Preeclampsia and eclampsia: the conceptual evolution of a syndrome

Erez, Offer; Romero, Roberto; Jung, Eun-Jung; Chaemsaithong, Piya; Bosco, Mariachiara; Suksai, Manaphat; Gotsch, Francesca

doi:10.1016/j.ajog.2021.12.001

Cited by 129 publications

(72 citation statements)

References 164 publications

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“…In addition, Age ≥ 35 was defined as advanced maternal age [ 30 ]. Gestational age < 34 was defined as early-onset preeclampsia and gestational age between 34 and 37 was defined as late-onset preeclampsia, whereas gestational age ≥ 37 was defined as full-term preeclampsia[ 31 , 32 ]. Low birth weight was defined as < 2500 g [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Development and evaluation of a nomogram for adverse outcomes of preeclampsia in Chinese pregnant women

Zheng

Zhang

Zhou

et al. 2022

BMC Pregnancy Childbirth

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Objective Preeclampsia, the main cause of maternal and perinatal deaths, is associated with several maternal complications and adverse perinatal outcomes. Some prediction models are uesd to evaluate adverse pregnancy outcomes. However, some of the current prediction models are mainly carried out in developed countries, and many problems are still exist. We, thus, developed and validated a nomogram to predict the risk of adverse pregnancy outcomes of preeclampsia in Chinese pregnant women. Methods The clinical data of 720 pregnant women with preeclampsia in seven medical institutions in Chongqing from January 1, 2010, to December 31, 2020, were analyzed retrospectively. The patients were divided into two groups: 180 cases (25%) with adverse outcomes and 540 cases (75%) without adverse outcomes. The indicators were identified via univariate analysis. Logistic regression analysis was used to establish the prediction model, which was displayed by a nomogram. The performance of the nomogram was evaluated in terms of the area under the receiver operating characteristic (ROC) curve, calibration, and clinical utility. Results Univariate analysis showed that 24 indicators were significantly different (P < 0.05). Logistic regression analysis showed that gestational age, 24 h urine protein qualitative, and TT were significantly different (P < 0.05). The area under the ROC curve was 0.781 (95% CI 0.737–0.825) in training set and 0.777 (95% CI 0.689–0.865) in test set. The calibration curve of the nomogram showed good agreement between prediction and observation. The analysis of the clinical decision curve showed that the nomogram is of practical significance. Conclusion Our study identified gestational age, 24 h urine protein qualitative, and TT as risk factors for adverse outcomes of preeclampsia in pregnant women, and constructed a nomogram that can easily predict and evaluate the risk of adverse pregnancy outcomes in women with preeclampsia.

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Section: Methodsmentioning

confidence: 99%

Development and evaluation of a nomogram for adverse outcomes of preeclampsia in Chinese pregnant women

Zheng

Zhang

Zhou

et al. 2022

BMC Pregnancy Childbirth

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“…Preeclampsia is a pregnancy complication and a leading cause of maternal and perinatal morbimortality and iatrogenic prematurity. 1e3 Although its etiology is not completely understood, 4,5 it is accepted that this condition relies on placental insufficiency and maternal cardiovascular maladaptation underlined by angiogenic imbalance, endothelial dysfunction, coagulopathy, and complement dysregulation, 6e8 which lead clinically to hypertension and proteinuria that can progress to multiorgan dysfunction during pregnancy. The multifactorial nature of preeclampsia explains a variable clinical/laboratory presentation, mainly determined by gestational age at onset (early vs late).…”

Section: Introductionmentioning

confidence: 99%

Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

Palomo

Youssef

Ramos

et al. 2022

American Journal of Obstetrics and Gynecology

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“…This is supported by a previous study comparing circulating biomarkers in pregnant women with COVID-19 and those of women with preeclampsia, which demonstrated that preeclampsia and severe COVID-19 display distinct biomarker profiles 145 . Moreover, preeclampsia is a placental disease that is usually resolved after the delivery of this organ 142,146,147 ; by contrast, maternal recovery from COVID-19 prior to delivery results in the disappearance of preeclampsia-like symptoms 54,136 .…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

Gomez‐Lopez

Romero²,

Escobar

et al. 2022

Preprint

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Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we profiled the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and showed alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 showed enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis. Shared and pregnancy-specific proteomic changes were identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-pregnant individuals display a stronger response to repel infection. Furthermore, the plasma proteome can accurately identify COVID-19 patients, even when asymptomatic or with mild symptoms. This study represents the most comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients.

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Preeclampsia and eclampsia: the conceptual evolution of a syndrome

Cited by 129 publications

References 164 publications

Development and evaluation of a nomogram for adverse outcomes of preeclampsia in Chinese pregnant women

Development and evaluation of a nomogram for adverse outcomes of preeclampsia in Chinese pregnant women

Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

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