Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex

Stress and the social brain: behavioural effects and neurobiological mechanisms

“…Stress at other developmental stages also causes structural alterations. For instance, neonatal stress affected dendritic organization and synaptic plasticity in the PFC in rats [99][100][101] . Post-weaning social isolation specifically reduced the volume of posterodorsal component of the medial amygdala and of the right medial PFC in rats 102,103 .…”

Sex differences in depression-like behavior after nerve injury are associated with differential changes in brain-derived neurotrophic factor levels in mice subjected to early life stress

“…Previous studies have demonstrated that emotional dysfunction induced by persistent pain is related to functional alterations in the frontal cortex, hippocampus and striatum [9][10][11]. Neuronal dysfunction in these regions of the brain is also induced by early life stress [12][13][14]. Thus, we hypothesized that emotional dysfunction after neuropathic pain in adult mice is influenced by exposure to early life stress.…”

The different effects of maternal separation on spatial learning and reversal learning in rats

“…It is well known that MS rats showed different neurochemical alterations from NMS rats such as BDNF and 5-HT changes in juvenile, adolescent and young adult period which are induced by MS procedure [29,30]. And MS produced deficits in cognitive flexibility of adult rats along with an up-regulation of long term potentiation (LTP) in the mPFC [48]. The unpublished data of our lab also showed that the highest BDNF expression in the mPFC of NMS young adult rats hit bottom in it of MS rats, which may have an influence on the disappearance of age-related changes in cognitive flexibility induced by MS, but this still need further confirmation.…”