Preeclampsia Risk and Angiotensinogen Polymorphisms M235T and AGT -217 in African American and Caucasian Women

Jenkins, Laura; Powers, Robert W.; Cooper, Mary; Gallaher, Marcia J.; Marković, Nina; Ferrell, Robert E.; Ness, Roberta B.; Roberts, James M.

doi:10.1177/1933719108316984

Cited by 20 publications

(23 citation statements)

References 20 publications

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“…12,21,23 Others, however, did not find a difference in the frequency of the two alleles. [24][25][26] Our findings are similar to those of Hopkins et al 27 who showed a higher frequency of T allele in Hispanic women with PE. A meta-analysis involving 17 studies concluded that C allele homozygotes had a 1.62 times higher risk of developing PE.…”

Section: Discussionsupporting

confidence: 90%

Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy

2010

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We investigated the variations in genes encoding endothelial nitric oxide synthase (NOS3), angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) in hypertensive disorders of pregnancy and the relationship between the polymorphisms and circulating nitric oxide (NO) and ACE levels in pregnant north Indian women. Frequencies of NOS3 G894T, 4b/a and T -786 -C, AGT T704C and ACE ins/del polymorphisms were studied in 342 subjects: 120 with preeclampsia (PE), 104 with gestational hypertension and 118 normotensive pregnant women. Variations were evaluated by polymerase chain reactionrestriction fragment length polymorphism. NO and ACE levels were determined using ELISA. There was no difference in the distribution of individual NOS3 and ACE polymorphisms in the study groups. Haplotype analysis showed a global difference in the NOS3 haplotype distribution between the PE and non-PE subjects (P¼0.03). The presence of AGT 704C allele was associated with a reduced risk of developing PE (odds ratio: 0.33, 95% CI: 0.19-0.59 in recessive mode). Circulating total NO and ACE levels were similar in three groups. No relationship was found between circulating NO levels and any of the NOS3 polymorphisms, but the circulating ACE levels were higher in those with DD genotype (Po0.05). In conclusion, there was no association between individual NOS3 and the ACE gene polymorphisms and hypertensive disorders of pregnancy in north Indian women. The presence of minor alleles at all the three sites in NOS3 seemed to increase the risk of PE, and AGT 704C allele was associated with a reduced PE risk. The complexity of interaction between these genetic abnormalities requires further studies.

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Section: Discussionsupporting

confidence: 90%

Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy

2010

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“…Of these papers, 26 were subsequently excluded: nine reported on overlapping populations, data of two could not be extracted, two were meta‐analyses, one was a family‐based study, 11 considered other endpoints and one did not exclude PE patients superimposed on pre‐existing hypertension in the PE cases. In four papers for the M235T polymorphism, the results were based on two different populations (Ward et al, 1993; Guo et al, 1997; Curnow et al, 2000; Jenkins et al, 2008); we considered these populations separately in the meta‐analysis. Finally, 31 (in 27 articles involving 2555 patients and 6114 controls) and six studies (in six articles involving 681 patients and 2076 controls), respectively, were considered for the meta‐analysis on the AGT M235T and T174M polymorphisms (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Angiotensinogen Gene M235T and T174M Polymorphisms and Susceptibility of Pre‐Eclampsia: A Meta‐Analysis

Lin

Lei

Yuan³

et al. 2012

Annals of Human Genetics

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SummaryThere are controversies in reports on the association of the angiotensinogen (AGT ) gene polymorphisms with the risk of developing pre-eclampsia (PE). We performed a meta-analysis to examine the association between the AGT polymorphisms and PE risk: M235T (31 studies involving 2555 patients and 6114 controls) and T174M (six studies involving 681 patients and 2076 controls). For the M235T polymorphism, the TT genotype increased the PE risk as compared to the MM genotype (odds ratio 1.61, 95% confidence intervals 1.22-2.14, P = 0.001). When stratified by ethnicity, the TT genotype remained significantly associated with higher PE risk in Caucasians and Mongolians but not in Africans. Similar results were also obtained under all three genetic models of the M235T polymorphism. For the T174M polymorphism, no significant association was found in the comparisons (MT vs. TT and MM vs. TT) and under any genetic models. The analysis excluding the highly significant Hardy-Weinberg equilibrium-violating studies and sensitivity analysis further strengthened the validity of these associations. No publication bias was observed in this study. This meta-analysis demonstrates that the AGT M235T polymorphism is significantly associated with PE whereas the T174M polymorphism is not.

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“…[8][9][10] To date, large numbers of epidemiological studies have been performed to examine the relationship between the AGT M235T polymorphism and risk of PE. 8,[11][12][13][14][15][16] The results, however, were controversial in different studies. Some investigators reported that the AGT M235T polymorphism was associated with the risk of PE in Caucasian 5,17,18 and Japanese patients.…”

Section: Introductionmentioning

confidence: 99%

AGT M235T polymorphism contributes to risk of preeclampsia: evidence from a meta-analysis

Sui

Zhang

Deng

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Objective: Preeclampsia a hypertensive disorder of pregnancy that mainly manifests as high blood pressure and proteinuria. Angiotensinogen (AGT) plays important roles in the regulation of blood pressure. The purpose of this study was to investigate the relationship between AGT M235T polymorphism and risk of preeclampsia using a meta-analysis. Methods: In this meta-analysis, 22 studies were selected by searching PubMed, EMBASE, ISI and CNKI databases up to October 2011. Crude odds ratios with corresponding 95% confidence intervals were used to evaluate the association between the AGT M235T polymorphism and risk of preeclampsia. Subgroup analyses were conducted by ethnicity and parity. Results: The TT genotype of the AGT M235T polymorphism was associated with elevated risk of preeclampsia in the overall analysis. In subgroup analysis according to ethnicity, increased risks were also found in Caucasians. After stratification based on parity, the excess risk was found in multigravida. Conclusions: These results showed that the TT genotype may play critical roles in the development of preeclampsia.

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Preeclampsia Risk and Angiotensinogen Polymorphisms M235T and AGT -217 in African American and Caucasian Women

Abstract: The frequency of angiotensinogen polymorphisms M235T and AGT -217 is different by race; however, these polymorphisms are not associated with an increased risk of preeclampsia.

Cited by 20 publications

References 20 publications

Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy

Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy

Angiotensinogen Gene M235T and T174M Polymorphisms and Susceptibility of Pre‐Eclampsia: A Meta‐Analysis

AGT M235T polymorphism contributes to risk of preeclampsia: evidence from a meta-analysis

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