Preeclampsia-An endothelial cell disorder plus “something else”?

Liston, W.A.; Kilpatrick, D. C.

doi:10.1016/0002-9378(90)90724-l

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…It has been proposed that product(s) of the fetal-placental unit enter the circulation and then initiate the maternal pathophysiologic changes of preeclampsia [18]. However, there is increasing evidence that both feto-placental and maternal factors interact in manifesting endothelial cell dysfunction and its clinical manifestations [15,19–21].…”

Section: Introductionmentioning

confidence: 99%

Interrelationship Between Markers of Oxidative Stress, Inflammation and Hematological Parameters Among Preeclamptic Nigerian Women

Ekun

Ogidi

Lawal

et al. 2018

Med Sci Monit Basic Res

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BackgroundPreeclampsia is a multifaceted pregnancy-related disorder affecting women and fetuses. A link between preeclampsia, oxidative stress, and inflammation has been suggested. This study evaluated the interrelationship between biomarkers of oxidative stress, inflammation, and hematological parameters among preeclamptic Nigerian women.Material/MethodsA cross-sectional study was conducted among 49 preeclamptic and 50 normotensive healthy pregnant women. Blood samples were obtained after 20-week gestation in all participants. Levels of superoxide dismutase (SOD), catalase, glutathione (GSH), malonaldehyde (MDA), total protein, high-sensitivity C-reactive protein (hs-CRP), and cardiac-specific troponin I (cTnI) were determined by spectrophotometric and ELISA techniques. FBC, prothrombin time, and activated partial thromboplastin time were determined using an auto-analyzer, Quick’s one-stage, and Proctor’s and Rappaport’s modification methods, respectively.ResultsThe mean SOD (0.051±0.050 vs. 0.073±0.047, p 0.029), catalase (2.62±1.93 vs. 8.48±4.40, p<0.001), GSH (49.05±17.57 vs. 187.10±56.07 p<0.001), platelet (127.63±89.75 vs. 267.16±212.82, p<0.001 were lower in preeclampsia. MDA (7.16±5.00 vs. 2.91±2.66, p<0.001), cTnI (0.46±0.31 vs. 0.13±0.14 p<0.001), PT (19.36±4.06 vs. 13.45±1.97 p<0.001), APTT (45.53±2.92 vs. 37.49±4.99; p<0.001) were higher in preeclampsia. Negative associations between SOD and MDA (r –0.527 p<0.001), CAT and MDA (r –0.469, p 0.001) and positive associations between catalase and hs-CRP (r 0.844, p 0.029), RBC and HB (r 0.442, p 0.001), platelet, and SOD (r 0.353, p 0.013) were observed among preeclamptic volunteers.ConclusionsPreeclampsia is associated with oxidative stress, derangement of hematological and coagulation homeostasis, as well as deleterious effects on the cardiovascular system.

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Section: Introductionmentioning

confidence: 99%

Interrelationship Between Markers of Oxidative Stress, Inflammation and Hematological Parameters Among Preeclamptic Nigerian Women

Ekun

Ogidi

Lawal

et al. 2018

Med Sci Monit Basic Res

View full text Add to dashboard Cite

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“…Although there is still no satisfactory explanation, primiparity is the strongest risk factor for preeclampsia occurring in 75% of the cases . A maternal inherited predisposition has been the focus of many studies , but inconsistency with epidemiological data has warranted a broader perspective . A well‐supported theory based on a maladapted maternal immune system, has given the role of the placenta/fetus increasing recognition .…”

Section: Introductionmentioning

confidence: 99%

Distribution of HLA‐G extended haplotypes and one HLA‐E polymorphism in a large‐scale study of mother–child dyads with and without severe preeclampsia and eclampsia

