Preferential accumulation of gold nanorods into human skin hair follicles: Effect of nanoparticle surface chemistry

Mahmoud, Nouf N.; Alkilany, Alaaldin M.; Dietrich, Dörthe; Kärst, Uwe; Al‐Bakri, Amal G.; Khalil, Enam A.

doi:10.1016/j.jcis.2017.05.011

Cited by 58 publications

(43 citation statements)

References 43 publications

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“…As AuNPs are distributed into hair follicles, their hydrophilic substances may be found in the sebaceous gland system. 36 It is understandable that higher follicular density results in a higher absorption rate, which was confirmed several decades ago. 37 In addition, each hair follicle has a growth cycle.…”

Section: Follicular Routementioning

confidence: 88%

“…31 In addition, the follicular route has been considered, as NPs tend to accumulate in hair follicles. 36 Few experimental data exist on detailed penetration mechanisms, especially for the latter two approaches. Future studies should include the relationships between these three main routes and their respective weights, as well as the qualitative and quantitative distribution of metallic NPs in the skin and the effects of metallic NPs on skin keratinocytes, fibroblasts, immune cells, and hair-follicle cells.…”

Section: Limitations and Possible Future Research Prospectsmentioning

confidence: 99%

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Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Wang

Lai

Shao

et al. 2018

IJN

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Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating that skin exposure is a means for NPs to enter the body. The distribution and interaction of NPs with skin cells may cause toxic side effects. In this review, possible penetration pathways and related toxicity mechanisms are discussed. The limitations of current experimental methods on the penetration and toxic effects of metallic NPs are also described. This review contributes to a better understanding of the risks of topically applied metallic NPs and provides a foundation for future studies.

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Section: Follicular Routementioning

confidence: 88%

Section: Limitations and Possible Future Research Prospectsmentioning

confidence: 99%

Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Wang

Lai

Shao

et al. 2018

IJN

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“…217 Calibration was performed with spiked gelatine slices, which resulted in a limit of detection of 0.02 µg g -1 for gold using a quadrupole ICP-MS. Accumulation of Au in stratum corneum and in follicular hair was observed. 222 Niehoff et al applied similar LA-ICP-MS conditions to monitor the distribution of palladium-tagged nanoparticles used for delivery of a photosensitiser to tumor cells. The porphyrin-based photosensitiser complexed Pd as the central ion and was embedded in poly(lactic-coglycolic acid) nanoparticles with average diameter of 250 nm.…”

Section: Nanoparticle Standards and Model Solutionsmentioning

confidence: 99%

ICP-MS for the analysis at the nanoscale – a tutorial review

Meermann

Nischwitz

2018

J. Anal. At. Spectrom.

169

105

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The scope of this tutorial review is (i) to provide an overview on ICP-MS based techniques for the analysis of ENPs and natural nanoparticles/colloids by (a) “stand alone” ICP-MS and (b) hyphenated techniques; (ii) highlighting the benefits and pitfalls of each technique as well as providing practical advice regarding method development; (iii) illustrating the possibilities and limitations of each technique by practical applications from the recent literature.

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“…Several recent works deal with the possibilities offered by gold nanoparticles (AuNPs) to target skin diseases and transdermal administration of drugs. Mahmoud and coworkers have just described the preferred accumulation of AuNPs in hair follicles and their different behaviour depending on the surface charge of the nanoparticles . In the last year, it has also been synthetised a AuNPs‐based nanofiller for a polyelectrolyte membrane for transdermal drug delivery of the drug diltiazem hydrochloride.…”

Section: Figurementioning

confidence: 99%

Advanced Inorganic Nanosystems for Skin Drug Delivery

Carazo

Borrego-Sánchez

García‐Villén

et al. 2018

The Chemical Record

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On/into/through the skin drug delivery represents an attractive alternative for the oral route, providing local and/or systemic drug delivery. Due to its complex and well-organised structure, most of the drugs show difficulties to penetrate the human skin. Therefore, enormous efforts have been invested to develop intelligent drug delivery systems overcoming the skin barrier with particular emphasis on increasing therapeutic activity and minimizing undesirable side-effects. Most of these strategies require the use of singular materials with new properties. In particular, and on the basis of their inherent properties, including biocompatibility, biodegradability and relative low-cost, inorganic nanoparticles are ideal candidates for the development of skin drug delivery systems. This review provides an updated and comprehensive overview of the state of the art in the trends towards skin drug delivery with a particular focus in the attractive alternative offered by inorganic-based nanosystems.

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Preferential accumulation of gold nanorods into human skin hair follicles: Effect of nanoparticle surface chemistry

Cited by 58 publications

References 43 publications

Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

ICP-MS for the analysis at the nanoscale – a tutorial review

Advanced Inorganic Nanosystems for Skin Drug Delivery

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