Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

Palomo, Marta; Youssef, L.; Ramos, Angela; Torramadé-Moix, Sergi; Moreno-Castaño, Ana Belén; Martinez-Sanchez, Julia; Bonastre, L.; Pino, Marcos; Gómez-Ramírez, P.; MARTIN, Lidia; MATEOS, Estefania GARCIA.; Sánchez, Pablo; Fernández, Sara; Crovetto, F.; Escolar, Ginés; Carreras, Enric; Rebollo, Pedro Castro; Gratacós, E.; Crispi, F.; Díaz‐Ricart, Maribel

doi:10.1016/j.ajog.2022.03.048

Cited by 25 publications

(30 citation statements)

References 61 publications

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“…As preeclampsia is a primarily systemic endothelial-inflammatory obstetrical disease 54,140-144 , our findings support the fact that some perturbed pathways may be shared between COVID-19 and preeclampsia. This is supported by a previous study comparing circulating biomarkers in pregnant women with COVID-19 and those of women with preeclampsia, which demonstrated that preeclampsia and severe COVID-19 display distinct biomarker profiles 145 . Moreover, preeclampsia is a placental disease that is usually resolved after the delivery of this organ 142,146,147 ; by contrast, maternal recovery from COVID-19 prior to delivery results in the disappearance of preeclampsia-like symptoms 54,136 .…”

Section: Discussionsupporting

confidence: 72%

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

Gomez‐Lopez

Romero²,

Escobar

et al. 2022

Preprint

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Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we profiled the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and showed alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 showed enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis. Shared and pregnancy-specific proteomic changes were identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-pregnant individuals display a stronger response to repel infection. Furthermore, the plasma proteome can accurately identify COVID-19 patients, even when asymptomatic or with mild symptoms. This study represents the most comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients.

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Section: Discussionsupporting

confidence: 72%

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

Gomez‐Lopez

Romero²,

Escobar

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…This hypothesis is supported by the presence of distinctive biomarker patterns in COVID-19 and preeclampsia, which may be used to differentiate between the two conditions. 50 For instance, in one cohort, the majority of women with COVID-19 and symptoms of preeclampsia did not have abnormal soluble fms-like tyrosine kinase-1/placental growth factor (sFlt1/PlGF) ratios and other biomarkers associated with preeclampsia. 51 An alternative theory is that the vascular dysfunction caused by preeclampsia may predispose to COVID-19, much the same as is seen in essential hypertension.…”

Section: The Interplay Between Coronavirus Disease 2019 and Pregnancymentioning

confidence: 97%

A Review of Coronavirus Disease 2019 in Pregnancy

Zamparini

Saggers

Buga

2023

Semin Respir Crit Care Med

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Pregnancy is an independent risk factor for morbidity and mortality in coronavirus disease 2019 (COVID-19) with increased rates of operative delivery, intensive care unit admission, and mechanical ventilation as well as a possible increased risk of death, independent of other risk factors, compared with nonpregnant women with COVID-19. Furthermore, pregnancy outcomes are worse in those with COVID-19 with increased risk for preeclampsia, venous thromboembolism, preterm birth, miscarriage, and stillbirth compared with pregnant women without COVID-19. Importantly, pregnant women of nonwhite ethnicity appear to be at greater risk of severe COVID-19, necessitating improved access to care and closer monitoring in these women. The management of COVID-19 in pregnancy is largely similar to that in nonpregnant people; however, there is an important emphasis on multidisciplinary team involvement to ensure favorable outcomes in both mother and baby. Similarly, vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is safe in pregnancy and improves maternal and neonatal outcomes.

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“…Literature that was published during the writing of this review directly compared the pathophysiology of pre-eclampsia and COVID-19. In this study, Palomo et al [ 132 ] compared endothelial inflammation and angiogenesis in pregnant patients with pre-eclampsia vs COVID-19 pneumonia vs normotensive controls. They measured circulating inflammatory markers in patient blood and found different biomarker profiles of coagulopathy, endothelial inflammation, and angiogenesis.…”

Section: Obstetric Populationmentioning

confidence: 99%

COVID-19 associated liver injury: A general review with special consideration of pregnancy and obstetric outcomes

Cooper¹,

Colletta²,

Asirwatham³

et al. 2022

World J Gastroenterol

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Liver injury is an increasingly recognized extra-pulmonary manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Coronavirus disease 2019 (COVID-19) associated liver injury (COVALI) is a clinical syndrome encompassing all patients with biochemical liver injury identified in the setting of SARS-CoV-2 infection. Despite profound clinical implications, its pathophysiology is poorly understood. Unfortunately, most information on COVALI is derived from the general population and may not be applicable to individuals under-represented in research, including pregnant individuals. This manuscript reviews: Clinical features of COVALI, leading theories of COVALI, and existing literature on COVALI during pregnancy, a topic not widely explored in the literature. Ultimately, we synthesized data from the general and perinatal populations that demonstrates COVALI to be a hepatocellular transaminitis that is likely induced by systemic inflammation and that is strongly associated with disease severity and poorer clinical outcome, and offered perspective on approaching transaminitis in the potentially COVID-19 positive patient in the obstetric setting.

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Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

Cited by 25 publications

References 61 publications

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma

A Review of Coronavirus Disease 2019 in Pregnancy

COVID-19 associated liver injury: A general review with special consideration of pregnancy and obstetric outcomes

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