Preeclamptic placental stress and over expression of mitochondrial HSP70

Perumal, Ekambaram; Lavanya, S.; Uthra, Venkatraman

doi:10.1515/cclm.2009.247

Cited by 43 publications

(27 citation statements)

References 43 publications

(40 reference statements)

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“…The increase in oxidative stress and nitrative stress observed in cord blood RBC in this study is in coherence with the evidence observed till date, thus suggesting their signifi cant role in the pathophysiology of preeclampsia (34). Many studies confi rm that levels of antioxidants are reduced in the sera, placentas and placental mitochondria of preeclamptic women (31,32,35,36). Similarly in the present study, it was noted that the antioxidant status in preeclamptic cord blood RBC was signifi cantly decreased compared with the normotensive sample.…”

Section: Discussionsupporting

confidence: 91%

“…1), indicating that both yeast species are effective in reducing the ROS-mediated hemolysis in the preeclamptic sample. Studies have demonstrated that oxidative stress is one of the key factors in complicating preeclampsia which results in preterm birth (31). Oxidative stress is the presence of ROS in excess of the buffering capacity of available antioxidants (32).…”

Section: Discussionmentioning

confidence: 99%

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Preeclamptic cord blood hemolysis and the effect of Monascus purpureus and Saccharomyces cerevisiae in modulating preeclamptic stress

Perumal¹,

Jayachandran²,

Venkatraman³

et al. 2013

BLL

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Abstract:Background: Preeclampsia is associated with impaired antioxidant defense that results in maternofetal complications. In addition to antioxidant defi ciency, hemolytic disorder has also been observed in preeclamptic mother.Methods: This study aims in analyzing the fetal complications using cord blood RBC (red blood cell); further the antihemolytic and antioxidant effi ciency of two common probiotic yeasts Monascus purpureus and Saccharomyces cerevisiae in preeclamptic and normotensive RBCs were assessed.Results: There was a signifi cant decrease in the antioxidant status (p<0.05) with increased oxidative stress, nitrative stress (p<0.05) and hemolysis (p<0.001) in preeclamptic RBC comparatively. M. purpureus demonstrated a highly signifi cant reactive oxygen radical scavenging activity (p<0.001) whereas S. cerevisiae exhibited a highly signifi cant nitric oxide radical scavenging activity (p<0.001). It was noted that oxidative stress hemolysis was decreased with increased antioxidant level in cord blood RBC from both samples after incubation with both yeasts in a similar manner. The antihemolytic property of M. purpureus and S. cerevisiae suggests that S. cerevisiae functions effi ciently with increasing stress. Conclusion: This study demonstrates for the fi rst time that despite their differential scavenging activities, a diet rich in M. purpureus and S. cerevisiae could equally serve as a good natural supplement to alleviate the stress status in the preeclamptic fetus (Tab. 4, Fig. 1, Ref. 39). Full Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Preeclamptic cord blood hemolysis and the effect of Monascus purpureus and Saccharomyces cerevisiae in modulating preeclamptic stress

Perumal¹,

Jayachandran²,

Venkatraman³

et al. 2013

BLL

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show abstract

“…Studies have demonstrated that oxidative stress is one of the key factor in complicating preeclampsia which results in preterm birth (Padmini et al 2009b;Padmini & Lavanya, 2011;Padmini & Lavanya, 2009a). The first line of defense for oxidative stress is not sufficient enough to combat with the generated stress.…”

Section: Discussionmentioning

confidence: 99%

“…A significant decrease in the expression of HSP70 observed in the present study on addition of tea and mint extracts may be due to the restoration of cell homeostasis by maintaining the antioxidant status. This property is attributed to the flavonoids, polyphenols and minerals present in tea and mint extracts (Padmini et al 2009b;Padmini et al 2008a;Padmini et al 2008b).…”

Section: Discussionmentioning

confidence: 99%

“…HSP70 chaperones regulate important physiological processes such as cell cycle, cell differentiation and programmed cell death (Mayer & Bukau, 2005;Cobreros et al 2008). The over expression of HSP70 in relation to the oxidative stress generated in preeclamptic condition suggest their protective role in stress management prolonging the cell survival in the placental endothelial cells during preeclampsia (Padmini et al 2009b;Padmini & Lavanya, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Tea and Mint Extracts Modulate the HSP70 Expression in Preeclamptic Placental Explant

Padmini¹

2012

J. App. Pharm. Sci.

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Heat shock protein 70 is a molecular chaperone which expressed during oxidative stress to protect the cell from damage. Preeclampsia is a hypertensive disorder with an oxidative stress imbalance. Antioxidant defenses appear to be depleted during preeclampsia resulting in increased oxidative stress. Various alternative medicines are employed to increase the endogenous antioxidant level during preeclampsia. The aim of the present study was to determine the modulatory effect of medicinal plants, Camellia sinensis and Mentha spicata on oxidative stress, antioxidant and thiol status using placental explant as the model system. Placental explants were cultured from the placental tissues of both normotensive and preeclamptic subjects. The lipid peroxide, total antioxidant capacity, glutathione redox ratio, HSP70 levels were measured in the placental explants with and without incubation with tea, mint and mint-tea. The addition of these three extracts increased the TAC and GRR in both placental explants with decrease in the LPO level. The expression of HSP70 also decreased more significantly in preeclamptic explants on addition of tea and mint extracts due to the restoration of cell homeostasis via maintaining the antioxidant status. In view of the above results, mint-tea may emerge as an effective antioxidant, preventing cell damage during stress condition.

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The Use of Antioxidants in Pre-eclampsia

Bilodeau

2012

Studies on Women's Health

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Preeclamptic placental stress and over expression of mitochondrial HSP70

Cited by 43 publications

References 43 publications

Preeclamptic cord blood hemolysis and the effect of Monascus purpureus and Saccharomyces cerevisiae in modulating preeclamptic stress

Preeclamptic cord blood hemolysis and the effect of Monascus purpureus and Saccharomyces cerevisiae in modulating preeclamptic stress

Tea and Mint Extracts Modulate the HSP70 Expression in Preeclamptic Placental Explant

The Use of Antioxidants in Pre-eclampsia

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