Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype

Bertolino, Alessandro; Rubino, Valeria; Sambataro, Fabio; Blasi, Giuseppe; Latorre, Valeria; Fazio, Leonardo; Caforio, Grazia; Petruzzella, Vittoria; Kolachana, Bhaskar; Hariri, Ahmad R.; Meyer‐Lindenberg, Andreas; Nardini, Marcello; Weinberger, Daniel R.; Scarabino, Tommaso

doi:10.1016/j.biopsych.2006.03.078

Cited by 160 publications

(165 citation statements)

References 66 publications

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“…One implication of smaller COMT-associated hippocampal volume may be dysfunction in hippocampal-prefrontal cortex connections that support episodic memory. Consistent with this, Bertolino and colleagues 66 found that reduced hippocampal-prefrontal cortex coupling was associated with poorer memory retrieval in Val carriers. Further, Schott and colleagues 67 found that Val carriers had less functional connectivity between the hippocampus and prefrontal cortex during memory encoding.…”

Section: Discussionmentioning

confidence: 63%

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

Hayes

Logue

Reagan

et al. 2017

JPN

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Section: Discussionmentioning

confidence: 63%

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

Hayes

Logue

Reagan

et al. 2017

JPN

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“…Interestingly, the association between the COMT Val 158 Met polymorphism and temporal and frontal areas has also been explored in fMRI studies. The Val allele has been reported to be associated with a reduced activation of the medial temporal lobe during an episodic memory task in healthy controls, 54,85 whereas in schizophrenia the Met allele has been reported to be associated with a reduced activation in this area. 86 Moreover, a recent meta-analysis 87 that evaluated 20 studies involving mostly healthy individuals showed a significant association between the Val allele and increased prefrontal acti vation.…”

Section: 7984mentioning

confidence: 98%

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

Ira

Zanoni

Ruggeri

et al. 2013

J Psychiatry Neurosci

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“…The catechol-O-methyltransferase (COMT ) gene codes for an enzyme that metabolizes catecholamines and it is particularly important for metabolizing prefrontal dopamine. A single point mutation in the COMT gene (val158met) is associated with differences in cognitive abilities (de Frias et al, 2004;Bruder et al, 2005;Bertolino et al, 2006;Aguilera et al, 2008;Stokes et al, 2011;Buckert et al, 2012). There is also some evidence that COMT genotype has a significant effect on the volume of gray matter and parietal lobe activity (Dumontheil et al, 2011).…”

Section: Mechanisms Of Tdcsmentioning

confidence: 99%

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Jones¹,

Crane²,

Feenstra³

et al. 2012

PsycEXTRA Dataset

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The nature of parietal contributions to working memory (WM) remain poorly understood but of considerable interest. We previously reported that posterior parietal damage selectively impaired WM probed by recognition (Berryhill and Olson, 2008a). Recent studies provided support using a neuromodulatory technique, transcranial direct current stimulation (tDCS) applied to the right parietal cortex (P4). These studies confirmed parietal involvement in WM because parietal tDCS altered WM performance: anodal current tDCS improved performance in a change detection task, and cathodal current tDCS impaired performance on a sequential presentation task. Here, we tested whether these complementary results were due to different degrees of parietal involvement as a function of WM task demands, WM task difficulty, and/or participants' WM capacity. In Experiment 1, we applied cathodal and anodal tDCS to the right parietal cortex and tested participants on both previously used WM tasks. We observed an interaction between tDCS (anodal, cathodal), WM task difficulty, and participants' WM capacity. When the WM task was difficult, parietal stimulation (anodal or cathodal) improved WM performance selectively in participants with high WM capacity. In the low WM capacity group, parietal stimulation (anodal or cathodal) impaired WM performance. These nearly equal and opposite effects were only observed when the WM task was challenging, as in the change detection task. Experiment 2 probed the interplay of WM task difficulty and WM capacity in a parametric manner by varying set size in the WM change detection task. Here, the effect of parietal stimulation (anodal or cathodal) on the high WM capacity group followed a linear function as WM task difficulty increased with set size. The low WM capacity participants were largely unaffected by tDCS. These findings provide evidence that parietal involvement in WM performance depends on both WM capacity and WM task demands. We discuss these findings in terms of alternative WM strategies employed by low and high WM capacity individuals. We speculate that low WM capacity individuals do not recruit the posterior parietal lobe for WM tasks as efficiently as high WM capacity individuals. Consequently, tDCS provides greater benefit to individuals with high WM capacity.

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Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype

Cited by 160 publications

References 66 publications

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

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