Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

Quirk, Gregory J.; Beer, Jennifer S.

doi:10.1016/j.conb.2006.07.004

Cited by 613 publications

(474 citation statements)

References 47 publications

Supporting

Mentioning

445

Contrasting

Unclassified

Order By: Relevance

“…Our aim was to identify and isolate the primary pathway thought to drive suppression of fear during extinction retrieval (Quirk and Beer, 2006), a neuronal subpopulation that accounts for o10% of all IL neurons (Gabbott et al, 2005). To account for variation in FG uptake, we report the percentage of FGlabeled neurons that were positive for c-fos (as opposed to total cell counts), as an indication of the degree to which the IL-BLA pathway was activated during extinction retrieval.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

Rey

Lipps

Shansky

2013

Neuropsychopharmacol

100

View full text Add to dashboard Cite

Post-traumatic stress disorder (PTSD) is twice as common in women as in men; it is a major public health problem whose neurobiological basis is unknown. In preclinical studies using fear conditioning and extinction paradigms, women and female animals with low estrogen levels exhibit impaired extinction retrieval, but the mechanisms that underlie these hormone-based discrepancies have not been identified. There is much evidence that estrogen can modulate dopaminergic transmission, and here we tested the hypothesis that dopamine-estrogen interactions drive extinction processes in females. Intact male and female rats were trained on cued fear conditioning, and received an intraperitoneal injection of a D1 agonist or vehicle before extinction learning. As reported previously, females that underwent extinction during low estrogen estrous phases (estrus/metaestrus/diestrus (EMD)) froze more during extinction retrieval than those that had been in the high-estrogen phase (proestrus; PRO). However, D1 stimulation reversed this relationship, impairing extinction retrieval in PRO and enhancing it in EMD. We also combined retrograde tracing and fluorescent immunohistochemistry to measure c-fos expression in infralimbic (IL) projections to the basolateral area of the amygdala (BLA), a neural pathway known to be critical to extinction retrieval. Again we observed diverging, estrous-dependent effects; SKF treatment induced a positive correlation between freezing and IL-BLA circuit activation in EMD animals, and a negative correlation in PRO animals. These results show for the first time that hormone-dependent extinction deficits can be overcome with non-hormone-based interventions, and suggest a circuit-specific mechanism by which these behavioral effects occur.

show abstract

Section: Discussionmentioning

confidence: 99%

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

Rey

Lipps

Shansky

2013

Neuropsychopharmacol

100

View full text Add to dashboard Cite

show abstract

“…Chronic elevation of DA neural firing in the nucleus accumbens, which is induced by strong stimulant exposure among rodents and nonhuman primates, downregulates tonic DA activity, sensitizes phasic DA responding to such stimulants, and suppresses the strength of developing connections between mesolimbic structures and the PFC (see Thomas, Beurrier, Bonci, & Malenka 2001;Vezina, 2004). Given the importance of the prefrontal cortex and its interconnections for decision making, planning, and other executive functions (e.g., Floresco & Magyar, 2006), such findings have obvious implications for the development of self-regulatory behavior (e.g., Davidson, Putnam, & Larson, 2000;Quirk & Beer, 2006).…”

Section: Emotion Dysregulation and Youth Psychopathologymentioning

confidence: 99%

Future Directions in Emotion Dysregulation and Youth Psychopathology

Beauchaine

2015

Journal of Clinical Child & Adolescent Psychology

307

321

View full text Add to dashboard Cite

“…Subregions of the PFC also participate during fear learning (11,12). Whereas consistent data link greater ventromedial PFC (VMPFC) activity to reduction in fear during extinction learning (13)(14)(15), more variable findings characterize lateral regions of the PFC.…”

mentioning

confidence: 99%

Distinct neural signatures of threat learning in adolescents and adults

Lau

Britton

Nelson

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

169

175

View full text Add to dashboard Cite

Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their ability to form clear-cut threat categories, allowing pervasive fears to manifest. Here we developed a discrimination learning paradigm that assesses the ability to categorize threat from safety cues to test these hypotheses on age differences in neurodevelopment. In experiment 1, we first demonstrated the capacity of this paradigm to generate threat/safety discrimination learning in both adolescents and adults. Next, in experiment 2, we used this paradigm to compare the behavioral and neural correlates of threat/safety discrimination learning in adolescents and adults using functional MRI. This second experiment yielded three sets of findings. First, when labeling threats online, adolescents reported less discrimination between threat and safety cues than adults. Second, adolescents were more likely than adults to engage early-maturing subcortical structures during threat/safety discrimination learning. Third, adults' but not adolescents' engagement of late-maturing prefrontal cortex regions correlated positively with fear ratings during threat/safety discrimination learning. These data are consistent with the role of dorsolateral regions during category learning, particularly when differences between stimuli are subtle [Miller EK, Cohen JD (2001) Annu Rev Neurosci 24:167-202]. These findings suggest that maturational differences in subcortical and prefrontal regions between adolescent and adult brains may relate to age-related differences in threat/safety discrimination. amygdala | brain development | discriminative fear conditioning | threat responding | anxiety

show abstract

Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

Cited by 613 publications

References 47 publications

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

Future Directions in Emotion Dysregulation and Youth Psychopathology

Distinct neural signatures of threat learning in adolescents and adults

Contact Info

Product

Resources

About