Preeclampsia: Should be Predict and Prevent?

Clinical and Biochemical Markers for Prediction of Preeclampsia

“…In PE, defective invasion of the spiral arteries by cytotrophoblast cells is associated with inadequate uteroplacental blood flow [3,12,16]. Doppler ultrasonography might be used to assess the velocity of uterine blood flow and indirectly evaluate the trophoblastic invasion of the spiral arteries.…”

“…Major risk factors for PE are: nuliparity, maternal age >40, prior PE, anti phospholipid antibody syndrome, family history of pe in first-degree relative, renal disease, chronic hypertension, diabetes mellitus, multiple gestations, strong family history of cv disease (heart disease or stroke in ≥2 first-degree relatives), obesity etc [1,3,12]. The maternal demographic characteristics, including medical and obstetric history, are potentially useful in screening for PE, but only when the various factors are incorporated into a combined algorithm derived by multivariate analysis [3].…”