Preeclamptic cord blood hemolysis and the effect of Monascus purpureus and Saccharomyces cerevisiae in modulating preeclamptic stress

Abstract

Abstract:Background: Preeclampsia is associated with impaired antioxidant defense that results in maternofetal complications. In addition to antioxidant defi ciency, hemolytic disorder has also been observed in preeclamptic mother.Methods: This study aims in analyzing the fetal complications using cord blood RBC (red blood cell); further the antihemolytic and antioxidant effi ciency of two common probiotic yeasts Monascus purpureus and Saccharomyces cerevisiae in preeclamptic and normotensive RBCs were assessed.Results: There was a signifi cant decrease in the antioxidant status (p<0.05) with increased oxidative stress, nitrative stress (p<0.05) and hemolysis (p<0.001) in preeclamptic RBC comparatively. M. purpureus demonstrated a highly signifi cant reactive oxygen radical scavenging activity (p<0.001) whereas S. cerevisiae exhibited a highly signifi cant nitric oxide radical scavenging activity (p<0.001). It was noted that oxidative stress hemolysis was decreased with increased antioxidant level in cord blood RBC from both samples after incubation with both yeasts in a similar manner. The antihemolytic property of M. purpureus and S. cerevisiae suggests that S. cerevisiae functions effi ciently with increasing stress. Conclusion: This study demonstrates for the fi rst time that despite their differential scavenging activities, a diet rich in M. purpureus and S. cerevisiae could equally serve as a good natural supplement to alleviate the stress status in the preeclamptic fetus (Tab. 4, Fig. 1, Ref. 39). Full Text in PDF www.elis.sk.

Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes

“…80 Therefore, the physiologic consequences of PEC extend beyond the maternal environment and contribute to fetal complications. A study by Ekambaram et al 37 investigated the antihemolytic and antioxidant efficiency of two probiotic yeasts ( Monascus purpureus and Saccharomyces cerevisiae ) on fetal cord blood red blood cells (RBC) of infants born to PEC mothers as compared to healthy normotensive controls. The red blood cells of the PEC sample were found to have low anti-oxidant status ( P <0.05), increased oxidative stress, ( P <0.05), increased nitrative stress ( P <0.05), and increased hemolysis ( P <0.001).…”

Preeclampsia at the molecular level

“…Ekambaram et al demonstrated that a diet rich in yeast species Monascus purpureus and Saccharomyces cerevisiae could serve as a good natural antioxidant source and probiotic supplement to alleviate the stress status of preeclamptic patients and their babies. They had significant catalase activity, inhibited formation of lipid peroxide and nitrite/nitrate in cord blood red blood count of preeclamptic and normotensive subjects [91].…”