Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

“… 49 Furthermore, BAC reduced the surface tension, allowing the gel more dispersive power on the ocular surface. 51 Moreover, alpha-cyclodextrin allowed 20 times greater penetrance of cysteamine at a concentration of 5.5%. 49 The time to identification of cysteamine in the receptor compartment still remained at 1 hour.…”

“… 51 However, only sodium hyaluronate (0.3%) showed long-term stability and was greatest when dispensed in ampoules. 51 …”

“… 54 A study from 2016 considered hydrogel formulations for cysteamine hydrochloride 0.55% and BAC as a preservative. 51 Hydrogels can be pseudoplastic, transparent, and bioadhesive, thereby permitting prolonged drug release and, thus, optimizing bioavailability and compliance through less frequent drug administration. 51 Carbomer 974 (0.25%) and xanthan (0.3%) gels were proven to be of poor stability.…”

“… 51 Hydrogels can be pseudoplastic, transparent, and bioadhesive, thereby permitting prolonged drug release and, thus, optimizing bioavailability and compliance through less frequent drug administration. 51 Carbomer 974 (0.25%) and xanthan (0.3%) gels were proven to be of poor stability. 51 In contrast, sodium hyaluronate (0.3%), carbomer 934 (0.3%), and hydroxyethyl cellulose (0.8%) dispensed cysteamine over 45–50 minutes.…”

“… 51 Carbomer 974 (0.25%) and xanthan (0.3%) gels were proven to be of poor stability. 51 In contrast, sodium hyaluronate (0.3%), carbomer 934 (0.3%), and hydroxyethyl cellulose (0.8%) dispensed cysteamine over 45–50 minutes. 51 However, only sodium hyaluronate (0.3%) showed long-term stability and was greatest when dispensed in ampoules.…”