Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats

Torabi, Fereshte; Shafaroudi, Majid Malekzadeh; Rezaei, Nourollah

doi:10.29252/ijrm.15.7.403

Cited by 49 publications

(30 citation statements)

References 31 publications

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“…In the present study, the high dose of ZnO-NPs induced severe necrosis in the seminiferous tubules, which indicate the ability of these nanoparticles to cross the blood-testis barrier. Previous studies have shown that ZnO-NPs can cross the blood vessels of testis [60]. In the present study, the rats treated with the high dose of nanoparticles had significantly elevated levels of MDA, liver enzymes, BUN, and creatinine levels.…”

Section: Comparative Discussionsupporting

confidence: 61%

Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus

et al. 2020

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In the present work, zinc oxide nanoparticles (ZnO-NPs) were synthesized in the presence of poly(ethylene glycol) which is a biocompatible agent in living systems. The sub-chronic effects of ZnO-NPs were investigated based on biochemical parameters and histological changes applied to Rattus norvegicus. The structural, morphology, and size characterization of nanoparticles were studied by applying techniques as XRD, SEM, FTIR, and TEM. 8-week intraperitoneal injection of ZnO-NPs at a dose of 100 mg/kg leads to significant changes in liver enzymes, malondialdehyde (MDA) content, and tissue histopathological changes. The animal group which was treated with 50 mg/kg of ZnO-NPs presented elevated blood urea nitrogen and creatinine levels, but the liver enzymes and liver histopathology were found to be in normal level. The rats exposed to increasing dose of ZnO-NPs (100 mg/kg) showed necrosis of germinal epithelium and sertoli cells in the seminiferous tubules. The current study clearly demonstrated the dose-dependent toxicity of zinc oxide nanoparticles.

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Section: Comparative Discussionsupporting

confidence: 61%

Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus

et al. 2020

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“…This phenomenon was likely caused by the mono diet or stress. The most damage was observed in a group of animals fed with ZnO-N and ZnC, although recent studies revealed that zinc and zinc nanoparticles have some protective effect on the liver [56–59].…”

Section: Discussionmentioning

confidence: 99%

Zinc phosphate-based nanoparticles as a novel antibacterial agent: in vivo study on rats after dietary exposure

Horký

Skaličková

Urbánková

et al. 2019

J Animal Sci Biotechnol

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BackgroundDevelopment of new nanomaterials that inhibit or kill bacteria is an important and timely research topic. For example, financial losses due to infectious diseases, such as diarrhea, are a major concern in livestock productions around the world. Antimicrobial nanoparticles (NPs) represent a promising alternative to antibiotics and may lower antibiotic use and consequently spread of antibiotic resistance traits among bacteria, including pathogens.ResultsFour formulations of zinc nanoparticles (ZnA, ZnB, ZnC, and ZnD) based on phosphates with spherical (ZnA, ZnB) or irregular (ZnC, ZnD) morphology were prepared. The highest in vitro inhibitory effect of our NPs was observed against Staphylococcus aureus (inhibitory concentration values, IC50, ranged from 0.5 to 1.6 mmol/L), followed by Escherichia coli (IC50 0.8–1.5 mmol/L). In contrast, methicillin resistant S. aureus (IC50 1.2–4.7 mmol/L) was least affected and this was similar to inhibitory patterns of commercial ZnO-based NPs and ZnO. After the successful in vitro testing, the in vivo study with rats based on dietary supplementation with zinc NPs was conducted. Four groups of rats were treated by 2,000 mg Zn/kg diet of ZnA, ZnB, ZnC, and ZnD, for comparison two groups were supplemented by 2,000 mg Zn/kg diet of ZnO-N and ZnO, and one group (control) was fed only by basal diet. The significantly higher (P < 0.05) Zn level in liver and kidney of all treated groups was found, nevertheless Zn NPs did not greatly influence antioxidant status of rats. However, the total aerobic and coliform bacterial population in rat feces significantly decreased (P < 0.05) in all zinc groups after 30 d of the treatment. Furthermore, when compared to the ZnO group, ZnA and ZnC nanoparticles reduced coliforms significantly more (P < 0.05).ConclusionsOur results demonstrate that phosphate-based zinc nanoparticles have the potential to act as antibiotic agents.Electronic supplementary materialThe online version of this article (10.1186/s40104-019-0319-8) contains supplementary material, which is available to authorized users.

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“…The interaction of Zn with cadmium in the adult testes has been explored by many researchers [ 41 ]. Zn deficiency in the testes is positively correlated with hypogonadism and improper development of secondary sexual characteristics [ 42 , 43 ]. Zn and Cd interactions are due to similarities in ion pairs, and they form a competitive interaction [ 44 ].…”

Section: Action Of Zn In the Testes Phasementioning

confidence: 99%

Role of Zinc (Zn) in Human Reproduction: A Journey from Initial Spermatogenesis to Childbirth

Vickram

Rohini

Srinivasan

et al. 2021

IJMS

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Zinc (Zn), the second-most necessary trace element, is abundant in the human body. The human body lacks the capacity to store Zn; hence, the dietary intake of Zn is essential for various functions and metabolism. The uptake of Zn during its transport through the body is important for proper development of the three major accessory sex glands: the testis, epididymis, and prostate. It plays key roles in the initial stages of germ cell development and spermatogenesis, sperm cell development and maturation, ejaculation, liquefaction, the binding of spermatozoa and prostasomes, capacitation, and fertilization. The prostate releases more Zn into the seminal plasma during ejaculation, and it plays a significant role in sperm release and motility. During the maternal, labor, perinatal, and neonatal periods, the part of Zn is vital. The average dietary intake of Zn is in the range of 8–12 mg/day in developing countries during the maternal period. Globally, the dietary intake of Zn varies for pregnant and lactating mothers, but the average Zn intake is in the range of 9.6–11.2 mg/day. The absence of Zn and the consequences of this have been discussed using critical evidence. The events and functions of Zn related to successful fertilization have been summarized in detail. Briefly, our current review emphasizes the role of Zn at each stage of human reproduction, from the spermatogenesis process to childbirth. The role of Zn and its supplementation in in vitro fertilization (IVF) opens opportunities for future studies on reproductive biology.

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Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats

Cited by 49 publications

References 31 publications

Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus

Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus

Zinc phosphate-based nanoparticles as a novel antibacterial agent: in vivo study on rats after dietary exposure

Role of Zinc (Zn) in Human Reproduction: A Journey from Initial Spermatogenesis to Childbirth

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