Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory

Churchwell, John C.; Morris, Alvin L.; Musso, Nicholas D.; Kesner, Raymond P.

doi:10.1016/j.nlm.2009.12.008

Cited by 121 publications

(103 citation statements)

References 52 publications

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“…As well, the retention memory could be impaired (Aisa et al, 2007;Hui et al, 2011;Mello et al, 2009) or preserved (Grace et al, 2009;Lai et al, 2006). It has been reported that the mPFC could participate in spatial navigation through its interactions with the hippocampus (Churchwell, Morris, Musso, & Kesner, 2010;Wang & Cai, 2008) and that its lesion or inactivation impaired the WMT performance (Compton, Griffith, McDaniel, Foster, & Davis, 1997;Wang & Cai, 2008). However, several other studies contradicted these points (Granon & Poucet, 1995;Lacroix, White, & Feldon, 2002;Sullivan & Gratton, 2002).…”

Section: Discussionmentioning

confidence: 99%

Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex

Baudin

Blot

Verney

et al. 2012

Neurobiology of Learning and Memory

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Section: Discussionmentioning

confidence: 99%

Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex

Baudin

Blot

Verney

et al. 2012

Neurobiology of Learning and Memory

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“…Lesion, electrophysiological recording, and imaging studies in mammals, including humans, have shown that hippocampal subregions are differentially recruited at distinct stages of memory acquisition and recall, and that different components of the hippocampus are selectively involved in different memory operations [Bontempi et al, 1999;Ros et al, 2006;Ross and Eichenbaum, 2006;Kubik et al, 2007;Churchwell et al, 2010]. These particular memory operations are thought to endow hippocampal-dependent memories with special and distinctive functional properties, such as the capability to rapidly form arbitrary associations among multiple elements of different sensory modalities, to link items separated in space or time into a single memory representation, and to apply flexibly stored memories to novel situations.…”

Section: Dynamic Pattern Of DLV Activation Across the Stages Of Spatimentioning

confidence: 99%

Dynamics of Goldfish Subregional Hippocampal Pallium Activity throughout Spatial Memory Formation

Ocaña

Uceda²,

Árias³

et al. 2017

Brain Behav Evol

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The teleost fish hippocampal pallium, like the hippocampus of tetrapods, is essential for relational map-like spatial memories. In mammals, these relational memories involve the dynamic interactions among different hippocampal subregions and between the hippocampus-neocortex network, which performs specialized operations such as memory encoding and retrieval. However, how the teleost hippocampal homologue operates to achieve comparably sophisticated spatial cognition capabilities is largely unknown. In the present study, the progressive changes in the metabolic activity of the pallial regions that have been proposed as possible homologues of the mammalian hippocampus were monitored in goldfish. Quantitative cytochrome oxidase histochemistry was used to measure the level of activation along the rostrocaudal axis of the ventral (Dlv) and dorsal parts of the dorsolateral division (Dld) and in the dorsoposterior division (Dp) of the goldfish telencephalic pallium throughout the time course of the learning process of a spatial memory task. The results revealed a significant increase in spatial memory-related metabolic activity in the Dlv, but not in the Dld, suggesting that the Dlv, but not the Dld, is comparable to the amniote hippocampus. Regarding the Dlv, the level of activation of the precommissural Dlv significantly increased at training onset but progressively declined to finally return to the basal pretraining level when the animals mastered the spatial task. In contrast, the commissural Dlv activation persisted even when the acquisition phase was completed and the animal's performance reached an asymptotic level. These results suggest that, like the dentate gyrus of mammals, the goldfish precommissural Dlv seems to respond nonlinearly to increments of change in sensory input, performing pattern separation under highly dissimilar input patterns. In addition, like the CA3 of mammals, the commissural Dlv likely operates in a continuum between two modes, a pattern separation or storage operation mode at early acquisition when the change in the sensory input is high, probably driven by the precommissural Dlv output, and a pattern completion or recall operation mode when the animals have mastered the task and the change in sensory input is small. Finally, an unexpected result of the present study is the persistent activation of the area Dp throughout the complete spatial task training period, which suggests that the Dp could be an important component of the pallial network involved in spatial memory in goldfish, and supports the hypothesis proposing that the Dp is a specialized part of the hippocampal pallium network.

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“…In these studies, the medial division of the PFC has been a primary target of interest because it is thought to be functionally similar to the dorsolateral PFC in primates (Uylings et al 2003;Vertes 2006;Seamans et al 2008), which is the region commonly found to be involved in memory processes in humans. In rodents, mPFC lesions impair various forms of spatial memory (Lee and Kesner 2003;Jo et al 2007; Lee and Solivan 2008;Churchwell et al 2010). The mPFC has also been shown to be involved in a number of nonspatial memory tasks, including fear conditioning and extinction (Sotres-Bayon and Quirk 2010), transitive inference (DeVito et al 2010), and memory for sequential order (DeVito and Eichenbaum 2011).…”

mentioning

confidence: 99%

The medial prefrontal cortex is critical for memory retrieval and resolving interference

et al. 2013

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The prefrontal cortex (PFC) is known to be critically involved in strategy switching, attentional set shifting, and inhibition of prepotent responses. A central feature of this kind of behavioral flexibility is the ability to resolve conflicting response tendencies, suggesting a general role of the PFC in resolving interference. If so, the PFC should also be involved in memory retrieval, which involves competition between potential retrieval targets. Moreover, the PFC should be needed whenever interference is high, regardless of the strategic or attentional requirements of the task. To test this hypothesis, we temporarily inactivated the mPFC with muscimol and tested rats on several olfactory learning tasks. Rats given muscimol were able to learn a few discrimination problems when they were learned one at a time. However, they were severely impaired when they had to learn and remember many odors concurrently. Rats given muscimol also suffered greater interference when learning two lists of conflicting odor discrimination problems. Additionally, temporary mPFC inactivation during the acquisition of one set of odor memories actually improved the ability to learn a new set of conflicting odor memories. This paradoxical release from interference suggests that the mPFC plays an important role in acquiring and promoting the long term retrieval of memories. These results suggest that the mPFC plays a general role in resolving interference and that this is a key aspect of behavioral flexibility.

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Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory

Cited by 121 publications

References 52 publications

Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex

Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex

Dynamics of Goldfish Subregional Hippocampal Pallium Activity throughout Spatial Memory Formation

The medial prefrontal cortex is critical for memory retrieval and resolving interference

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