Nilsson

Djurisic

Andersen

et al. 2016

HLA

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The etiological pathways and pathogenesis of preeclampsia have rendered difficult to disentangle. Accumulating evidence points toward a maladapted maternal immune system, which may involve aberrant placental expression of immunomodulatory human leukocyte antigen (HLA) class Ib molecules during pregnancy. Several studies have shown aberrant or reduced expression of HLA-G in the placenta and in maternal blood in cases of preeclampsia compared with controls. Unlike classical HLA class Ia loci, the nonclassical HLA-G has limited polymorphic variants. Most nucleotide variations are clustered in the 5'-upstream regulatory region (5'URR) and 3'-untranslated regulatory region (3'UTR) of HLA-G and reflect a stringent expressional control. Based on genotyping and full gene sequencing of HLA-G in a large number of cases and controls (n > 900), the present study, which to our knowledge is the largest and most comprehensive performed, investigated the association between the HLA-G 14-bp ins/del (rs66554220) and HLA-E polymorphisms in mother and newborn dyads from pregnancies complicated by severe preeclampsia/eclampsia and from uncomplicated pregnancies. Furthermore, results from extended HLA-G haplotyping in the newborns are presented in order to assess whether a combined contribution of nucleotide variations spanning the 5'URR, coding region, and 3'UTR of HLA-G describes the genetic association with severe preeclampsia more closely. In contrast to earlier findings, the HLA-G 14-bp ins/del polymorphism was not associated with severe preeclampsia. Furthermore, the polymorphism (rs1264457) defining the two nonsynonymous HLA-E alleles, HLA-E*01:01:xx:xx and HLA-E*01:03:xx:xx, were not associated with severe preeclampsia. Finally, no specific HLA-G haplotypes were significantly associated with increased risk of developing severe preeclampsia/eclampsia.

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“…Deposits of fibrin within the placental spiral arteries and the subendothelium of kidney glomeruli are frequent pathologic changes recorded among women with pre‐eclampsia . Activation of coagulation cascades is the main factor underlying pathogenesis of pre‐eclampsia, which includes endothelial dysfunction; platelet activation and blood coagulation; deregulation of fibrinolysis; and increased activity of tissue factor . Nonetheless, traditional coagulation parameters—such as platelet count, prothrombin time, international normalized ratio, partial thromboplastin time, and D‐dimer—are insufficient to identify the alterations of the coagulation system listed above.…”

Section: Introductionmentioning

confidence: 99%

The ability of thromboelastography parameters to predict severe pre‐eclampsia when measured during early pregnancy

Wang

Cheng

et al. 2019

Intl J Gynecology & Obste

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Objective To examine the predictive value of thromboelastography parameters during early pregnancy as potential markers of severe pre‐eclampsia during late pregnancy. Methods An observational retrospective case–control study was conducted among pregnant women who attended a single hospital in Shanghai, China, between July 1, 2016, and February 31, 2018. Data were obtained from medical records and a structured questionnaire completed by the participants. Thromboelastography parameters included time r; time k; α angle; maximum amplitude; clot lysis at 60 minutes; and coagulation index. Other risk factors for severe pre‐eclampsia were also assessed. Results The pre‐eclampsia and control groups comprised 46 and 138 women, respectively. Women with a coagulation index below zero at 13–20 weeks experienced an increased risk of severe pre‐eclampsia (odds ratio [OR] 31.72, 95% confidence interval [CI] 11.28–89.24; P<0.001). Other risk factors for severe pre‐eclampsia were family history of hypertension (OR 3.79, 95% CI 1.21–11.48; P=0.017) and pre‐pregnancy body mass index (OR 2.83, 95% CI 1.14–7.36; P=0.023). Conclusion Coagulation index determined by thromboelastography was an early marker for severe pre‐eclampsia.

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Preeclampsia-An endothelial cell disorder plus “something else”?

Cited by 4 publications

References 11 publications

Interrelationship Between Markers of Oxidative Stress, Inflammation and Hematological Parameters Among Preeclamptic Nigerian Women

Interrelationship Between Markers of Oxidative Stress, Inflammation and Hematological Parameters Among Preeclamptic Nigerian Women

Distribution of HLA‐G extended haplotypes and one HLA‐E polymorphism in a large‐scale study of mother–child dyads with and without severe preeclampsia and eclampsia

The ability of thromboelastography parameters to predict severe pre‐eclampsia when measured during early pregnancy

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