIU/ml and 182 mIU/ml respectively, who received 10 months corticosteroid treatment followed by 7 years of estro-progestin treatment.

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Pregnancy after corticosteroid administration in premature ovarian failure (polyglandular endocrinopathy syndrome)

Cited by 66 publications

References 2 publications

Ovarian autoimmune disease: clinical concepts and animal models

Ovarian autoimmune disease: clinical concepts and animal models

Autoimmune oophoritis: Clinical presentation of an unusual clinical entity

Resumption of ovarian function after 4 years of estro-progestin treatment in a young woman with Crohn’s disease and premature ovarian insufficiency: a case report

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