Prefrontal-cingulate activation during executive control: which comes first?

Markela-Lerenc, Jaana; Ille, Nicole; Kaiser, Stefan; Fiedler, Peter; Mundt, Christoph; Weisbrod, Matthias

doi:10.1016/j.cogbrainres.2003.10.013

Cited by 174 publications

(210 citation statements)

References 51 publications

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“…Given the continuous nature of the task and the temporal resolution of fMRI acquisition, we could not directly distinguish between the monitoring and the implementation components of cognitive control. Although there are studies suggesting that ACC might be involved in control implementation itself (Posner and Rothbart, 1998;Markela-Lerenc et al, 2004;Roelofs et al, 2006), a large body of evidence in the cognitive control framework indicates that ACC is the monitoring component (Carter et al, 1998Garavan et al, 2002;Botvinick et al, 2004;Kerns et al, 2004b;Brown and Braver, 2005), whereas the prefrontal substrate actually implements the task control (Carter et study, we found that the PFC was more active in the incompatible versus the compatible condition but only in the early stage of the experiment when the task was less skillful. Furthermore, the PFC was more active in the early stage versus late stage but only for the more difficult incompatible condition.…”

Section: Discussionmentioning

confidence: 51%

Neural Changes in Control Implementation of a Continuous Task

Lungu¹,

Binenstock²,

Pline³

et al. 2007

J. Neurosci.

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It is commonly agreed that control implementation, being a resource-consuming endeavor, is not exerted continuously or in simple tasks. However, most research in the field was done using tasks that varied the need for control on a trial-by-trial basis (e.g., Stroop, flanker) in a discrete manner. In this case, the anterior cingulate cortex (ACC) was found to monitor the need for control, whereas regions in the prefrontal cortex (PFC) were found to be involved in control implementation. Whether or not the same control mechanism would be used in continuous tasks was an open question. In our study, we found that in a continuous task, the same neural substrate subserves control monitoring (ACC) but that the neural substrate of control implementation changes over time. Early in the task, regions in the PFC were involved in control implementation, whereas later the control was taken over by subcortical structures, specifically the caudate. Our results suggest that humans possess a flexible control mechanism, with a specific structure dedicated to monitoring the need for control and with multiple structures involved in control implementation.

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Section: Discussionmentioning

confidence: 51%

Neural Changes in Control Implementation of a Continuous Task

Lungu¹,

Binenstock²,

Pline³

et al. 2007

J. Neurosci.

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“…In the study of the interference effect of adults, it was the frontal region that inhibited the interference effects. Markela-Lerenc et al [6] found colors and meanings of words in incongruent conditions evoked a greater negativity in the 350-450 ms post-stimulus than that in congruent conditions in Stroop task. Source analysis of the difference wave (incongruent-congruent) indicated that a generator localized in the left prefrontal cortex contributed to this effect.…”

Section: Time Course Of Audio-visual Interference Inhibitionmentioning

confidence: 97%

“…In the study of Mager et al [5], when 30-year-old and 50-year-old adults were performing the Stroop task, a broad negativity developed after incongruent vs. congruent stimuli between 350 and 650 ms. An age-related increase of the latency and amplitude of this negativity was observed. Markela-Lerenc et al [6] found that N350-450 and P450-550 were greater in the incongruent as compared with the congruent and neutral conditions. Experimental materials may influence interferential effects of the Stroop task with regard to the processing course.…”

mentioning

confidence: 96%

Neural correlates of audio-visual modal interference inhibition investigated in children by ERP

Wang

Lin

Liang

et al. 2011

Sci. China Life Sci.

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In order to detect cross-sectional age characteristics of cognitive neural mechanisms in audio-visual modal interference inhibition, event-related potentials (ERP) of 14 10-year-old children were recorded while performing the words interference task. In incongruent conditions, the participants were required to inhibit the audio interference words of the same category. The present findings provided the preliminary evidence of brain mechanism for the children's inhibition development in the specific childhood stage. audio-visual modal, interference, inhibition, event-related potentials (ERP) Citation:Wang Y W, Lin C D, Liang J, et al. Neural correlates of audio-visual modal interference inhibition investigated in children by ERP. Sci China Life

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“…Concerning the Stroop color-word interference effect, source localization studies have suggested different but related brain generators for the N450 and LPC (Liotti et al 2000;Markela-Lerenc et al 2004;Hanslmayr et al 2008). …”

Section: Source Localization Of Erps Associated With Inhibition Betwementioning

confidence: 99%

Event-Related Brain Potentials in the Study of Inhibition: Cognitive Control, Source Localization and Age-Related Modulations

et al. 2014

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In the previous fifteen years, a variety of experimental paradigms and methods have been employed to study inhibition. In the current review, we analyze studies that have used the high temporal resolution of the event-related potential (ERP) technique to identify the temporal course of inhibition to understand the various processes that contribute to inhibition. ERP studies with a focus on normal aging are specifically analyzed because they contribute to a deeper understanding of inhibition. Three time windows are proposed to organize the ERP data collected using inhibition paradigms: the 200 ms period following stimulus onset; the period between 200 and 400 ms after stimulus onset; and the period between 400 and 800 ms after stimulus onset. In the first 200 ms, ERP inhibition research has primarily focused on N1 and P1 as the ERP components associated with inhibition. The inhibitory processing in the second time window has been associated with the N2 and P3 ERP components. Finally, in the third time window, inhibition has primarily been associated with the N400 and N450 ERP components. Source localization studies are analyzed to examine 2 the association between the inhibition processes that are indexed by the ERP components and their functional brain areas. Inhibition can be organized in a complex functional structure that is not constrained to a specific time point but, rather, extends its activity through different time windows. This review characterizes inhibition as a set of processes rather than a unitary process.

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Prefrontal-cingulate activation during executive control: which comes first?

Cited by 174 publications

References 51 publications

Neural Changes in Control Implementation of a Continuous Task

Neural Changes in Control Implementation of a Continuous Task

Neural correlates of audio-visual modal interference inhibition investigated in children by ERP

Event-Related Brain Potentials in the Study of Inhibition: Cognitive Control, Source Localization and Age-Related Modulations

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