Preface

Avendaño, Carmen; Menéndez, J. Carlos

doi:10.1016/b978-0-444-62649-3.09994-4

Cited by 33 publications

(45 citation statements)

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“…It is used to treat Hodgkin’s disease, lymphomas, leukemia, Wegener’s granulomatosis, severe rheumatoid arthritis, and lupus erythematosus. It is also used in combination with other drugs to treat breast cancer, leukemia, and ovarian cancer ( 2 , 3 ). However, despite its wide range of application, CP also exhibit a wide range of adverse effects including reproductive toxicity in experimental animals and humans ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats

Torabi

Shafaroudi

Rezaei

2017

IJRM

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Background: Cyclophosphamide (CP) has been known as an anticancer drug with several side effects on various organs such as a male reproductive system that can cause infertility. Objective: To evaluate the possible combined effects of zinc oxide nanoparticles (nZno) and melatonin (Mel) on sperm parameters and histopathological changes of the testis in CP-treated rats. Materials and Methods: 42 adult male Wistar rats were divided into six groups. GI: control, GII: 60 mg/kg/wk CP, GIII and GIV, 10 mg/kg/wk Mel and 5mg/kg/wk nZno and GV: 5 mg/kg/wk nZno and 10 mg/kg/wk Mel were given 2 hr prior to CP injection, respectively,GVI: 5mg/kg/wk nZno and 10 mg/kg/wk Mel simultaneously. After 8 wk of treatment, rats were sacrificed and testis and epididymis were harvested for further evaluation. Results: The CP-treated group showed significant decreases in the body, testes and epididymis weights and sperm parameters (sperm count, viability, motility) with an increase abnormal sperms when compared with the control (p<0.001), as well as many histological alterations included decreased diameters of seminiferous tubules and Johnsen's Testicular Score (with degeneration, desquamation, multi-nucleated giant cell formation), whereas combined treatment (GV), showed more protective effects on CP-induced reproductive system damage compared with groups III or IV (p<0.001). Conclusion: These results suggest simultaneous administration of Mel and nZno have more effectively protections against CP-induced reproductive damage than Mel or nZno alone.

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Section: Introductionmentioning

confidence: 99%

Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats

Torabi

Shafaroudi

Rezaei

2017

IJRM

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“…Pyrazole and indazole derivatives constitute an important group of kinase inhibitors [ 10 , 11 , 12 , 13 ]. Several anticancer agents containing the above heterocyclic rings have been approved for use in the treatment of solid tumours and leukemia ( Scheme 1 ).…”

Section: Introductionmentioning

confidence: 99%

Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase

Czaja

Kujawski

Śliwa

et al. 2020

IJMS

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Vascular endothelial growth factor receptor 2 (VEGFR2) is a key receptor in the angiogenesis process. The VEGFR2 expression is upregulated in many cancers so this receptor is an important target for anticancer agents. In the present paper, we analyse interactions of several dimeric indazoles, previously investigated for anticancer activity, with the amino acids present in the VEGFR2 binding pocket. Using the docking method and MD simulations as well as theoretical computations (SAPT0, PIEDA, semi-empirical PM7), we confirmed that these azoles can efficiently bind into the kinase pocket and their poses can be stabilised by the formation of hydrogen bonds, π–π stacking, π–cation, and hybrid interactions with some amino acids of the kinase cavity like Ala866, Lys868, Glu885, Thr916, Glu917, and Phe918.

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“…The mechanism of action of anticancer antibiotics involves insertion into the DNA and destruction of the DNA by the production of superoxide. Platinum-based anticancer antibiotics are newer drugs used in the treatment of cancer [2,3].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Awareness about Anticancer Antibiotics among Dental Students

Natarajan

Ganapathy

Subhashree

2020

JPRI

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Cancer is considered to be one of the major threats throughout the world. Treatment for cancer involves chemotherapy, radiation therapy, and surgeries. Different groups of drugs are used for chemotherapy. Anticancer antibiotics are such groups that act against tumor cells that are in a phase of continuous division and do not harm the cells in the resting phase. This study was a question-based survey. A questionnaire about anticancer antibiotics, its types, it's uses, and the clinical scenario was administered to a group of dentists. The questionnaire had a set of questions and corresponding options, the participants had to choose one among the options. The questions were simple and easy. The results obtained were collected and tabulated. The participants were of equal ratio with 50 male and 50 female participants. About 57.1% of the participants were not aware about anticancer antibiotics. As dentists, it is important to know how to diagnose oral cancer, and the treatment options available for those patients. In this study, we could see that the participants’ knowledge about anticancer antibiotics was less than adequate. Proper training and conferences should be conducted to improve their knowledge.

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Preface

Cited by 33 publications

References 0 publications

Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats

Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats

Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase

Knowledge, Attitude and Awareness about Anticancer Antibiotics among Dental Students

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