Preface

Nash, Tony; Dalziel, Bob; Fitzgerald, Ross

doi:10.1016/b978-0-12-397188-3.00016-0

Cited by 5 publications

(3 citation statements)

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“…The mechanisms that typically maintain the homeostasis of various physiological systems are likely to contribute to host tolerance to infection ( 6 , 7 ). Cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic adenosine monophosphate (cAMP)-dependent Cl − channel expressed at the apical membrane of epithelial cells lining the tracheobronchial tree.…”

Section: Introductionmentioning

confidence: 99%

H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation

Cao

Chen

Xiang

et al. 2015

Mol Med

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The host tolerance mechanisms to avian influenza virus (H5N1) infection that limit tissue injury remain unknown. Emerging evidence indicates that cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent Clchannel, modulates airway inflammation. Janus tyrosine kinase (JAK) 3, a JAK family member that plays a central role in inflammatory responses, prominently contributes to the dysregulated innate immune response upon H5N1 attachment; therefore, this study aims to elucidate whether JAK3 activation induced by H5N1 hemagglutinin (HA) inhibits cAMP-dependent CFTR channels. We performed short-circuit current, immunohistochemistry and molecular analyses of the airway epithelium in Jak3 +/+ and Jak3 +/mice. We demonstrate that H5N1 HA attachment inhibits cAMP-dependent CFTR Clchannels via JAK3-mediated adenylyl cyclase (AC) suppression, which reduces cAMP production. This inhibition leads to increased nuclear factor-kappa B (NF-κB) signaling and inflammatory responses. H5N1 HA is detected by TLR4 expressed on respiratory epithelial cells, facilitating JAK3 activation. This activation induces the interaction between TLR4 and Gαi protein, which blocks ACs. Our findings provide novel insight into the pathogenesis of acute lung injury via the inhibition of cAMP-dependent CFTR channels, indicating that the administration of cAMP-elevating agents and targeting JAK3 may activate host tolerance to infection for the management of influenza virus-induced fatal pneumonia.

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Section: Introductionmentioning

confidence: 99%

H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation

Cao

Chen

Xiang

et al. 2015

Mol Med

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“…What polio-, variola, and measles virus share is dissemination from the initial infection site via lymph and (secondarily) blood as an obligate step in pathogenesis or transmission. Virus-programmed interorgan dissemination occurs in stages over days, as the virus productively infects one organ and proceeds to the next via lymph and blood [ 9 ]. Table 1 [ 10 ] summarizes the protection conferred by natural infection/vaccination for 20 common human viral pathogens.…”

mentioning

confidence: 99%

Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread

Yewdell

2021

PLoS Pathog

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“…Personal protective equipment (PPE) plays a very important role in controlling the spread of diseases through direct or indirect contact exposure. Viruses that can cause respiratory symptoms such as coronavirus, influenza virus, or rhinovirus are transmitted through contact with respiratory epithelial cells in the form of droplets or aerosols [ 7 ]. Recently, the increasing demand for PPE in this pandemic situation has resulted in a shortage of masks and protective clothing in several essential environments such as hospitals.…”

mentioning

confidence: 99%

Potential use of 3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride as an antimicrobial and antiviral agent for the disinfection of personal protective equipment

Kim

Youn²,

Kim³

et al. 2020

Clin Exp Vaccine Res

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The new coronavirus disease 2019 (COVID-19) is posing a dire health threat to the world. It has spread to more than 202 countries, and over 470,000 cases have been confirmed globally [1]. Approximately 9,241 cases have been confirmed in Korea as of March 26, 2020 [2], and the increasing numbers of patients are causing a significant medical burden. The virus is not a conventional coronavirus that infects the human body, but is an animal-originated virus adapted to the human body as a highly contagious pathogen [3]. The frontline protection primarily used in pandemic situations is vaccination. In addition, therapeutic agents for the disease should be available [4]. However, as of now, no vaccine has been developed for COVID-19, and it is expected that a vaccine will take a relatively long time to become available for public use. Recently, considerable efforts have been made to find an effective treatment for COVID-19 by repurposing or combining existing drugs [5]. Under this emergency situation, it is especially important for high-risk individuals to thoroughly prevent COVID-19 infection by maintaining personal hygiene and using protective equipment such as masks [6]. Personal protective equipment (PPE) plays a very important role in controlling the spread of diseases through direct or indirect contact exposure. Viruses that can cause respiratory symptoms such as coronavirus,

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Preface

Cited by 5 publications

References 0 publications

H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation

H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation

Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread

Potential use of 3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride as an antimicrobial and antiviral agent for the disinfection of personal protective equipment

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